Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Toshiaki Furuta"'
Autor:
Yoshimitsu Murata, Tomotaka Jitsukawa, Maiko Iida, Toshiaki Furuta, Yoshikazu Haramoto, Yasushi Shigeri, Shingo Fujisaki
Publikováno v:
Journal of Bioscience and Bioengineering. 135:382-388
Publikováno v:
Chemical Communications. 58:10484-10487
Histone deacetylases (HDACs) play crucial roles in the epigenetic regulation of gene expression. Here, we report CM-Bhc-SAHA, a novel caged HDAC inhibitor, genetically targeting cells of interest. Mammalian cells expressing porcine liver esterase led
Publikováno v:
Practica Oto-Rhino-Laryngologica. 115:587-594
Autor:
Toshiaki Furuta
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 142(5)
Photoresponsive molecules can be used to manipulate the physiological functions of cells with high spatiotemporal resolution. Caged compounds are photoresponsive molecules designed to temporarily mask their original biological activity through covale
Autor:
Akinobu Nakamura, Tatsuyuki Yoshii, Keiko Kuwata, Rei Watahiki, Shinya Tsukiji, Choji Oki, Toshiaki Furuta, Kai Tahara
Publikováno v:
ACS chemical biology. 16(8)
Manipulating subcellular protein localization using light is a powerful approach for controlling signaling processes with high spatiotemporal precision. The most widely used strategy for this is based on light-induced protein heterodimerization. The
Autor:
Hirona Sasaki, Masaki Sone, Toshiaki Furuta, Taichi Sakano, Akinobu Z. Suzuki, Kazuki Horikawa, Rei Watahiki
Publikováno v:
Chemical communications (Cambridge, England). 57(46)
We designed a new caging group that can be photoactivated only in the presence of a non-endogenous enzyme when exposed to 405 nm light. Because cells or tissues can be genetically tagged by an exogenously expressed enzyme, this novel method can serve
Autor:
Tomomi Hamaguchi, Ryosuke Aikawa, Toshiaki Furuta, Yukiko Shiraishi, Hiroyuki Okuno, Shiori Takeda, Ryota Sekine, Akinobu Z. Suzuki, Hirokazu Tamamura
Publikováno v:
Chemical Communications. 55:451-454
A 6-bromo-7-hydroxycoumarin-4-ylmethyl (Bhc) caged compound having a click-modifiable chemical handle was designed and synthesized. This molecule was applied to the synthesis of modular caged paclitaxels (PTXs) in which additional functional units co
Autor:
Takahiro Ishii, Wataru Nomura, Kohei Tsuji, Hirokazu Tamamura, Toshiaki Furuta, Hikaru Takano, Takuya Kobayakawa, Nami Ohashi
Publikováno v:
Organicbiomolecular chemistry. 18(22)
The 6-bromo-7-hydroxy-coumarin-4-ylmethyl (Bhc) group has been used widely in cage chemistry because of its high molar absorptivity and photolytic efficiency. One of the drawbacks of coumarins however is their low aqueous solubility. Aqueous solubili
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports
cAMP is one of the most important second messengers in biological processes. Cellular dynamics of cAMP have been investigated using a series of fluorescent indicators; however, their sensitivity was sub-optimal for detecting cAMP dynamics at a low co
Autor:
Yukiko Shiraishi, Toshiaki Furuta, Akinobu Z. Suzuki, Rei Watahiki, Hirona Sasaki, Hanami Aoki
Publikováno v:
Journal of Visualized Experiments.
Caged compounds enable the photo-mediated manipulation of the cell physiology with high spatiotemporal resolution. However, the limited structural diversity of currently available caging groups and the difficulties in synthetic modification without s