Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Toshiaki Aoshima"'
Autor:
Takashi Fukasawa, Toshiaki Aoshima, Hiroaki Shiraishi, Koichi Otani, Shingo Oshino, Genki Ishii, Akihito Suzuki
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 31:395-398
It has been suggested that the central serotonergic activity is implicated in personality traits. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin synthesis. In the present study, the association between the TPH A218C polymorphis
Autor:
Takaki Tokairin, Koichi Otani, Norio Yasui-Furukori, Toshiaki Aoshima, Takashi Fukasawa, Yoshimasa Inoue, Tomonori Tateishi, Akihito Suzuki
Publikováno v:
British Journal of Clinical Pharmacology. 60:172-175
Aims To obtain in vivo evidence for the involvement of cytochrome P450 (CYP) 3A4 in the metabolism of brotizolam. Methods Fourteen healthy male volunteers received erythromycin 1200 mg day−1 or placebo for 7 days in a double-blind randomized crosso
Autor:
Toshiaki Aoshima, Akihito Suzuki, Koichi Otani, Yoshimasa Inoue, Toshiki Kunii, Tomonori Tateishi, Norio Yasui-Furukori, Takashi Fukasawa
Publikováno v:
Therapeutic Drug Monitoring. 27:349-353
Authors examined a possible interaction between enoxacin, an inhibitor of cytochrome P4501A2, and fluvoxamine (FLV), a substrate for this enzyme. Ten healthy male volunteers received enoxacin 200 mg/d or placebo for 11 days in a double-blind randomiz
Autor:
Akihito Suzuki, Norio Yasui-Furukori, Toshiaki Aoshima, Takashi Fukasawa, Tomonori Tateishi, Koichi Otani
Publikováno v:
Therapeutic Drug Monitoring. 26:529-533
The effects of cytochrome P450 (CYP)2C19 activity and cigarette smoking on the single oral dose pharmacokinetics of quazepam were studied in 20 healthy Japanese volunteers. Twelve subjects were extensive metabolizers (EMs), and 8 subjects were poor m
Autor:
Norio Yasui-Furukori, Takashi Fukasawa, Akihito Suzuki, Koichi Otani, Toshiaki Aoshima, Hideto Kanda
Publikováno v:
The Journal of Clinical Pharmacology. 43:1392-1397
It has been reported that fluvoxamine, an inhibitor of various cytochrome P450 enzymes, markedly inhibits the metabolism of several drugs. The purpose of the present study was to examine a possible interaction between fluvoxamine and quazepam. Twelve
Autor:
Norio Yasui-Furukori, Toshiaki Aoshima, Takashi Fukasawa, Muneaki Kanno, Koichi Otani, Kimiyasu Kato, Akihito Suzuki
Publikováno v:
Therapeutic Drug Monitoring. 25:473-477
The effects of itraconazole, a potent inhibitor of cytochrome P450 (CYP) 3A4, on the plasma kinetics of quazepam and its two active metabolites after a single oral dose of the drug were studied. Ten healthy male volunteers received itraconazole 100 m
Autor:
Tadashi Ohkubo, Takashi Fukasawa, Ritsuko Shimoyama, Hisashi Higuchi, Toshiaki Aoshima, Tetsuo Shimizu, Yoshiko Murata, Hitoshi Takahashi, Keizo Yoshida, Koichi Otani, Gisa Gerstenberg
Publikováno v:
Therapeutic Drug Monitoring. 25:463-468
The effects of the cytochrome P450 (CYP) 2D6 genotype and cigarette smoking on the steady-state plasma concentrations (C(ss)) of fluvoxamine (FLV) and its demethylated metabolite fluvoxamino acid (FLA) were studied in 49 Japanese depressed patients r
Autor:
Masatomo Miura, Naoyuki Okuyama, Toshiaki Aoshima, Koichi Otani, Tadashi Ohkubo, Yohei Otsuji, Kazunobu Sugawara, Gisa Gerstenberg, Takashi Fukasawa
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 27:535-538
The effects of the cytochrome P450 (CYP)2C19 genotype and cigarette smoking on the single oral dose pharmacokinetics and pharmacodynamics of estazolam were studied in 16 healthy male volunteers. The two mutated alleles (CYP2C19*2 and CYP2C19*3) causi
No Effect of Itraconazole on the Single Oral Dose Pharmacokinetics and Pharmacodynamics of Estazolam
Autor:
Tadashi Ohkubo, Toshiaki Aoshima, Naoyuki Okuyama, Masatomo Miura, Kazunobu Sugawara, Kimiyasu Kato, Gisa Gerstenberg, Koichi Otani, Yohei Otsuji, Takashi Fukasawa
Publikováno v:
Therapeutic Drug Monitoring. 24:375-378
To examine the involvement of cytochrome P450 3A4 in the metabolism of estazolam, the effect of itraconazole, a potent inhibitor of this enzyme, on the single oral dose pharmacokinetics and pharmacodynamics of estazolam was studied in a double-blind
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 25:457-462
1. A 52-year-old female with refractory depression had not responded to various treatments including electroconvulsive therapy and augmentation therapy with lithium or triiodothyronine. 2. Addition of bromocriptine 2.5-5 mg/day to imipramine improved