Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Toshiaki Akira"'
Autor:
Satoshi Yuki, Toshiaki Akira, Takashi Horikawa, Hiroyuki Satoh, Yasuhiro Egi, Shigeru Matsuura
Publikováno v:
Brain Research. 1410:122-131
Overactivation of poly (ADP-ribose) polymerase-1 (PARP-1) in response to DNA damage is considered to play a crucial role in the development of post-ischemic neuronal injury, such as ischemic stroke. The present study was undertaken to clarify the ben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2516a578942fc33c4a0433fd696a28
https://doi.org/10.1016/j.brainres.2011.05.069
https://doi.org/10.1016/j.brainres.2011.05.069
Autor:
Yasuo Matsumura, Ai Yamamoto, Yasuhiro Egi, Tetsumasa Sasaoka, Masashi Tawa, Toshiaki Akira, Masanori Takaoka, Tomoyuki Maruyama, Mamoru Ohkita
Publikováno v:
Journal of Cardiovascular Pharmacology. 52:176-183
We investigated whether endogenous and exogenous angiotensin II (Ang II) regulates norepinephrine (NE) release from cardiac sympathetic nerves via both Ang II type 2 receptors (AT 2 Rs) and Ang II type 1 receptors (AT 1 Rs). Using isolated rat hearts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9e750abdb3488595b7ae23c49094f4
https://doi.org/10.1097/fjc.0b013e31818127f8
https://doi.org/10.1097/fjc.0b013e31818127f8
Autor:
Toshiaki Akira, Tom Kawamura, Takashi Imagawa, Norifumi Nakamura, Satoshi Horie, Tomoyuki Maruyama
Publikováno v:
Journal of Neurochemistry. 72:1907-1914
Neuronal apoptosis in rat pheochromocytoma PC12 cells, which was confirmed by TUNEL (terminal transferase-mediated dUTP-biotin nick end-labeling) staining and detection of chromatin condensation, appeared within 8 h after nerve growth factor (NGF) de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3826bafbdf0fb2c11b0d62bd7153f929
https://doi.org/10.1046/j.1471-4159.1999.0721907.x
https://doi.org/10.1046/j.1471-4159.1999.0721907.x
Autor:
Toshiaki Akira
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 145(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c1ba757529889f12e97338798b735f
https://pubmed.ncbi.nlm.nih.gov/25747020
https://pubmed.ncbi.nlm.nih.gov/25747020
Publikováno v:
Prostaglandins & Other Lipid Mediators. 55:95-107
The effects of prostaglandin E1 (PGE1) on adhesion of activated human polymorphonuclear cells (HPMNs) to human umbilical vein endothelial cells (HUVECs) and on chemotaxis of HPMNs were compared with those of prostaglandin I2 (PGI2) or its chemically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e31dba5bd632da073310761ffe97271
https://doi.org/10.1016/s0090-6980(98)00011-2
https://doi.org/10.1016/s0090-6980(98)00011-2
Autor:
Takeshi Yamauchi, Toru Kawamura, Tomoyuki Maruyama, Norifirmi Nakamura, Toshiaki Akira, Mamoru Koyama
Publikováno v:
Life Sciences. 61:2111-2116
RT-PCR and an in situ hybridization analyses demonstrated expression of prostaglandin EP2 receptor mRNA in the subfield of the dorsal horn of the rat spinal cord. The intensive signals from the cells labeled with digoxigenin-11-dUTP were scattered th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda75e7b67343e69f6265b05d902e76a
https://doi.org/10.1016/s0024-3205(97)00884-9
https://doi.org/10.1016/s0024-3205(97)00884-9
Publikováno v:
Neuropharmacology. 36:1023-1030
Summary Neuronal degeneration, distinguished morphologically and biochemically from necrosis, was induced in the dorsal horn of the lumbar spinal cord by chronic constriction of the sciatic nerve in rats. Neuronal apoptosis in the territory of the sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5e1dfaa0ef94c92a5479526cbd5f54
https://doi.org/10.1016/s0028-3908(97)00096-8
https://doi.org/10.1016/s0028-3908(97)00096-8
Autor:
Masakazu Fujio, Tomoyuki Maruyama, Toshiaki Akira, Yasuhiro Egi, Satoshi Yuki, Shigeru Matsuura
Publikováno v:
Brain research. 1389
Cerebral ischemia induces excessive activation of poly(ADP-ribose) polymerase-1 (PARP-1), leading to neuronal cell death and the development of post-ischemic dysfunction. Blockade of PARP-related signals during cerebral ischemia has become a focus of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083390b00bf4c40c0c7fb51b0df3280d
https://pubmed.ncbi.nlm.nih.gov/21420942
https://pubmed.ncbi.nlm.nih.gov/21420942
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 29(3)
To explore the effects of reperfusion on evolution of focal ischemic injury, spontaneously hypertensive male rats were subjected to photothrombotic distal middle cerebral artery occlusion (MCAO) with or without YAG laser-induced reperfusion. The volu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910fc74677dbc4eaa8cee3fd0edb76c5
https://pubmed.ncbi.nlm.nih.gov/19088742
https://pubmed.ncbi.nlm.nih.gov/19088742
Autor:
Kenichi Inaba, Kiyoshi Asano, Ken-ichi Katayama, Shuji Sonda, Masakazu Fujio, Toshiaki Akira, Hiroshi Sakashita
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(4)
The structure–activity relationships of novel 1,5-benzodioxepin derivatives as muscarinic M1–M3 receptor antagonists are reported. Some of these compounds were found to possess high binding affinity for the muscarinic M3 receptor and potent effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57891ebd81ed5ab9b2ea4b10a9e156f1
https://pubmed.ncbi.nlm.nih.gov/17188867
https://pubmed.ncbi.nlm.nih.gov/17188867