Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Toshiaki, Okuno"'
Autor:
Natsuki Ohkawa, Hiromichi Shoji, Naho Ikeda, Yayoi Murano, Toshiaki Okuno, Masato Kantake, Takehiko Yokomizo, Toshiaki Shimizu
Publikováno v:
Pediatrics and Neonatology, Vol 65, Iss 2, Pp 123-126 (2024)
Background: There is limited evidence on the association between the clinical course of patent ductus arteriosus (PDA) and prostaglandin (PG) metabolites. This study aimed to determine the influence of PDA treatment on urinary PG metabolite excretion
Externí odkaz:
https://doaj.org/article/146b288bbee440dcb3d3e1d7a7629b1a
Autor:
Airi Jo-Watanabe, Toshiki Inaba, Takahiro Osada, Ryota Hashimoto, Tomohiro Nishizawa, Toshiaki Okuno, Sayoko Ihara, Kazushige Touhara, Nobutaka Hattori, Masatsugu Oh-Hora, Osamu Nureki, Takehiko Yokomizo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Homoeostatic regulation of the acid–base balance is essential for cellular functional integrity. However, little is known about the molecular mechanism through which the acid–base balance regulates cellular responses. Here, we report tha
Externí odkaz:
https://doaj.org/article/f95ce9a7d6854817a73fa616defc04d5
Autor:
Sophia Koutsogiannaki, Lifei Hou, Toshiaki Okuno, Miho Shibamura-Fujiogi, Hongbo R. Luo, Koichi Yuki
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Since sepsis was defined three decades ago, it has been a target of intensive study. However, there is no specific sepsis treatment available, with its high mortality and morbidity. αDβ2 (CD11d/CD18) is one of the four β2 integrin members. Its rol
Externí odkaz:
https://doaj.org/article/057085c054644192ab8c27b70b2e3570
Autor:
Fumie Nakashima, Takashi Suzuki, Odaine N. Gordon, Dominic Golding, Toshiaki Okuno, Juan A. Giménez-Bastida, Takehiko Yokomizo, Claus Schneider
Publikováno v:
JACS Au, Vol 1, Iss 9, Pp 1380-1388 (2021)
Externí odkaz:
https://doaj.org/article/767303db875b4c539101de30ffc05318
Autor:
Keisuke Jimbo, Toshiaki Okuno, Ryuichi Ohgaki, Kou Nishikubo, Yuri Kitamura, Yumiko Sakurai, Lili Quan, Hiromichi Shoji, Yoshikatsu Kanai, Toshiaki Shimizu, Takehiko Yokomizo
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247691 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0241869.].
Externí odkaz:
https://doaj.org/article/7ecbdf20d5d34a97a5b6a615b1007e59
Autor:
Nanase Takahashi, Toshiaki Okuno, Hiroki Fujii, Shintaro Makino, Masaya Takahashi, Mai Ohba, Kazuko Saeki, Atsuo Itakura, Satoru Takeda, Takehiko Yokomizo
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250638 (2021)
Prostaglandin E2 (PGE2) is known to have important roles in labor, but the detailed mechanism underlying the spontaneous human labor remains unknown. Here, we examined the involvement of prostaglandin biosynthetic enzymes and transporter in the accum
Externí odkaz:
https://doaj.org/article/ecaba9889a3043abbac8a23796437d5d
Autor:
Keisuke Jimbo, Toshiaki Okuno, Ryuichi Ohgaki, Kou Nishikubo, Yuri Kitamura, Yumiko Sakurai, Lili Quan, Hiromichi Shoji, Yoshikatsu Kanai, Toshiaki Shimizu, Takehiko Yokomizo
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241869 (2020)
Chronic enteropathy associated with SLCO2A1 gene (CEAS) is caused by loss-of-function mutations in SLCO2A1, which encodes a prostaglandin (PG) transporter. In this study, we report a sibling case of CEAS with a novel pathogenic variant of the SLCO2A1
Externí odkaz:
https://doaj.org/article/33c367819fab4eb68e2c495376f902ea
Biological functions of 12(S)-hydroxyheptadecatrienoic acid as a ligand of leukotriene B4 receptor 2
Autor:
Toshiaki Okuno, Takehiko Yokomizo
Publikováno v:
Inflammation and Regeneration, Vol 38, Iss 1, Pp 1-5 (2018)
Abstract Although 12(S)-hydroxyheptadecatrienoic acid (12-HHT) is an abundant fatty acid, it is long considered a byproduct of thromboxane A2 production. We identified a leukotriene B4 receptor 2 (BLT2)-specific agonistic activity in lipid extracts f
Externí odkaz:
https://doaj.org/article/62a16a87dc6846708e3935250bb7e215
Autor:
Toshiaki Okuno, Miguel A. Gijón, Simona Zarini, Sarah A. Martin, Robert M. Barkley, Christopher A. Johnson, Mai Ohba, Takehiko Yokomizo, Robert C. Murphy
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 3, Pp 542-549 (2018)
The remodeling of PUFAs by the Lands cycle is responsible for the diversity of phospholipid molecular species found in cells. There have not been detailed studies of the alteration of phospholipid molecular species as a result of serum starvation or
Externí odkaz:
https://doaj.org/article/f75350d1634a4f01a6b888f4437716dc
Publikováno v:
The Journal of Biochemistry. 173:293-305
12(S)-hydroxyheptadecatrienoic acid (12-HHT) is a bioactive fatty acid synthesized from arachidonic acid via the cyclooxygenase pathway and serves as an endogenous ligand for the low-affinity leukotriene B4 receptor 2 (BLT2). Although the 12-HHT/BLT2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f7da82e1170d01af483654cc6408a8
https://doi.org/10.1093/jb/mvac105
https://doi.org/10.1093/jb/mvac105