Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Toshiaki, Akahane"'
Autor:
Kenji Miki, Mikako Yagi, Ryusuke Hatae, Ryosuke Otsuji, Takahiro Miyazaki, Katsuhiro Goto, Daiki Setoyama, Yutaka Fujioka, Yuhei Sangatsuda, Daisuke Kuga, Nayuta Higa, Tomoko Takajo, Yonezawa Hajime, Toshiaki Akahane, Akihide Tanimoto, Ryosuke Hanaya, Yuya Kunisaki, Takeshi Uchiumi, Koji Yoshimoto
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Background Glioblastoma is an aggressive cancer that originates from abnormal cell growth in the brain and requires metabolic reprogramming to support tumor growth. Metabolic reprogramming involves the upregulation of various metabolic pathw
Externí odkaz:
https://doaj.org/article/23f043fda09d44aaa5d57d362572bfb0
Autor:
Mari Kirishima, Seiya Yokoyama, Toshiaki Akahane, Nayuta Higa, Hiroyuki Uchida, Hajime Yonezawa, Kei Matsuo, Junkoh Yamamoto, Koji Yoshimoto, Ryosuke Hanaya, Akihide Tanimoto
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Glioblastomas (GBMs) are the most aggressive types of central nervous system tumors. Although certain genomic alterations have been identified as prognostic biomarkers of GBMs, the histomorphological features that predict their prognosis rem
Externí odkaz:
https://doaj.org/article/ca1a6b39034b432fb711dd4038deb0be
Autor:
Taiji Hamada, Michiyo Higashi, Seiya Yokoyama, Toshiaki Akahane, Masanori Hisaoka, Hirotsugu Noguchi, Tatsuhiko Furukawa, Akihide Tanimoto
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a cancer biomarker. Furthermore, fusion of the MALAT1 gene with glioma-associated oncogene 1 (GLI1) is a diagnostic marker of plexiform fib
Externí odkaz:
https://doaj.org/article/d8a8e7c3664644eaa42651a87674c594
Autor:
Nayuta Higa, Toshiaki Akahane, Taiji Hamada, Hajime Yonezawa, Hiroyuki Uchida, Ryutaro Makino, Shoji Watanabe, Tomoko Takajo, Seiya Yokoyama, Mari Kirishima, Kei Matsuo, Shingo Fujio, Ryosuke Hanaya, Akihide Tanimoto, Koji Yoshimoto
Publikováno v:
Cancer Medicine, Vol 12, Iss 1, Pp 49-60 (2023)
Abstract Background We aimed to evaluate the mutation profile, transcriptional variants, and prognostic impact of the epidermal growth factor receptor (EGFR) gene in isocitrate dehydrogenase (IDH)‐wildtype glioblastomas (GBMs). Methods We sequenced
Externí odkaz:
https://doaj.org/article/4c6bd20f275d4736930ec1130baa61f2
Autor:
Nayuta HIGA, Toshiaki AKAHANE, Seiya YOKOYAMA, Hajime YONEZAWA, Hiroyuki UCHIDA, Shingo FUJIO, Mari KIRISHIMA, Kosuke TAKIGAWA, Nobuhiro HATA, Keita TOH, Junkoh YAMAMOTO, Ryosuke HANAYA, Akihide TANIMOTO, Koji YOSHIMOTO
Publikováno v:
Neurologia Medico-Chirurgica, Vol 62, Iss 9, Pp 391-399 (2022)
Rapid technological advances in molecular biology, including next-generation sequencing, have identified key genetic alterations in central nervous system (CNS) tumors. Accordingly, the fifth edition of the World Health Organization (WHO) CNS tumor c
Externí odkaz:
https://doaj.org/article/71f1b1a333e64450a6db85d29bf4ba3a
Autor:
Mari Kirishima, Seiya Yokoyama, Kei Matsuo, Taiji Hamada, Michiko Shimokawa, Toshiaki Akahane, Tomoyuki Sugimoto, Hirohito Tsurumaru, Matsujiro Ishibashi, Yuko Mataki, Takao Ootsuka, Mitsuharu Nomoto, Chihiro Hayashi, Akihiko Horiguchi, Michiyo Higashi, Akihide Tanimoto
Publikováno v:
BMC Microbiology, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background The microbial population of the intestinal tract and its relationship to specific diseases has been extensively studied during the past decade. However, reports characterizing the bile microbiota are rare. This study aims to inves
Externí odkaz:
https://doaj.org/article/3635136ddd324a79ae425cae022b3c01
Autor:
Taiji Hamada, Toshiaki Akahane, Seiya Yokoyama, Nayuta Higa, Mari Kirishima, Kei Matsuo, Michiko Shimokawa, Koji Yoshimoto, Akihide Tanimoto
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Understanding human genome alterations is necessary to optimize genome-based cancer therapeutics. However, some newly discovered mutations remain as variants of unknown significance (VUS). Here, the mutation c.1403A > G in exon 10 of the pla
Externí odkaz:
https://doaj.org/article/6674d42c09f94f549df969b2710ed483
Autor:
Hiromichi Iwaya, Akihide Tanimoto, Koshiro Toyodome, Issei Kojima, Makoto Hinokuchi, Shiroh Tanoue, Shinichi Hashimoto, Machiko Kawahira, Shiho Arima, Shuji Kanmura, Toshiaki Akahane, Michiyo Higashi, Shinsuke Suzuki, Shinichi Ueno, Takao Ohtsuka, Akio Ido
Publikováno v:
Diagnostics, Vol 13, Iss 6, p 1078 (2023)
This study evaluated the feasibility and clinical utility of liquid-based cytology (LBC) specimens via endoscopic ultrasound–guided fine-needle biopsy (EUS-FNB) for next-generation sequencing (NGS) of pancreatic cancer (PC). We prospectively evalua
Externí odkaz:
https://doaj.org/article/0e49e606bc9b40c09c1dd78967790b47
Autor:
Toshiaki Akahane, Naoki Kanomata, Oi Harada, Tetsumasa Yamashita, Junichi Kurebayashi, Akihide Tanimoto, Takuya Moriya
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Next-generation sequencing (NGS) has shown that recurrent/metastatic breast cancer lesions may have additional genetic changes compared with the primary tumor. These additional changes may be related to tumor progression and/or dr
Externí odkaz:
https://doaj.org/article/4a94328c201145c397ad92c2dc7126b0
Autor:
Yoshiaki Shinden, Hazuki Saho, Yuki Nomoto, Ayako Nagata, Koji Minami, Akihiro Nakajo, Toshiaki Akahane, Tsubasa Hiraki, Akihide Tanimoto, Tetsuhiro Owaki, Yuko Kijima, Shoji Natsugoe
Publikováno v:
Surgical Case Reports, Vol 6, Iss 1, Pp 1-6 (2020)
Abstract Background When diagnosing patients with bilateral breast cancer, it is challenging to determine the relationship between multiple breast cancer lesions at the individual patient level with certainty. Case presentation A 35-year-old Japanese
Externí odkaz:
https://doaj.org/article/c82ea60e049f488e90a222cb502ed28e