Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Toshal R. Patel"'
Autor:
Louise Dickson, Martin Teall, Elodie Chevalier, Toni Cheung, Gemma M. Liwicki, Stephen Mack, Anne Stephenson, Kathryn White, Richard Fosbeary, David C. Harrison, Nicola L. Brice, Kevin Doyle, Roberto Ciccocioppo, Chaobo Wu, Sarah Almond, Toshal R. Patel, Philip Mitchell, Matt Barnes, Andrew P. Ayscough, Lee A. Dawson, Mark Carlton, Roland W. Bürli
Publikováno v:
ACS Medicinal Chemistry Letters. 14:442-449
Amphiphysin I phosphorylation on residue threonine 260 in a pentylenetetrazole-induced seizure model
Autor:
Toshal R. Patel, Mowdood Choudhury, James M. Staddon, Oliver Kleiner, Raymond T. Chung, Louise Morgan, Laura Barden
Publikováno v:
Neuroscience Letters. 444:245-249
A method to evaluate kinase inhibitor action was reported [L. Morgan, S.J. Neame, H. Child, R. Chung, B. Shah, L. Barden, J.M. Staddon, T.R. Patel, Development of a pentylenetetrazole-induced seizure model to evaluate kinase inhibitor efficacy in the
Autor:
Bina Shah, Laura Barden, Louise Morgan, Toshal R. Patel, Stephen J. Neame, James M. Staddon, Raymond T. Chung, Hannah Child
Publikováno v:
Neuroscience Letters. 395:143-148
c-Jun N-terminal kinases (JNKs) are implicated in cell death in neurodegenerative disorders. Therefore, JNK inhibitors could act as neuroprotective agents. To evaluate potential candidates, reproducible and quantitative CNS in vivo models are require
Autor:
Adrian, Hall, Toshal R, Patel
Publikováno v:
Progress in medicinal chemistry. 53
This chapter reviews the current status of γ-secretase modulators, highlighting key compounds by each company involved in the area. The review focuses on the three main chemotypes: acids, imidazoles and related derivatives and natural products. A se
Autor:
Hussein Hallak, James McCulloch, Samuel Galbraith, David I. Graham, Annette Marian Doherty, Toshal R. Patel
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 16:950-958
These investigations characterised the cerebrovascular effects of an endothelin ETA-receptor antagonist PD156707 in normal and ischaemic cat brain. A dose of PD156707 that inhibited the effects of exogenous endothelin-1 was established in nonischaemi
Publikováno v:
European Journal of Pharmacology. 307:41-48
The receptors mediating the cerebrovascular actions of endothelins have been examined in feline cerebral resistance arterioles in vivo. The adventitial microapplication of the endothelin ETA receptor antagonist BQ-123 (cyclo D-aspartate-D-tryptophan-
Autor:
Toshal R. Patel
Publikováno v:
CNS Drugs. 5:293-310
Summary The actions of the endothelins (endothelin-I. endothelin-2 and endothelin-3) are mediated via endothelin-A (EA) and endothelin-B (ETB) receptors. the former generally mediating vasoconstriction and the latter vasodilation. Peptide antagonists
Publikováno v:
Brain Research. 712:329-334
The effect of the kappa-opioid agonist enadoline (CI-977) upon the relationship between cerebral blood flow and glutamate release was simultaneously assessed (using microdialysis and hydrogen clearance techniques respectively) at the same anatomical
AMPA receptor antagonism attenuates MK-801-induced hypermetabolism in the posterior cingulate cortex
Autor:
Toshal R. Patel, James McCulloch
Publikováno v:
Brain Research. 686:254-258
The effect of pretreatment with an AMPA receptor antagonist, NBQX, on MK-801-induced alterations in glucose use was examined using [14C]-2-deoxyglucose autoradiography. NBQX (7 mg/kg) had minimal effect on glucose utilisation in all anatomical region
Autor:
James McCulloch, Toshal R. Patel
Publikováno v:
Journal of Cardiovascular Pharmacology. 26:S425-428
The role of endogenous endothelins (ETs) in mediating postischemic hypoperfusion after transient global ischemia was investigated in halothane-anesthetized rats. Pretreatment with the broad spectrum ET A and ET B antagonist bosentan (17 μmol/kg) had