Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Toshal R. Patel"'
Amphiphysin I phosphorylation on residue threonine 260 in a pentylenetetrazole-induced seizure model
Autor:
Toshal R. Patel, Mowdood Choudhury, James M. Staddon, Oliver Kleiner, Raymond T. Chung, Louise Morgan, Laura Barden
Publikováno v:
Neuroscience Letters. 444:245-249
A method to evaluate kinase inhibitor action was reported [L. Morgan, S.J. Neame, H. Child, R. Chung, B. Shah, L. Barden, J.M. Staddon, T.R. Patel, Development of a pentylenetetrazole-induced seizure model to evaluate kinase inhibitor efficacy in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67faf365c3c2c2053413f55ff6240e8
https://doi.org/10.1016/j.neulet.2008.08.055
https://doi.org/10.1016/j.neulet.2008.08.055
Autor:
Bina Shah, Laura Barden, Louise Morgan, Toshal R. Patel, Stephen J. Neame, James M. Staddon, Raymond T. Chung, Hannah Child
Publikováno v:
Neuroscience Letters. 395:143-148
c-Jun N-terminal kinases (JNKs) are implicated in cell death in neurodegenerative disorders. Therefore, JNK inhibitors could act as neuroprotective agents. To evaluate potential candidates, reproducible and quantitative CNS in vivo models are require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8f08aafb8cb69e4d92d9a2aa6cd6f0
https://doi.org/10.1016/j.neulet.2005.10.068
https://doi.org/10.1016/j.neulet.2005.10.068
Autor:
Hussein Hallak, James McCulloch, Samuel Galbraith, David I. Graham, Annette Marian Doherty, Toshal R. Patel
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 16:950-958
These investigations characterised the cerebrovascular effects of an endothelin ETA-receptor antagonist PD156707 in normal and ischaemic cat brain. A dose of PD156707 that inhibited the effects of exogenous endothelin-1 was established in nonischaemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374894da6ff6e02d8e73e286f8d898e6
https://doi.org/10.1097/00004647-199609000-00019
https://doi.org/10.1097/00004647-199609000-00019
Publikováno v:
European Journal of Pharmacology. 307:41-48
The receptors mediating the cerebrovascular actions of endothelins have been examined in feline cerebral resistance arterioles in vivo. The adventitial microapplication of the endothelin ETA receptor antagonist BQ-123 (cyclo D-aspartate-D-tryptophan-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254bb861d992e869a7fe289f750745e7
https://doi.org/10.1016/0014-2999(96)00188-4
https://doi.org/10.1016/0014-2999(96)00188-4
Autor:
Toshal R. Patel
Publikováno v:
CNS Drugs. 5:293-310
Summary The actions of the endothelins (endothelin-I. endothelin-2 and endothelin-3) are mediated via endothelin-A (EA) and endothelin-B (ETB) receptors. the former generally mediating vasoconstriction and the latter vasodilation. Peptide antagonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::258062be25aa2a9cbabb3bdc0cd1df97
https://doi.org/10.2165/00023210-199605040-00007
https://doi.org/10.2165/00023210-199605040-00007
Publikováno v:
Brain Research. 712:329-334
The effect of the kappa-opioid agonist enadoline (CI-977) upon the relationship between cerebral blood flow and glutamate release was simultaneously assessed (using microdialysis and hydrogen clearance techniques respectively) at the same anatomical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbdb40efdbd6f365df4a0b4aa64da92
https://doi.org/10.1016/0006-8993(95)01559-0
https://doi.org/10.1016/0006-8993(95)01559-0
AMPA receptor antagonism attenuates MK-801-induced hypermetabolism in the posterior cingulate cortex
Autor:
Toshal R. Patel, James McCulloch
Publikováno v:
Brain Research. 686:254-258
The effect of pretreatment with an AMPA receptor antagonist, NBQX, on MK-801-induced alterations in glucose use was examined using [14C]-2-deoxyglucose autoradiography. NBQX (7 mg/kg) had minimal effect on glucose utilisation in all anatomical region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44220fc81c12ae93c758912a139d6e9
https://doi.org/10.1016/0006-8993(95)00483-7
https://doi.org/10.1016/0006-8993(95)00483-7
Autor:
James McCulloch, Toshal R. Patel
Publikováno v:
Journal of Cardiovascular Pharmacology. 26:S425-428
The role of endogenous endothelins (ETs) in mediating postischemic hypoperfusion after transient global ischemia was investigated in halothane-anesthetized rats. Pretreatment with the broad spectrum ET A and ET B antagonist bosentan (17 μmol/kg) had
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::069027decf4a7ef09e8a81c6fc99e091
https://doi.org/10.1097/00005344-199506263-00125
https://doi.org/10.1097/00005344-199506263-00125
Publikováno v:
European Journal of Pharmacology. 260:65-71
The cerebrovascular actions of bosentan, a novel endothelin antagonist with effects at endothelin ETA and ETB receptors, have been examined in individual pial arterioles on the cortical surface of chloralose-anaesthetised cats. Subarachnoid perivascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd21261e5ed2f937bd19c4a60aa47b9e
https://doi.org/10.1016/0014-2999(94)90010-8
https://doi.org/10.1016/0014-2999(94)90010-8
Publikováno v:
Brain research. 829(1-2)
Subdural hematomas (SDH) can induce ischemia and neuronal damage in the underlying cortex. However, the extent to which intracerebral hematomas (ICH) produce reductions in cerebral blood flow (CBF) sufficient to cause ischemic damage is uncertain. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f727553fef86a63b23329c6868374d6
https://pubmed.ncbi.nlm.nih.gov/10350538
https://pubmed.ncbi.nlm.nih.gov/10350538