Simulation optimisation to inform economic evaluations of sequential therapies for chronic conditions : a case study in Rheumatoid Arthritis

Autor: Tosh, Jonathan

This thesis investigates the problem of treatment sequencing within health economic evaluations. For some chronic conditions, sequences of treatments can be used. When there are a lot of alternative treatments, then the number of possible sequences b

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675043

Health Assessment Questionnaire disability progression in early rheumatoid arthritis: Systematic review and analysis of two inception cohorts

Autor: Norton, Sam, Fu, Bo, Scott, David L., Deighton, Chris, Symmons, Deborah P.M., Wailoo, Allan J., Tosh, Jonathan, Lunt, Mark, Davies, Rebecca, Young, Adam, Verstappen, Suzanne M.M

Publikováno v: In Seminars in Arthritis and Rheumatism October 2014 44(2):131-144

Guidelines: Management of Rheumatoid Arthritis: Summary of NICE Guidance

Autor: Deighton, Chris, O'Mahony, Rachel, Tosh, Jonathan, Turner, Claire, Rudolf, Michael

Publikováno v: BMJ: British Medical Journal, 2009 Mar . 338(7696), 710-712.

Externí odkaz: https://www.jstor.org/stable/20512425

A Framework for the Economic Evaluation of Sequential Therapies for Chronic Conditions (2014)

Autor: Tosh, Jonathan, Stevenson, Matthew, Akehurst, Ronald, Strong, Mark

Background:Cost-effectiveness models often evaluate a sequence of treatments Downstream implications of a sequence should be captured Compare sequences within standard economic evaluation framework Problem: For conditions such as rheumatoid arthritis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f9f80ab1a935fa7fcf25c0c2418929

Does intensive management improve remission rates in patients with intermediate rheumatoid arthritis? (the TITRATE trial):Study protocol for a randomised controlled trial

Autor: Martin, Naomi H., Ibrahim, Fowzia, Tom, Brian, Galloway, James, Wailoo, Allan, Tosh, Jonathan, Lempp, Heidi, Prothero, Louise, Georgopoulou, Sofia, Sturt, Jackie, Scott, David L., Jenner, Richard, Neatrour, Isabel, Baggott, Rhiannon, Kingsley, Gabrielle, Zhong, Yujie, Mian, Aneela

Publikováno v: Martin, N H, Ibrahim, F, Tom, B, Galloway, J, Wailoo, A, Tosh, J, Lempp, H, Prothero, L, Georgopoulou, S, Sturt, J, Scott, D L, Jenner, R, Neatrour, I, Baggott, R, Kingsley, G, Zhong, Y & Mian, A 2017, ' Does intensive management improve remission rates in patients with intermediate rheumatoid arthritis? (the TITRATE trial) : Study protocol for a randomised controlled trial ', Trials, vol. 18, no. 1, 591 . https://doi.org/10.1186/s13063-017-2330-8

Background: Uncontrolled active rheumatoid arthritis can lead to increasing disability and reduced quality of life over time. 'Treating to target' has been shown to be effective in active established disease and also in early disease. However, there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2761::beb14aa0f37adf2b075171a743d64781
https://kclpure.kcl.ac.uk/ws/files/83574361/Does_intensive_management_improve_MARTIN_Publishedonline8December2017_GOLD_VoR_CC_BY_.pdf