CREB signaling activity correlates with differentiation and survival in medulloblastoma

Autor: Walderik W. Zomerman, Sophia W.M. Bruggeman, Eduardo Sabino de Camargo Magalhães, Harm Jan Lourens, Frank J. G. Scherpen, Eveline S. J. M. de Bont, Tosca. E. I. Martini, Marlinde J. Smit, Shanna M. Hogeling, Tiny G. J. Meeuwsen-de Boer, Sabine L. A. Plasschaert, Geesina C. Rozema-Huizinga, Inna Armandari

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports, 11(1):16077. Nature Publishing Group

While there has been significant progress in the molecular characterization of the childhood brain cancer medulloblastoma, the tumor proteome remains less explored. However, it is important to obtain a complete understanding of medulloblastoma protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd34b901125eb57feb5a6b2d298848a
https://doaj.org/article/4b52aa87cc92410bae837f1ba12b32f3

The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma

Autor: Jonas Seiler, Marin T Mondria, Irena Bockaj, Marcel A. T. M. van Vugt, Bjorn Bakker, Diana C.J. Spierings, Femke Ringnalda, Saskia L Meuleman, Mathilde J.C. Broekhuis, Ulrich Schüller, Floris Foijer, Hans Clevers, Colin Stok, Tosca. E. I. Martini, Eduardo Sabino de Camargo Magalhães, Hilda van den Bos, Yannick P Kok, Tiny G. J. Meeuwsen-de Boer, Inna Armandari, René Wardenaar, Petra L. Bakker, Sophia W.M. Bruggeman

Publikováno v: PLoS Genetics, Vol 17, Iss 11 (2021)
PLoS Genetics, 17(11). Public Library of Science
PLoS genetics, 17(11):1009868. PUBLIC LIBRARY SCIENCE
PLoS Genetics, Vol 17, Iss 11, p e1009868 (2021)
Bočkaj, I, Martini, T E I, de Camargo Magalhães, E S, Bakker, P L, Meeuwsen-de Boer, T G J, Armandari, I, Meuleman, S L, Mondria, M T, Stok, C, Kok, Y P, Bakker, B, Wardenaar, R, Seiler, J, Broekhuis, M J C, van den Bos, H, Spierings, D C J, Ringnalda, F C A, Clevers, H, Schüller, U, van Vugt, M A T M, Foijer, F & Bruggeman, S W M 2021, ' The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma ', PLoS Genetics, vol. 17, no. 11, e1009868, pp. e1009868 . https://doi.org/10.1371/journal.pgen.1009868
PLoS Genetics, 17(11):e1009868. Public Library of Science
PLoS Genetics

While comprehensive molecular profiling of histone H3.3 mutant pediatric high-grade glioma has revealed extensive dysregulation of the chromatin landscape, the exact mechanisms driving tumor formation remain poorly understood. Since H3.3 mutant gliom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d157360aabb1f0585911942661e0904
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604337/?tool=EBI

MEDU-07. THE DEVELOPMENTAL STAGE OF THE MEDULLOBLASTOMA CELL-OF-ORIGIN IS MAINTAINED IN CANCER AND RESTRICTS HEDGEHOG PATHWAY USAGE AND DRUG SENSITIVITY

Autor: Wilfred F. A. den Dunnen, Irena Bockaj, Judith T.M.L. Paridaen, Victor Guryev, Eelco W. Hoving, Gerald de Haan, Zillah Siragna, Mirthe H. Schoots, Tosca. E. I. Martini, Tiny G. J. Meeuwsen-de Boer, Frank J. G. Scherpen, Marlinde J. Smit, Martha Ritsema, Sophia W.M. Bruggeman, Inna Armandari, Walderik W. Zomerman

Publikováno v: Neuro-Oncology. 21:ii104-ii104

Sonic Hedgehog (SHH) medulloblastoma originates from the cerebellar granule neuron progenitor (CGNP) population that depends on Hedgehog signaling for its expansion. While SHH tumors are characterized by an overall deregulation of this pathway, they

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710172dc6d539dee463bd2156d8db0d7
https://doi.org/10.1093/neuonc/noz036.167