Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tory Prestera"'
Publikováno v:
Analytical Biochemistry. 239:160-167
A recently developed UV spectroscopic method for quantitating isothiocyanates (R-N=C=S) at the nanomole level is based on the observation that the highly electrophilic central carbon atom of the -N=C=S group can undergo successive nucleophilic additi
Autor:
Chitrananda Abeygunawardana, Tory Prestera, Joseph L. Kachinski, W. David Holtzclaw, Paul Talalay, Jed W. Fahey
Publikováno v:
Analytical Biochemistry. 239:168-179
Much effort has been devoted to developing methods for the efficient isolation and identification of glucosinolates. Existing methods for separation involve ion exchange, GLC, and HPLC (mostly after chemical modification by enzymatic sulfate removal
Publikováno v:
Molecular Medicine. 1:827-837
Heme oxygenase (HO; EC 1.14.99.3) catalyzes the conversion of heme to biliverdin, which is reduced enzymatically to bilirubin. Since bilirubin is a potent antioxidant and heme a pro-oxidant, HO may protect cells against oxidative damage. HO-1 is high
Autor:
W. David Holtzclaw, Tory Prestera, Ryan R. Putzer, Kristina L. Wade, Yuesheng Zhang, Paul Talalay
Publikováno v:
Chemical Research in Toxicology. 8:103-110
The induction of NAD(P)H:quinone reductase (EC 1.6.99.2; QR) in Hepa 1c1c7 murine hepatoma cells provides a versatile quantitative model for measuring the potencies of inducers for Phase 2 detoxication enzymes. Since many inducers of these enzymes al
Autor:
Tory Prestera, Thomas J. Curphey, Adam H. Libby, Patricia A. Egner, Thomas W. Kensler, H. Howard Joyner, Paul Talalay
Publikováno v:
Carcinogenesis. 15:177-181
4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione (oltipraz) and several other dithiolethiones protect against the acute toxicities of many xenobiotics and are effective inhibitors of experimental carcinogenesis. These protective effects are mediated, in
Publikováno v:
Biochemistry. 31:824-833
Cibacron Blue, a widely used ligand for affinity chromatography, is a potent inhibitor of NAD(P)H:(quinone-acceptor) oxidoreductase (EC 1.6.99.2) (quinone reductase). This property has been exploited to purify quinone reductase, to identify its nucle
Publikováno v:
Toxicology letters.
Mammalian cells have evolved elaborate mechanisms for protection against the toxic and neoplastic effects of electrophilic metabolites of carcinogens and reactive oxygen species. Phase 2 enzymes (e.g. glutathione transferase, NAD(P)H:quinone reductas
Autor:
Tory Prestera, Paul Talalay
Detoxication (phase 2) enzymes, such as glutathione S-transferases (GSTs), NAD(P)H:(quinone-acceptor) oxidoreductase (QR), and UDP-glucuronsyltransferase, are induced in animal cells exposed to a variety of electrophilic compounds and phenolic antiox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b7c0d507021b84b3badacb5f4d7b40
https://europepmc.org/articles/PMC41088/
https://europepmc.org/articles/PMC41088/
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 90(7)
Inductions of detoxication (phase 2) enzymes, such as glutathione transferases and NAD(P)H:(quinone-acceptor) oxidoreductase, are a major mechanism for protecting animals and their cells against the toxic and neoplastic effects of carcinogens. These
Publikováno v:
Advances in enzyme regulation. 33
Exposure of rodents or their cells in culture to low doses of a wide variety of chemical agents, many of which are electrophiles, evokes a coordinated metabolic response that protects these systems against the toxicity (including mutagenicity and car