Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS

Autor: Coyne, Alyssa N., Lorenzini, Ileana, Chou, Ching-Chieh, Torvund, Meaghan, Rogers, Robert S., Starr, Alexander, Zaepfel, Benjamin L., Levy, Jennifer, Johannesmeyer, Jeffrey, Schwartz, Jacob C., Nishimune, Hiroshi, Zinsmaier, Konrad, Rossoll, Wilfried, Sattler, Rita, Zarnescu, Daniela C.

Amyotrophic lateral sclerosis (ALS) is a synaptopathy accompanied by the presence of cytoplasmic aggregates containing TDP-43, an RNA-binding protein linked to similar to 97% of ALS cases. Using a Drosophila model of ALS, we show that TDP-43 overexpr

Externí odkaz: http://hdl.handle.net/10150/625980
http://arizona.openrepository.com/arizona/handle/10150/625980

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Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS.

Autor: Coyne AN; Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA; Department of Neuroscience, University of Arizona, Tucson, AZ 85721, USA., Lorenzini I; Department of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA., Chou CC; Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA., Torvund M; Department of Neuroscience, University of Arizona, Tucson, AZ 85721, USA., Rogers RS; Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA., Starr A; Department of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA., Zaepfel BL; Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA., Levy J; Department of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA., Johannesmeyer J; Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA., Schwartz JC; Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA., Nishimune H; Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA., Zinsmaier K; Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA; Department of Neuroscience, University of Arizona, Tucson, AZ 85721, USA., Rossoll W; Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA., Sattler R; Department of Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA., Zarnescu DC; Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA; Department of Neuroscience, University of Arizona, Tucson, AZ 85721, USA; Department of Neurology, University of Arizona, Tucson, AZ 85721, USA. Electronic address: zarnescu@email.arizona.edu.

Publikováno v: Cell reports [Cell Rep] 2017 Oct 03; Vol. 21 (1), pp. 110-125.