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No adverse events were observed in clozapine‐treated patients on extended hematologic monitoring intervals during the coronavirus pandemic in four psychiatric centers in Japan

Publikováno v: Neuropsychopharmacology Reports, Vol 41, Iss 2, Pp 179-184 (2021)

Abstract Aim As an emergency measure during the coronavirus disease pandemic, the monitoring interval for clozapine use was temporarily extended beyond the regulatory requirement in Japan, which is the safest monitoring interval worldwide. In this st

Externí odkaz: https://doaj.org/article/a3d80688dc394a1c92b080007086c1d9

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Association of FKBP5 gene haplotypes with completed suicide in the Japanese population

Autor: Akitoyo Hishimoto, Irwan Supriyanto, Yasuhiro Ueno, Yasushi Nagasaki, Osamu Shirakawa, Toru Sasada, Masaaki Fukutake, Migiwa Asano

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 35:252-256

The hypothalamus-pituitary-adrenal (HPA) axis is known to have a role in suicidal behaviors in patients with affective disorders. However, the incomplete overlapping of the genetic factors of suicidal behaviors and the genetic factors of affective di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c547853d305a183cf93c4e34a68ccc9
https://doi.org/10.1016/j.pnpbp.2010.11.019

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Methoxy- and Fluorine-Substituted Analogs of O-1302: Synthesis and in Vitro Binding Affinity for the CB1 Cannabinoid Receptor

Autor: Kiichi Ishiwata, Minoru Maeda, Shintaro Tobiishi, Yumiko Nojiri, Toru Sasada, Fumihiko Yamamoto, Takahiro Mukai

Publikováno v: Chemical and Pharmaceutical Bulletin. 55:1213-1217

Methoxy and fluorine analogs substituted on the terminal carbon of the pentyl chain of N-(piperidinyl)-1-(2,4-dichlorophenyl)-4-methyl-5-(4-pentylphenyl)-1H-pyrazole-3-carboxamide (O-1302) were synthesized in a multi-step process from 5-phenyl-1-pent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d509d93e00e04b535c3887fff9ddc1
https://doi.org/10.1248/cpb.55.1213

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Haplotype analysis of the DISC1 Ser704Cys variant in Japanese suicide completers

Autor: Migiwa Asano, Kentaro Mouri, Akitoyo Hishimoto, Irwan Supriyanto, Osamu Shirakawa, Yasuhiro Ueno, Ichiro Sora, Kyoichi Shiroiwa, Woraphat Ratta-apha, Satoshi Okazaki, Toru Sasada, Masakuni Yoshida

Publikováno v: Psychiatry research. 215(1)

The present study investigated the genetic association of the disrupted-in-schizophrenia 1 (DISC1) gene with suicide using 398 Japanese completed suicides and 511 healthy controls. The functional Ser704Cys variant of DISC1 was nominally associated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::221fda8e6d51ba80515f287081fe4189
https://pubmed.ncbi.nlm.nih.gov/24289909

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Association analysis of putative cis-acting polymorphisms of interleukin-19 gene with schizophrenia

Autor: Toshiyuki Someya, Ayako Nunokawa, Akitoyo Hishimoto, Woraphat Ratta-apha, Kentaro Mouri, Toru Sasada, Masako Shibuya, Naoshi Kaneko, Noriomi Eguchi, Ikuo Otsuka, Osamu Shirakawa, Ichiro Sora, Kyoichi Shiroiwa, Yuichiro Watanabe, Satoshi Okazaki

Publikováno v: Progress in neuro-psychopharmacologybiological psychiatry. 50

Background Genome-wide association studies (GWAS) and gene expression analyses have revealed that single nucleotide polymorphisms (SNPs) associated with multifactorial diseases, such as schizophrenia, are significantly more likely to be associated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0843e899b89ae45f261a5e22109c85
https://pubmed.ncbi.nlm.nih.gov/24361379

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Association analysis of the DISC1 gene with schizophrenia in the Japanese population and DISC1 immunoreactivity in the postmortem brain

Autor: Ichiro Sora, Akitoyo Hishimoto, Masakuni Yoshida, Kentaro Mouri, Migiwa Asano, Woraphat Ratta-apha, Irwan Supriyanto, Toru Sasada, Kyoichi Shiroiwa, Yoshimi Takai, Yasuhiro Ueno, Osamu Shirakawa, Hideru Togashi

Publikováno v: Neuroscience research. 77(4)

The Disrupted-in-Schizophrenia 1 (DISC1) gene plays a role in the regulation of neural development. Previous evidence from genetic association and biological studies implicates the DISC1 gene as having a role in the pathophysiology of schizophrenia.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f988fd7b04cd1bf40c247fabbee0f8
https://pubmed.ncbi.nlm.nih.gov/24013095

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A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients

Autor: Kentaro Mouri, Akitoyo Hishimoto, Woraphat Ratta-apha, Toru Sasada, Irwan Supriyanto, Masakuni Yoshida, Kenji Okazaki, Yuichiro Watanabe, Toshiyuki Someya, Kyoichi Shiroiwa, Noriomi Eguchi, Genki Tamiya, Osamu Shirakawa

Publikováno v: Progress in neuro-psychopharmacologybiological psychiatry. 40

Background Cell adhesion molecules (CAMs) play pivotal role in the development of the central nervous system (CNS) and have also been reported to play role in the pathophysiology of schizophrenia. Missense mutations in the CAMs genes might alter the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3369ab7e00768143256f223197715c
https://pubmed.ncbi.nlm.nih.gov/23153507

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Haplotypes in the expression quantitative trait locus of interleukin-1β gene are associated with schizophrenia

Autor: Akitoyo Hishimoto, Masaaki Fukutake, Osamu Shirakawa, Noriomi Eguchi, Kyoichi Shiroiwa, Toshiya Inada, Irwan Supriyanto, Kentaro Mouri, Woraphat Ratta-apha, Takeshi Hashimoto, Toru Sasada, Satoshi Okazaki, Hiroki Ishiguro, Masakuni Yoshida, Tadao Arinami

Publikováno v: Schizophrenia research. 140(1-3)

Recent genome-wide association study (GWAS) and gene expression analyses have revealed that single nucleotide polymorphisms (SNPs) associated with complex diseases such as schizophrenia are significantly more likely to be associated with expression q

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca6aad2a075e7bd77086a50b217d258
https://pubmed.ncbi.nlm.nih.gov/22804923

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Radiosynthesis and biodistribution in mice of a 18F-labeled analog of O-1302 for use in cerebral CB1 cannabinoid receptor imaging

Autor: Takahiro Mukai, Toru Sasada, Shintaro Tobiishi, Yumiko Nojiri, Minoru Maeda, Qinggeletu, Fumihiko Yamamoto, Kiichi Ishiwata

Publikováno v: Biologicalpharmaceutical bulletin. 31(6)

The suitability of an 18F-labeled form of N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-(4'-(5-fluoropentyl)phenyl)-4-methyl-1H-pyrazole-3-carboxamide (1), a CB1 cannabinoid ligand with high binding affinity (Ki=0.91 nM) and moderate lipophilicity (log

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019ba7834d00f11a8f167d06b9544c55
https://pubmed.ncbi.nlm.nih.gov/18520068

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