Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Toru Nakabayashi"'
Autor:
Kazuhiro Mizukami, Tatsuya Atsumi, Toru Nakabayashi, Takao Koike, Mika Yoshida, Sumiyoshi Naito, Masahiro Ieko, Kaoru Kanazawa, Masaya Mukai
Publikováno v:
International Journal of Hematology. 91:776-783
Background: The causes of thrombosis in antiphospholipid syndrome (APS) remain unknown, though several hypotheses in regard to hypofibrinolysis have been proposed. Objective: To clarify the mechanism, we measured plasma levels of thrombin-activatable
Autor:
Mika Yoshida, Harumi Sato, Yutaka Oguma, Sumiyoshi Naito, Kazuhiro Mizukami, Tomoo Yui, Masahiro Ieko, Toru Nakabayashi, Takayuhi Hirabayashi, Kaoru Kanazawa
Publikováno v:
The Tohoku Journal of Experimental Medicine. 219:25-31
Soluble fibrin monomer appears in the bloodstream during the extremely early stage of blood coagulation and generally forms a complex with fibrinogen, termed soluble fibrin monomer complex (FMC). Determination of FMC can provide information regarding
Publikováno v:
Expert Opinion on Pharmacotherapy. 9:2509-2517
Thrombin plays a key role in blood coagulation and haemostasis; thus its inhibition has been identified as a reasonable target to block the coagulation cascade. Direct thrombin inhibitors are potential prophylactic agents for venous thromboembolism a
Autor:
Mika Yoshida, Takao Koike, Sumiyoshi Naito, Masahiro Ieko, T Tarumi, Kazuhiro Mizukami, Toru Nakabayashi, Kaori Kanazawa
Publikováno v:
Clinica Chimica Acta. 386:38-45
Background Fibrin monomer (FM) and its complex (sFC) exist at high concentrations in hypercoagulable state blood. Two novel immunoassays for sFC (SF and FMC) using specific monoclonal antibodies (IF-43 and F405) were recently developed. Methods We me
Publikováno v:
Modern rheumatology. 12(1)
Antiphospholipid antibodies (aPL) are associated with an increased risk of thrombosis; however, the mechanism remains unknown. Recent studies have focused on the impediment of protein C anticoagulant activity by anti-β2-glycoprotein I (β2GPI) antib
Autor:
Norman Talal, Atsuko Sakata, John J. Letterio, Ken Mei Sakata, Howard Dang, C. Allen Lau, Toru Nakabayashi, Liping Kong, Norma Vela-Roch
Publikováno v:
Inflammation. 25:69-73
The TGF-β1(–/–) mouse is a murine model for systemic autoimmune disease. The aim of this study is to elucidate the immunological mechanism that leads to multifocal tissue inflammation and autoantibody production in TGF-β1(–/–) mice. Heart,
Autor:
Liping Kong, Howard Dang, H. Stan McGuff, Noriyoshi Ogawa, Toru Nakabayashi, Norman Talal, Norma Vela-Roch, Reiji Masago, Ken Mei Sakata
Publikováno v:
Clinical Immunology and Immunopathology. 88:133-141
To investigate the molecular mechanism of glandular parenchyma destruction in Sjögren's syndrome (SS), Bcl-2, Bax, Bcl-X, and Bak expression were studied. SS (n = 18) and control salivary glands (n = 6) were examined by immunohistochemistry. Apoptos
Autor:
Noriyoshi Ogawa, Atsuko Sakata, Howard Dang, Norman Talal, Liping Kong, Ken-Mei Sakata, Toru Nakabayashi
Publikováno v:
Japanese Journal of Rheumatology. 7:211-234
Autor:
Noriyoshi Ogawa, Errol D'Souza, George T. Liu, H. Stan McGuff, Norman Talal, Daniel Guerrero, Liping Kong, Howard Dang, Toru Nakabayashi
Publikováno v:
Arthritis & Rheumatism. 40:87-97
Objective. To assess the role of Fas-mediated apoptosis in the salivary glands of patients with primary Sjogren's syndrome (SS). Methods. Expression of Fas, Fas ligand (FasL), and bcl-2 in salivary gland biopsy material was detected in situ by immuno
Autor:
Toru Nakabayashi, Howard Dang, Norman Talal, Juan-Manuel Anaya, Eliezer Flescher, Noriyoshi Ogawa, Norma Vela-Roch, Agustin Escalante
Publikováno v:
European Journal of Immunology. 26:2006-2011
Primary Sjögren's syndrome (SS) is an autoimmune rheumatic disease characterized by T cell hypoactivity. To understand the diminished T cell response to activation signals, we measured nucleoprotein DNA-binding activities regulating gene expression