Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Toru Kontani"'
Effect of ASP2151, a Herpesvirus Helicase-Primase Inhibitor, in a Guinea Pig Model of Genital Herpes
Publikováno v:
Molecules, Vol 16, Iss 9, Pp 7210-7223 (2011)
ASP2151 is a herpesvirus helicase-primase inhibitor with antiviral activity against varicella zoster virus and herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). Here, we examined the potency and efficacy of ASP2151 against HSV in vitro and in vivo.
Externí odkaz:
https://doaj.org/article/6f6a95645a4d4d7f9182203bc6149f62
Autor:
Hiroshi Inami, Tsuyoshi Mizutani, Junko Watanabe, Hisashi Hayashida, Tomonori Ito, Takeshi Terasawa, Toru Kontani, Hiroaki Yamagishi, Hiroyuki Usuda, Naohiro Aoyama, Emiko Imamura, Takeshi Ishikawa
Publikováno v:
Bioorganic & Medicinal Chemistry. 87:117302
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb34c6f7e0328127015f225e38f84fd4
https://doi.org/10.1016/j.bmc.2023.117302
https://doi.org/10.1016/j.bmc.2023.117302
Autor:
Toru Kontani, Yoshiaki Ohtsu, Kota Kato, Koji Chono, Kiyomitsu Katsumata, Shoji Takakura, Hiroshi Suzuki
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:1339-1346
ASP2151 (amenamevir) is a helicase-primase inhibitor against herpes simplex virus 1 (HSV-1), HSV-2, and varicella zoster virus. Here, to determine and analyze the correlation between the pharmacodynamic (PD) and pharmacokinetic (PK) parameters of ASP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da69367dc83195739db7085fab4f2e57
https://doi.org/10.1128/aac.01803-12
https://doi.org/10.1128/aac.01803-12
Autor:
Hiroshi Suzuki, Toru Kontani, Kiyomitsu Katsumata, Adriana Weinberg, Shoji Takakura, Koji Chono
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:3587-3591
ASP2151 (amenamevir) is a helicase-primase inhibitor against herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus. To evaluate the anti-HSV activity of ASP2151, susceptibility testing was performed on viruses isolated from patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6188241d14870d4f114ddf3706a4261a
https://doi.org/10.1128/aac.00133-12
https://doi.org/10.1128/aac.00133-12
Effect of ASP2151, a Herpesvirus Helicase-Primase Inhibitor, in a Guinea Pig Model of Genital Herpes
Publikováno v:
Molecules; Volume 16; Issue 9; Pages: 7210-7223
Molecules
Molecules, Vol 16, Iss 9, Pp 7210-7223 (2011)
Molecules
Molecules, Vol 16, Iss 9, Pp 7210-7223 (2011)
ASP2151 is a herpesvirus helicase-primase inhibitor with antiviral activity against varicella zoster virus and herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). Here, we examined the potency and efficacy of ASP2151 against HSV in vitro and in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdd034927c05cb88c8a02281f5d7758
https://doi.org/10.3390/molecules16097210
https://doi.org/10.3390/molecules16097210
Autor:
Ayako Moritomo, Mitsuaki Ohta, Shunji Kageyama, Toru Kontani, Osamu Yamamoto, Naoyuki Masuda, Tetsuro Ohgami, Masahiro Fujii
Publikováno v:
Synthetic Communications. 35:2305-2316
Various N‐3‐alkylated thiazolidenesulfonamide derivatives were efficiently prepared by the direct endo‐selective alkylation of thiazolylsulfonamides. The effects of different bases and solvents were investigated, and the NaH–THF combination w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb157e6356debf4a1bd34704cd1d7a2
https://doi.org/10.1080/00397910500186730
https://doi.org/10.1080/00397910500186730
Autor:
Masamichi Sakai, Toru Kontani, Keishi Takeyama, Koki Takanashi, Yoshihisa Obi, Osamu Nakamura, Yoshiya Uwatoko
Publikováno v:
Japanese Journal of Applied Physics. 43:681-687
We have investigated electron transport characteristics of a hydrogen-deficient dihydride of yttrium YH2+δ (-0.3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9e419c3aaa9ffbea18bd5b66144b7e5
https://doi.org/10.1143/jjap.43.681
https://doi.org/10.1143/jjap.43.681
Autor:
Ayako Moritomo, Tadatsura Koshika, Toru Kontani, Yuji Matsushima, Hiroshi Nagata, Hisao Hamaguchi, Shinya Nagashima, Makoto Takeuchi
Publikováno v:
Bioorganicmedicinal chemistry. 22(13)
Herein, we describe the synthesis and pharmacological profiles of novel quinuclidinyl heteroarylcarbamate derivatives. Among them, the quinuclidin-4-yl thiazolylcarbamate derivative ASP9133 was identified as a promising long-acting muscarinic antagon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d551f0eec7e8cada7449e0b31443528b
https://pubmed.ncbi.nlm.nih.gov/24837158
https://pubmed.ncbi.nlm.nih.gov/24837158
Publikováno v:
Biochemical pharmacology. 84(4)
ASP2151 is an antiherpes agent targeting the helicase-primase complex of herpes simplex virus (HSV)-1, HSV-2, and varicella-zoster virus (VZV). We characterized the ASP2151-resistant HSV-1 and HSV-2 variants or mutants based on findings from sequenci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69e9103564838f3a99990022346e3a5
https://pubmed.ncbi.nlm.nih.gov/22687623
https://pubmed.ncbi.nlm.nih.gov/22687623
Autor:
Tokio Yamaguchi, Tamako Nomura, Shin-ichi Tsukamoto, Ryo Naito, Toshiyasu Mase, Tomoyuki Yasunaga, Toru Kontani
Publikováno v:
ChemInform. 28
A series of N-[2-[(substituted chroman-8-yl)oxy]ethyl]-4-(4-methoxyphenyl)butylamines was prepared and examined for their 5-HT1A receptor antagonist activity. The parent compound 3a and seven analo...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf63c4d93a57f7ee5679b04523f9058e
https://doi.org/10.1002/chin.199732118
https://doi.org/10.1002/chin.199732118