Výsledky vyhledávání - "Toru Kimitsu"

Akademický článek

Antigen Protease Activity on Intact or Tape-Stripped Skin Induces Acute Itch and T Helper Sensitization Leading to Airway Eosinophilia in Mice

Autor: Toru Kimitsu, Seiji Kamijo, Tomoko Yoshimura, Yurie Masutani, Saya Shimizu, Keiko Takada, Punyada Suchiva, Hideoki Ogawa, Ko Okumura, Shigaku Ikeda, Toshiro Takai

Publikováno v: JID Innovations, Vol 4, Iss 1, Pp 100239- (2024)

Respiratory allergen sources such as house dust mites frequently contain proteases. In this study, we demonstrated that the epicutaneous application of a model protease antigen, papain, onto intact or tape-stripped ear skin of mice induced acute scra

Externí odkaz: https://doaj.org/article/7fa8e6ed5c0746e090c1eec2d60e6f77

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Antigen protease activity with a detergent induces severe skin inflammation with itch and robust Th17/Th22 differentiation in mice

Autor: Tomoko Yoshimura, Seiji Kamijo, Saori Ichikawa, Toru Kimitsu, Yurie Masutani, Saya Shimizu, Keiko Takada, Takasuke Ogawa, Mitsutoshi Tominaga, Kenji Takamori, Hideoki Ogawa, Ko Okumura, Shigaku Ikeda, Toshiro Takai

Publikováno v: Journal of Investigative Dermatology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53833256d4e558850618a72ddc8ce5d6
https://doi.org/10.1016/j.jid.2023.03.1685

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Skin Treatment with Detergent Induces Dermatitis with H1-Antihistamine-Refractory Itch and Upregulates IL-4 and Th17/Th22 Cytokine Gene Expression in C57BL/6 Mice

Autor: Yurie Masutani, Toshiro Takai, Seiji Kamijo, Toru Kimitsu, Tomoko Yoshimura, Saori Ichikawa, Saya Shimizu, Takasuke Ogawa, Keiko Takada, Mitsutoshi Tominaga, Hajime Suto, Kenji Takamori, Hideoki Ogawa, Ko Okumura, Shigaku Ikeda

Publikováno v: International archives of allergy and immunology. 183(10)

Introduction: Repeated skin contact to detergents causes chronic irritant contact dermatitis (ICD) associated with itch sensation and eczema. However, the mechanisms of detergent-induced ICD are poorly understood. Here, we established a new murine mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d14b42ce33af23b8c1b46f14f6b870b4
https://pubmed.ncbi.nlm.nih.gov/35933977

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Epicutaneous vaccination with protease inhibitor-treated papain prevents papain-induced Th2-mediated airway inflammation without inducing Th17 in mice

Autor: Yurie Masutani, Punyada Suchiva, Toru Kimitsu, Natsuko Maruyama, Seiji Kamijo, Tomoko Yoshimura, Shigaku Ikeda, Ko Okumura, Shinya Kunimine, Hideoki Ogawa, Toshiro Takai, Saya Shimizu

Publikováno v: Biochemical and biophysical research communications. 546

Environmental allergen sources such as house dust mites contain proteases, which are frequently allergens themselves. Inhalation with the exogenous proteases, such as a model of protease allergen, papain, to airways evokes release and activation of I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8564bb3a51a89df6623caacdd247ed41
https://pubmed.ncbi.nlm.nih.gov/33618285

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