Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Toru Hosoi"'
Autor:
Tadashi Nakagawa, Toru Hosoi
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Organismal energy balance is controlled by inter-tissue communication mediated by the nervous system and hormones, the disruption of which causes metabolic syndrome exemplified by diabetes and obesity. Fat-storing adipose tissue, especially those loc
Externí odkaz:
https://doaj.org/article/c12e718f36e84253ad30247bc4fd0ea3
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
Genomic analysis has revealed that the genes for various chromatin regulators are mutated in many individuals with neurodevelopmental disorders (NDDs), emphasizing the important role of chromatin regulation in nervous system development and function.
Externí odkaz:
https://doaj.org/article/220e7714b9a447b5a624ba44132757de
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Neuroimmune interactions between the immune system and CNS as well as peripheral organs such as the liver play a key role in the pathophysiological state of diseases. Unfolded protein responses (UPRs), which are activated by cells in response to endo
Externí odkaz:
https://doaj.org/article/38b957b1383f443a94ca29e3dd263128
Autor:
Tadashi Nakagawa, Akane Morohoshi, Yuko Nagasawa, Makiko Nakagawa, Masaki Hosogane, Yasuhiro Noda, Toru Hosoi, Keiko Nakayama
Publikováno v:
Cell Reports, Vol 38, Iss 12, Pp 110541- (2022)
Summary: The histone chaperone complex FACT comprises SPT16 and SSRP1 and contributes to DNA replication, transcription, and repair, but how it plays such various roles is unclear. Here, we show that human SPT16 is ubiquitylated at lysine-674 (K674)
Externí odkaz:
https://doaj.org/article/acc2ec7278fc475baaf6a4baafc163bc
Autor:
Arini Isnani Preninka, Karen Kuriya, Kyosuke Yazawa, Michiko Yoshii, Yuhki Yanase, Ralf Jockers, Julie Dam, Toru Hosoi, Koichiro Ozawa
Publikováno v:
PLoS ONE, Vol 17, Iss 12 (2022)
Abnormally high serum homocysteine levels have been associated with several disorders, including obesity, cardiovascular diseases or neurological diseases. Leptin is an anti-obesity protein and its action is mainly mediated by the activation of its O
Externí odkaz:
https://doaj.org/article/2fbd4a84bb824dbe952a9169e3ce8c2e
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Myeloid differentiation primary response 88 (MyD88) is an adapter protein of the toll-like receptor (TLR) family that regulates innate immune function. Here, we identified a novel role of MyD88 in regulating stress response. MyD88 deficiency decrease
Externí odkaz:
https://doaj.org/article/9cdd5db6dae0457e960fe7009653d4d5
Autor:
Toru Hosoi, Shinsuke Ino, Fumie Ohnishi, Kenichi Todoroki, Michiko Yoshii, Mai Kakimoto, Christa E. Müller, Koichiro Ozawa
Publikováno v:
Immunity, Inflammation and Disease, Vol 6, Iss 1, Pp 97-105 (2018)
Abstract Introduction Mast cells play an important role in allergic responses. Methods We herein demonstrated the mechanisms of inhibitory effect of adenine on IgE/antigen‐induced degranulation and TNF‐α release in mast cells. Results We found t
Externí odkaz:
https://doaj.org/article/c8e2e2edd5ce4754ad76e2414bb0869b
Autor:
Virginie Vauthier, Clara Roujeau, Patty Chen, Chamsy Sarkis, Stéphanie Migrenne, Toru Hosoi, Koichiro Ozawa, Yves Rouillé, Marc Foretz, Jacques Mallet, Jean-Marie Launay, Christophe Magnan, Ralf Jockers, Julie Dam
Publikováno v:
Molecular Metabolism, Vol 6, Iss 1, Pp 159-172 (2017)
The hypothalamic arcuate nucleus (ARC) is a major integration center for energy and glucose homeostasis that responds to leptin. Resistance to leptin in the ARC is an important component of the development of obesity and type 2 diabetes. Recently, we
Externí odkaz:
https://doaj.org/article/65aa9e761d8b42dc951f394b44f85b58
Autor:
Kristina Wardelmann, Michaela Rath, José Pedro Castro, Sabine Blümel, Mareike Schell, Robert Hauffe, Fabian Schumacher, Tanina Flore, Katrin Ritter, Andreas Wernitz, Toru Hosoi, Koichiro Ozawa, Burkhard Kleuser, Jürgen Weiß, Annette Schürmann, André Kleinridders
Publikováno v:
Antioxidants, Vol 10, Iss 5, p 711 (2021)
Mitochondria are critical for hypothalamic function and regulators of metabolism. Hypothalamic mitochondrial dysfunction with decreased mitochondrial chaperone expression is present in type 2 diabetes (T2D). Recently, we demonstrated that a dysregula
Externí odkaz:
https://doaj.org/article/9db7b1040f554f3f80b1b7f6dd84a90e
Publikováno v:
Journal of Pharmacological Sciences, Vol 131, Iss 4, Pp 292-295 (2016)
A pharmacological approach to ameliorate Alzheimer's disease (AD) has not yet been established. In the present study, we investigated the pharmacological characteristics of the recently identified memory-enhancing compound, ISRIB for the amelioration
Externí odkaz:
https://doaj.org/article/afa03c346a17404ca04b281fd5ac1f72