Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Toru Hoshiya"'
Autor:
Yachiyo Fukunaga, Toru Hoshiya, Yuko Yamaguchi, Kazutoshi Tamura, Tsubasa Saito, Mizuho Takagi
Publikováno v:
Journal of Toxicologic Pathology
5-Fluorouracil (5-Fu) is a DNA-damaging agent and teratogenic in rodents. This study aimed to investigate its influence on neural progenitor cells (NPCs) in the developing fetal rat brain. Dams were intraperitoneally injected with 5-Fu (50 mg/kg b.w.
Publikováno v:
Journal of Toxicologic Pathology
Extraskeletal osteosarcoma is a very rare tumor in humans and animals. This paper describes a case of extraskeletal osteosarcoma observed in the duodenum of a male ICR mouse. Grossly, a solid mass pushing up the tunica serosa was observed in the duod
Autor:
Yuko Yamaguchi, Shunji Nakatsuji, Natsumi Shimoyama, Kazutoshi Tamura, Rie Andoh, Toru Hoshiya
Publikováno v:
Toxicologic Pathology. 43:675-680
Intranuclear and cytoplasmic inclusions in the renal proximal tubular epithelium were observed in nontreated male and female Wistar Hannover rats in a 26-week study (32 weeks of age) and a 104-week study (110 weeks of age). The incidence rates were l
Publikováno v:
Journal of Toxicologic Pathology
Busulfan is an antineoplastic bifunctional alkylating agent. We previously reported the busulfan-induced systemic histopathological changes in fetal rats and the sequence of brain lesions in fetal and infant rats. In the present study, in order to cl
Autor:
Kayoko Kudo, Mariko Nagatani, Isamu Suzuki, Seiki Yamakawa, Toru Hoshiya, Shinichiro Ikezaki, Kazuyuki Uchida, Toko Ohira, Yuko Yamaguchi, Kazutoshi Tamura, Tsubasa Saito
Publikováno v:
Journal of Toxicologic Pathology
In order to accurately assess the carcinogenicity of chemicals with regard to rare tumors such as rat CNS tumors, sufficient information about spontaneous tumors are very important. This paper presents the data on the type, incidence and detected age
Autor:
Kayoko Kudo, John C. Seely, Tomomi Nakazawa, Tsubasa Saito, Isamu Suzuki, Kazutoshi Tamura, Natsumi Shimoyama, Toru Hoshiya
Publikováno v:
Journal of Toxicologic Pathology
Spontaneous renal tubule tumors (RTTs), with a distinctive morphological phenotype, were present in three Sprague-Dawley rats, 1 male and 2 females, out a total of 120 animals of each sex from untreated and placebo control groups in a 2-year carcinog
Autor:
Kazuyuki Uchida, Kazutoshi Tamura, Tsubasa Saito, Seiki Yamakawa, Ryo Ando, Mariko Nagatani, Toru Hoshiya
Publikováno v:
Toxicologic Pathology. 41:653-661
It is generally said that neoplastic cells are immunohistochemically negative for glial fibrillary acidic protein (GFAP) in rat spontaneous astrocytomas, and there are no reports describing the existence of GFAP-positive neoplastic astrocytes in rat
Autor:
Tatsuya Ogawa, Toshiya Okamura, Kazutoshi Tamura, Masahiro Mochizuki, Shuzo Okazaki, Osamu Kusuoka, Junichi Kobayashi, Toru Hoshiya, Kazuhisa Hatayama, Saori Suzuki
Publikováno v:
Journal of Toxicologic Pathology
Recently, RccHan(TM):WIST (Wistar Hannover) rats were introduced to toxicity studies in Japan. The present study was performed to obtain control data for general toxicological parameters as an aid for interpretation of results in toxicity studies usi
Autor:
Azusa Okaniwa, Dai Watanabe, Makoto Ishigami, Hiroyasu Mizuguchi, Toshiya Ishii, Hisako Hori, Toshifumi Oyamada, Toru Hoshiya, Tsutomu Ishikawa
Publikováno v:
The Journal of Toxicological Sciences. 33:241-244
In order to prepare background data for toxicity studies, serum alkaline phosphatase activity in a total of 5,242 male and female beagle dogs was surveyed for the sequence of changes in activity through aging. About 95% of the beagle dogs surveyed we
Autor:
Azusa Okaniwa, Yuko Yamaguchi, Hiroyasu Yoshikawa, Dai Watanabe, Junko Sato, Kohsuke Horiguchi, Toru Hoshiya, Yoshikazu Nagashima
Publikováno v:
Journal of Toxicologic Pathology. 19:169-177
In order to prepare background data for toxicity studies, reproductive organs of a total of 106 purpose-bred female cynomolgus monkeys 2.0 to 9.0 years of age were surveyed for the sequence of events during reproductive cycles. Based on histological