Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Toru Akaike"'
Publikováno v:
Pediatrics and Neonatology, Vol 61, Iss 1, Pp 45-50 (2020)
Background: Rates of patent ductus arteriosus (PDA) and infection are high in preterm infants. Preterm infants with infection are more likely to develop symptomatic PDA, a potentially fatal disease. Clinically, gentamicin is widely used for early-ons
Externí odkaz:
https://doaj.org/article/38a3854df9d3404ca6f7ebe73cc005eb
Autor:
Kazuhiro Kuga, Yoichiro Kusakari, Ken Uesugi, Kentaro Semba, Takashi Urashima, Toru Akaike, Susumu Minamisawa
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231905 (2020)
Myocardial fibrosis is often associated with cardiac hypertrophy; indeed, fibrosis is one of the most critical factors affecting prognosis. We aimed to identify the molecules involved in promoting fibrosis under hypertrophic stimuli. We previously es
Externí odkaz:
https://doaj.org/article/e064458f725645a9aba63650a369a1ce
Autor:
Toru Akaike, MD, PhD, Na Du, MD, PhD, Gang Lu, PhD, Susumu Minamisawa, MD, PhD, Yibin Wang, PhD, Hongmei Ruan, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 2, Pp 160-180 (2017)
Summary: Phospholamban (PLN) is a key regulator of sarcolemma calcium uptake in cardiomyocyte; its inhibitory activity to sarcolemma-endoplasmic reticulum calcium ATPase is regulated by phosphorylation. PLN hypophosphorylation is a common molecular f
Externí odkaz:
https://doaj.org/article/60c8611e611e40c891e848de973f9857
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0214139 (2019)
The ductus arteriosus, an essential embryonic blood vessel between the pulmonary artery and the descending aorta, constricts after birth or hatching and eventually closes to terminate embryonic circulation. Chicken embryos have two long ductus arteri
Externí odkaz:
https://doaj.org/article/ef7a813d3d9c4f48b47553ba0ded69f5
Autor:
Yoichiro Kusakari, Takashi Urashima, Daisuke Shimura, Erika Amemiya, Genki Miyasaka, Shunsuke Yokota, Yoshitaka Fujimoto, Toru Akaike, Takahiro Inoue, Susumu Minamisawa
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169564 (2017)
Interstitial myocardial fibrosis is one of the factors responsible for dysfunction of the heart. However, how interstitial fibrosis affects cardiac function and excitation-contraction coupling (E-C coupling) has not yet been clarified. We developed a
Externí odkaz:
https://doaj.org/article/0af6335c3e7a42c69bb60fc8f4108a91
Autor:
Yoshitaka Fujimoto, Takashi Urashima, Daisuke Shimura, Reiji Ito, Sadataka Kawachi, Ichige Kajimura, Toru Akaike, Yoichiro Kusakari, Masako Fujiwara, Kiyoshi Ogawa, Nobuhito Goda, Hiroyuki Ida, Susumu Minamisawa
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148666 (2016)
BACKGROUND:Hepatic fibrosis progresses with right heart failure, and becomes cardiac cirrhosis in a severe case. Although its causal factor still remains unclear. Here we evaluated the progression of hepatic fibrosis using a pulmonary artery banding
Externí odkaz:
https://doaj.org/article/91d85b372bbc4a8eb84c7587a2ca18c9
Autor:
Toru Akaike, Yukihiro Kaneko, Susumu Minamisawa, Gen Shinohara, Hironori Matsuhisa, Ryuma Iwaki, Kiyozo Morita, Masashi Takahashi, Takuro Tsukube, Masato Hoshino, Naoto Yagi, Syuichi Yoshitake, Yoshihiro Oshima
Publikováno v:
Pediatric Cardiology. 42:654-661
We assessed the histological accuracy of X-ray phase-contrast tomography (XPCT) and investigated three-dimensional (3D) ductal tissue distribution in coarctation of the aorta (CoA) specimens. We used nine CoA samples, including the aortic isthmus, du
Publikováno v:
Circulation. 144
Introduction: We have previously reported that the atrial cardiomyocyte-specific Pitx2c overexpression impaired sinus node function. It is well known that sinus node dysfunction is associated with atrial fibrillation (AF) and PITX2C increases in pati
Publikováno v:
The FASEB Journal. 35
Publikováno v:
Circulation Journal. 83:209-216
BACKGROUND Patent ductus arteriosus (PDA) is common in premature infants. Cyclooxygenase inhibitors such as indomethacin, which inhibit prostaglandin E2(PGE2) synthesis, are currently the sole treatments for patients with PDA. Their efficacy are, how