Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Toru, Nishinaka"'
Autor:
Kahori Shimizu, Syogo Nishimuta, Yuri Fukumura, Shotaro Michinaga, Yuka Egusa, Tomomi Hase, Tomoyuki Terada, Fuminori Sakurai, Hiroyuki Mizuguchi, Koji Tomita, Toru Nishinaka
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274297 (2022)
The liver is the main organ that regulates lipid and glucose metabolism. Ectopic lipid accumulation in the liver impairs insulin sensitivity and glucose metabolism. Lipoprotein lipase (LPL), mainly expressed in the adipose tissue and muscle, is a key
Externí odkaz:
https://doaj.org/article/43b57908284e46f9960d1a8ccb6ca095
Autor:
Mai Aoe, Seiji Esaki, Masahiro Ikejiri, Takuya Ito, Katsuhito Nagai, Yasutoshi Hatsuda, Yoshimi Hirokawa, Tomohisa Yasuhara, Takehiko Kenzaka, Toru Nishinaka
Publikováno v:
Pharmacy, Vol 11, Iss 1, p 16 (2023)
During the coronavirus disease 2019 (COVID-19) pandemic, online-based learning has become mainstream in many countries, and its learning outcomes have been evaluated. However, various studies have shown that online-based learning needs to be optimize
Externí odkaz:
https://doaj.org/article/51fa969e345c45258186cba1e0224695
Autor:
Takaomi Shimokawa, Hidenobu Tsutsui, Takeshi Miura, Masashi Takama, Kohei Hayashi, Toru Nishinaka, Tomoyuki Terada, Kozo Yoneda, Masayo Yamagata, Tokihito Yukimura
Publikováno v:
Journal of Pharmacological Sciences, Vol 139, Iss 3, Pp 137-142 (2019)
Ischemia/reperfusion injury is the most common cause of acute kidney injury. We previously revealed that pre-treatment with yohimbine or JP-1302 attenuated renal ischemia/reperfusion injury by inhibition of α2C-adrenoceptor antagonist. The aim of th
Externí odkaz:
https://doaj.org/article/128eb550d8d84b08829cfa8308a52125
Autor:
Kahori Shimizu, Minako Okamoto, Tomoyuki Terada, Fuminori Sakurai, Hiroyuki Mizuguchi, Koji Tomita, Toru Nishinaka
Publikováno v:
Biochemistry and Biophysics Reports, Vol 10, Iss C, Pp 192-197 (2017)
Japanese patients with type 2 diabetes mellitus present a different responsiveness in terms of insulin secretion to glucose and body mass index (BMI) from other populations. The genetic background that predisposes Japanese individuals to type 2 diabe
Externí odkaz:
https://doaj.org/article/ab4e7c3304de4a79af9472b7db76a604
Publikováno v:
Metabolites, Vol 11, Iss 6, p 332 (2021)
AKR1B10 is a human nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reductase belonging to the aldo-keto reductase (AKR) 1B subfamily. It catalyzes the reduction of aldehydes, some ketones and quinones, and interacts with acetyl-CoA carb
Externí odkaz:
https://doaj.org/article/d5e8c3641e8c42688902b5d39e5fa5dd
Autor:
Fumitaka Nishimae, Shinichiro Nakamura, Ryosuke Ono, Shunsuke Iizuka, Hiroyuki Mizuguchi, Tomohito Tsukamoto, Kahori Shimizu, Toru Nishinaka, Yasushi Fujio, Fuminori Sakurai, Tomoyuki Terada
Publikováno v:
The Journal of Immunology. 206:410-421
Adenovirus (Ad) vector–mediated transduction can cause hepatotoxicity during two phases, at ∼2 and 10 days after administration. Early hepatotoxicity is considered to involve inflammatory cytokines; however, the precise mechanism remains to be cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c59710302f9bddc36e4edfd5786781
https://doi.org/10.4049/jimmunol.2000830
https://doi.org/10.4049/jimmunol.2000830
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 221
Most members of the aldo-keto reductase (AKR) 1 C subfamily are hydroxysteroid dehydrogenases (HSDs). Similarly to humans, four genes for AKR1C proteins (AKR1C1-AKR1C4) have been identified in the pig, which is a suitable species for biomedical resea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5b6214b57b6b9be60666eb61f18ebb
https://pubmed.ncbi.nlm.nih.gov/35398259
https://pubmed.ncbi.nlm.nih.gov/35398259
Autor:
Kazumi Iwata, Toru Nishinaka, Kuniharu Matsuno, Tomoko Kakehi, Masato Katsuyama, Masakazu Ibi, Chihiro Yabe-Nishimura
Publikováno v:
Journal of Pharmacological Sciences, Vol 103, Iss 4, Pp 408-416 (2007)
The importance of aldose reductase (AR) has been implicated in the pathogenesis of diabetic complications, although the alterations in the expression and activity of AR during hyperglycemia in the heart have not been well characterized. We investigat
Externí odkaz:
https://doaj.org/article/bb78a335472b419092cff6fa4326ffb7
Publikováno v:
Journal of Pharmacological Sciences, Vol 102, Iss 1, Pp 37-46 (2006)
Aldose reductase (AR) has been implicated in the pathogenesis of diabetic complications, although the clinical efficacy of AR inhibitors has not been clearly proven. To clarify the pathophysiological role of AR in the heart, we investigated effects o
Externí odkaz:
https://doaj.org/article/f258459743814aee94a5e05c2eb8a7c9
Autor:
Toru Nishinaka, Chihiro Yabe-Nishimura
Publikováno v:
Journal of Pharmacological Sciences, Vol 97, Iss 1, Pp 43-51 (2005)
Transcription factor Nrf2 regulates gene expression of drug metabolizing enzymes such as glutathione S-transferase via the antioxidant response element, ARE. Aldose reductase (AR), a member of the aldo-keto reductase (AKR) superfamily, metabolizes va
Externí odkaz:
https://doaj.org/article/eaca293f44104d9e89b4851c854dfc14