Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Toru, Hirao"'
Autor:
Koki Hirashima, Yuichi Kitai, Shigeyuki Kon, Keisuke Tawa, Ryuta Muromoto, Toru Hirao, Tadashi Matsuda
Publikováno v:
International Immunology. 28:443-452
In psoriasis lesions, a diverse mixture of cytokines is up-regulated that influence each other generating a complex inflammatory situation. Although this is the case, the inhibition of IL-17A alone showed unprecedented clinical results in patients, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30914669130be446e1a2b2b8d03c3f6f
https://doi.org/10.1093/intimm/dxw011
https://doi.org/10.1093/intimm/dxw011
Autor:
Shinji Takeuchi, Hiroyuki Kojima, Yukimasa Takeda, Tadashi Matsuda, Anton M. Jetten, Miki Takahashi, Ryuta Muromoto, Toru Hirao
Publikováno v:
Toxicology. 329:32-39
The retinoic acid receptor-related orphan receptors α and γ (RORα and RORγ), are key regulators of helper T (Th)17 cell differentiation, which is involved in the innate immune system and autoimmune disorders. In this study, we investigated the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21fae20c5d558fafd92b2ce93a49af6
https://doi.org/10.1016/j.tox.2015.01.007
https://doi.org/10.1016/j.tox.2015.01.007
Autor:
Hiroshi Abe, Satoshi Shuto, Kotaro Matsubara, Mitsuhiro Arisawa, Makoto Tanabe, Koki Hirashima, Tadashi Matsuda, Yuuki Takakura, Hayato Fukuda, Daichi Fushihara, Kohei Ishimura, Ryuta Muromoto, Toru Hirao, Ryutaro Kanada
Publikováno v:
Organic letters. 18(24)
Lipid chemical mediator resolvins with highly potent anti-inflammatory activity can be leads to develop novel anti-inflammatory drugs; however, they are unstable in oxygen due to their characteristic polyunsaturated structures. To solve the problem,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f713508e0e0b17a6bc9858263c0afd7
https://pubmed.ncbi.nlm.nih.gov/27978690
https://pubmed.ncbi.nlm.nih.gov/27978690
Autor:
Hiroshi Tamagami, Takemi Watanabe, Kiyoshi Morimoto, Takashi Ninomiya, Toru Hirao, Takako Onishi, Akihiro Tanaka
Publikováno v:
Epilepsy Research. 61:113-118
[ 123 I]Iomazenil (IMZ) is a specific ligand for central-type benzodiazepine receptors (BZRs) and is available for single photon emission computed tomography (SPECT) to detect epileptogenic foci. We have recently demonstrated time-dependent alteratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4f0daa18517a6b88a920dfeac48a8b
https://doi.org/10.1016/j.eplepsyres.2004.07.006
https://doi.org/10.1016/j.eplepsyres.2004.07.006
Autor:
Hiroshi Tamagami, Kiyoshi Morimoto, Miki Kakumoto, Akihiro Tanaka, Takashi Ninomiya, Toru Hirao, Takemi Watanabe
Publikováno v:
Epilepsy Research. 61:105-112
This study aimed at quantitatively evaluating hippocampal central-type benzodiazepine receptors (BZRs) in the kainate model of temporal lobe epilepsy (TLE) by in vitro autoradiography (ARG) using [(125)I] Iomazenil (IMZ) specific ligand for central-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::925252a01e346ca5857a088bba9a8ad4
https://doi.org/10.1016/j.eplepsyres.2004.07.011
https://doi.org/10.1016/j.eplepsyres.2004.07.011
Autor:
Toru Hirao, Nobuo Ando, Kiyoshi Morimoto, Takashi Ninomiya, Hiroshi Suwaki, Mitsuo Nakamura, Takemi Watanabe
Publikováno v:
Brain Research. 1003:194-198
Kindling of the ventral tegmental area (VTA), a major source of the mesolimbic dopamine pathway, was examined in rats. We applied two quantitative measurements of dopamine sensitivity before and 2 weeks after VTA kindling (20 times electrical stimula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbac781cc2b7be6a9de3057cb12ad96
https://doi.org/10.1016/j.brainres.2004.01.006
https://doi.org/10.1016/j.brainres.2004.01.006
Autor:
Toru Hirao, Yoshitaka Yamamoto, Norihito Yamada, Keiko Sato, Koichi Tanaka, Kiyoshi Morimoto, Soichiro Sato, Hitoshi Sato, Takemi Watanabe, Hiroshi Suwaki
Publikováno v:
Molecular Brain Research. 54:49-55
To investigate the role played by GABA transporters in epileptic seizures, we examined time-dependent and regional changes in expression of GAT-1 and GAT-3 GABA transporter mRNA in amygdala-kindled rat brain using an in situ hybridization method. GAT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e494cd090ea9d787c5de310954a01082
https://doi.org/10.1016/s0169-328x(97)00323-9
https://doi.org/10.1016/s0169-328x(97)00323-9
Publikováno v:
Journal of Dermatological Science. 84:e97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09201546346e4bd0912b565a8f7f6ac4
https://doi.org/10.1016/j.jdermsci.2016.08.293
https://doi.org/10.1016/j.jdermsci.2016.08.293
Autor:
Toru, Hirao
Publikováno v:
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. 113(10)
Following recent dissemination of various guidelines and algorithms and spread of second-generation antipsychotics, the view laying emphasis on "single antipsychotic regimen" has been well known as far as drug therapy for schizophrenia is concerned.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb7313c38cc9969fab733df6add16d50
https://pubmed.ncbi.nlm.nih.gov/22187892
https://pubmed.ncbi.nlm.nih.gov/22187892
Autor:
Takemi Watanabe, Ryosuke Miyatake, Toru Hirao, Hiroshi Suwaki, Mitsuo Nakamura, Kiyoshi Morimoto
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 26(6)
Since delusional disorder is characterized by mono-symptomatic paranoid symptoms, it can be a good clinical model for investigating the dopaminergic mechanism responsible for paranoid symptoms. We examined neuroleptic responses, plasma homovanillic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692593fb6193248dbb73e06a5bc2ccb2
https://pubmed.ncbi.nlm.nih.gov/12007750
https://pubmed.ncbi.nlm.nih.gov/12007750