Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Torsten Unge"'
Publikováno v:
Acta Crystallographica Section D Structural Biology. 74:711-712
Autor:
Xavier de Lamballerie, Bruno Canard, Ernest A. Gould, Erika J. Mancini, Rene Assenberg, Silvia Speroni, Hélène Malet, Gregory Moureau, Anna M. Jansson, Martino Bolognesi, Barbara Selisko, Johan Neyts, Rolf Hilgenfeld, Michela Bollati, Jonathan M. Grimes, Raymond J. Owens, David I. Stuart, Bruno Coutard, Mario Milani, Holger Steuber, Andrea Mattevi, Eloise Mastrangelo, Jingshan Ren, Cécile Baronti, Etienne Decroly, Torsten Unge, Karin Alvarez, Shelley Cook, Gilda Grard
Publikováno v:
Antiviral Research
Antiviral research
87 (2010): 125–148. doi:10.1016/j.antiviral.2009.11.009
info:cnr-pdr/source/autori:Bollati M.; K. Alvarez; R. Assenberg; C. Baronti; B. Canard; S. Cook; B. Coutard; E. Decroly; X. de Lamballerie; E.A. Gould; G. Grard; J.M. Grimes; R. Hilgenfeld; A.M. Jansson; H. Malet; E.J. Mancini; E. Mastrangelo; A. Mattevi; M. Milani; G. Moureau, J./titolo:Structure and functionality in flavivirus NS-proteins: Perspectives for drug design/doi:10.1016%2Fj.antiviral.2009.11.009/rivista:Antiviral research (Print)/anno:2010/pagina_da:125/pagina_a:148/intervallo_pagine:125–148/volume:87
Antiviral research
87 (2010): 125–148. doi:10.1016/j.antiviral.2009.11.009
info:cnr-pdr/source/autori:Bollati M.; K. Alvarez; R. Assenberg; C. Baronti; B. Canard; S. Cook; B. Coutard; E. Decroly; X. de Lamballerie; E.A. Gould; G. Grard; J.M. Grimes; R. Hilgenfeld; A.M. Jansson; H. Malet; E.J. Mancini; E. Mastrangelo; A. Mattevi; M. Milani; G. Moureau, J./titolo:Structure and functionality in flavivirus NS-proteins: Perspectives for drug design/doi:10.1016%2Fj.antiviral.2009.11.009/rivista:Antiviral research (Print)/anno:2010/pagina_da:125/pagina_a:148/intervallo_pagine:125–148/volume:87
Flaviviridae are small enveloped viruses hosting a positive-sense single-stranded RNA genome. Besides yellow fever virus, a landmark case in the history of virology, members of the Flavivirus genus, such as West Nile virus and dengue virus, are incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3100478119ff8862457b51960b0d0797
https://doi.org/10.1016/j.antiviral.2009.11.009
https://doi.org/10.1016/j.antiviral.2009.11.009
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 68:134-143
A number of pathogens, including the causative agents of tuberculosis and malaria, synthesize the essential isoprenoid precursor isopentenyl diphosphate via the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway rather than the classical mevalonate
Autor:
C. Bjorkelid, Mats Larhed, Anders Karlén, Sherry L. Mowbray, Anna Więckowska, Surisetti Suresh, Mounir Andaloussi, Torsten Unge, Terese Bergfors, Harini Iyer, T. Alwyn Jones, Martin Lindh, Bachally R. Srinivasa, L.M. Henriksson, Anna M. Larsson
Publikováno v:
Journal of Medicinal Chemistry. 54:4964-4976
The natural antibiotic fosmidomycin acts via inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), an essential enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. Fosmidomycin is active on Mycobacterium tuberculosis DXR (
Autor:
Torsten Unge, Henrik Ingvarsson
Publikováno v:
FEBS Journal. 277:3947-3962
Two structures of monomeric methionyl-tRNA synthetase, from Mycobacterium smegmatis, in complex with the ligands methionine/adenosine and methionine, were analyzed by X-ray crystallography at 2.3 A and at 2.8 A, respectively. The structures demonstra
Autor:
Jacques Rohayem, Torsten Unge, Mirko Bergmann, Andrea Mattevi, Johan Neyts, Julia Gebhardt, Rolf Hilgenfeld, Paul A. Tucker, Ernest A. Gould
Publikováno v:
Antiviral Research
Caliciviridae are human or non-human pathogenic viruses with a high diversity. Some members of the Caliciviridae, i.e. human pathogenic norovirus or rabbit hemorrhagic disease virus (RHDV), are worldwide emerging pathogens. The norovirus is the major
Autor:
Johanna Nurbo, Daniel Muthas, Torsten Unge, Gunnar Lindeberg, Daniel J. Ericsson, Anders Karlén, Kalle Hertzberg
Publikováno v:
Journal of Peptide Science. 16:159-164
Ribonucleotide reductase (RNR) is a viable target for new drugs against the causative agent of tuberculosis, Mycobacterium tuberculosis. Previous work has shown that an N-acetylated heptapeptide based on the C-terminal sequence of the smaller RNR sub
Autor:
Bertil Samuelsson, Jenny K. Ekegren, Mats Larhed, Linda Axelsson, Hans Wallberg, Jacob Kihlström, Anders Hallberg, Johan Wannberg, Torsten Unge, A. K. Mahalingam
Publikováno v:
Journal of Medicinal Chemistry. 53:607-615
By a small modification in the core structure of the previously reported series of HIV-1 protease inhibitors that encompasses a tertiary alcohol as part of the transition-state mimicking scaffold, up to 56 times more potent compounds were obtained ex
Autor:
Nadia Benaroudj, Martin Högbom, Henrik Ingvarsson, Miguel Ortiz-Lombardía, Maria J. Maté, Torsten Unge, Denis Portnoi, Pedro M. Alzari
Publikováno v:
Acta Crystallographica Section D: Biological Crystallography
Acta Crystallographica Section D: Biological Crystallography, International Union of Crystallography, 2007, 63 (Pt 2), pp.249-59. ⟨10.1107/S0907444906050530⟩
Acta crystallographica Section D : Structural biology [1993-...]
Acta crystallographica Section D : Structural biology [1993-..], 2007, 63 (Pt 2), pp.249-59. ⟨10.1107/S0907444906050530⟩
Acta Crystallographica Section D: Biological Crystallography, International Union of Crystallography, 2007, 63 (Pt 2), pp.249-59. ⟨10.1107/S0907444906050530⟩
Acta crystallographica Section D : Structural biology [1993-...]
Acta crystallographica Section D : Structural biology [1993-..], 2007, 63 (Pt 2), pp.249-59. ⟨10.1107/S0907444906050530⟩
International audience; Mycobacterium tuberculosis caseinolytic protease ClpP1 (Mt ClpP1) is a self-compartmentalized protease consisting of two heptameric rings stacked on top of each other, thus enclosing a catalytic chamber. Within the chamber, wh
Autor:
Torbjörn Lundstedt, Torsten Unge, Daniel Muthas, Johanna Nurbo, Annette K. Roos, Erik Wahlström, Daniel J. Ericsson, Anders Karlén
Publikováno v:
Journal of Peptide Science. 13:822-832
Mycobacterium tuberculosis ribonucleotide reductase (RNR) is a potential target for new antitubercular drugs. Herein we describe the synthesis and evaluation of peptide inhibitors of RNR derived from the C-terminus of the small subunit of M. tubercul