Zobrazeno 1 - 10
of 358
pro vyhledávání: '"Torsten O, Nielsen"'
Autor:
Amir Pozner, Li Li, Shiv Prakash Verma, Shuxin Wang, Jared J. Barrott, Mary L. Nelson, Jamie S. E. Yu, Gian Luca Negri, Shane Colborne, Christopher S. Hughes, Ju-Fen Zhu, Sydney L. Lambert, Lara S. Carroll, Kyllie Smith-Fry, Michael G. Stewart, Sarmishta Kannan, Bodrie Jensen, Cini M. John, Saif Sikdar, Hongrui Liu, Ngoc Ha Dang, Jennifer Bourdage, Jinxiu Li, Jeffery M. Vahrenkamp, Katelyn L. Mortenson, John S. Groundland, Rosanna Wustrack, Donna L. Senger, Franz J. Zemp, Douglas J. Mahoney, Jason Gertz, Xiaoyang Zhang, Alexander J. Lazar, Martin Hirst, Gregg B. Morin, Torsten O. Nielsen, Peter S. Shen, Kevin B. Jones
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The t(X,17) chromosomal translocation, generating the ASPSCR1::TFE3 fusion oncoprotein, is the singular genetic driver of alveolar soft part sarcoma (ASPS) and some Xp11-rearranged renal cell carcinomas (RCCs), frustrating efforts to identif
Externí odkaz:
https://doaj.org/article/22b004d19a254382bdb0a79d65c8bcf2
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-26 (2022)
Abstract As the field of translational ‘omics has progressed, refined classifiers at both genomic and proteomic levels have emerged to decipher the heterogeneity of breast cancer in a clinically-applicable way. The integration of ‘omics knowledge
Externí odkaz:
https://doaj.org/article/f43d3203f61a424886e449ad800bd237
Autor:
Karama Asleh, Gian Luca Negri, Sandra E. Spencer Miko, Shane Colborne, Christopher S. Hughes, Xiu Q. Wang, Dongxia Gao, C. Blake Gilks, Stephen K. L. Chia, Torsten O. Nielsen, Gregg B. Morin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Protein level information enables the identification of potential biomarkers and therapeutic targets for breast cancer. Here, the authors perform proteomic analysis of 2 cohorts of breast cancer surgical specimens and identify distinct subtypes, immu
Externí odkaz:
https://doaj.org/article/721684907354410998201013bf23a946
Autor:
Karama Asleh, Nazia Riaz, Angela S. Cheng, Dongxia Gao, Samuel C. Y. Leung, Meenakshi Anurag, Torsten O. Nielsen
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-13 (2021)
Abstract Precise biomarkers are needed to guide better diagnostics and therapeutics for basal-like breast cancer, for which DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has been recently reported by the Clinical Proteomic Tumor Analysis
Externí odkaz:
https://doaj.org/article/50da77342af4406d9748983cb7210dc1
Autor:
Nikita Patel, Juehong Wang, Kumiko Shiozawa, Kevin B. Jones, Yanfeng Zhang, Jeremy W. Prokop, George G. Davenport, Naoe T. Nihira, Zhenyue Hao, Derek Wong, Laurel Brandsmeier, Sarah K. Meadows, Arthur V. Sampaio, Ryan Vander Werff, Makoto Endo, Mario R. Capecchi, Kelly M. McNagny, Tak W. Mak, Torsten O. Nielsen, T. Michael Underhill, Richard M. Myers, Tadashi Kondo, Le Su
Publikováno v:
iScience, Vol 13, Iss , Pp 43-54 (2019)
Summary: Histone deacetylases (HDACs) are promising targets for cancer therapy, although their individual actions remain incompletely understood. Here, we identify a role for HDAC2 in the regulation of MDM2 acetylation at previously uncharacterized l
Externí odkaz:
https://doaj.org/article/86168b789a6f460780d4cbfa71bccd3c
Autor:
Torsten O. Nielsen
Publikováno v:
McGill Journal of Medicine, Vol 3, Iss 2 (2020)
N/A
Externí odkaz:
https://doaj.org/article/09f02e1e4b0345778a01dd34095da235
Publikováno v:
The Journal of Molecular Diagnostics. 25:121-131
Sarcomas are a diverse group of tumors, with greater than 70 subtypes in the current World Health Organization classification, each with distinct biological behavior requiring specific clinical management. A significant proportion of sarcomas are mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aef1d2e7240599accf3bd1168328cd3
https://doi.org/10.1016/j.jmoldx.2022.11.004
https://doi.org/10.1016/j.jmoldx.2022.11.004
Autor:
Amanda R. Dancsok, Dongxia Gao, Anna F. Lee, Sonja Eriksson Steigen, Jean-Yves Blay, David M. Thomas, Robert G. Maki, Torsten O. Nielsen, Elizabeth G. Demicco
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Early trials for immune checkpoint inhibitors in sarcomas have delivered mixed results, and efforts to improve outcomes now look to combinatorial strategies with novel immunotherapeutics, including some that target macrophages. To enhance our underst
Externí odkaz:
https://doaj.org/article/9e799c27028b46f5812c8bcc54b10c57
Autor:
Obi L. Griffith, Nicholas C. Spies, Meenakshi Anurag, Malachi Griffith, Jingqin Luo, Dongsheng Tu, Belinda Yeo, Jason Kunisaki, Christopher A Miller, Kilannin Krysiak, Jasreet Hundal, Benjamin J Ainscough, Zachary L. Skidmore, Katie Campbell, Runjun Kumar, Catrina Fronick, Lisa Cook, Jacqueline E. Snider, Sherri Davies, Shyam M. Kavuri, Eric C. Chang, Vincent Magrini, David E. Larson, Robert S Fulton, Shuzhen Liu, Samuel Leung, David Voduc, Ron Bose, Mitch Dowsett, Richard K. Wilson, Torsten O. Nielsen, Elaine R Mardis, Matthew J. Ellis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Unravelling the link between somatic mutation and prognosis in estrogen positive (ER+) breast cancer requires the use of long-term follow-up data. Here, combining archival formalin-fixed paraffin embedded tissue and targeted sequencing in three cohor
Externí odkaz:
https://doaj.org/article/fe27abc720eb4d50bc7f128d4b6ad490
Autor:
Maj-Britt Jensen, Anne-Vibeke Lænkholm, Torsten O. Nielsen, Jens Ole Eriksen, Pernille Wehn, Tressa Hood, Namratha Ram, Wesley Buckingham, Sean Ferree, Bent Ejlertsen
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-10 (2018)
Abstract Background The PAM50-based (Prosigna) risk of recurrence (ROR) score and intrinsic subtypes are prognostic for women with high-risk breast cancer. We investigate the predictive ability of Prosigna regarding the effectiveness of cyclophospham
Externí odkaz:
https://doaj.org/article/4673ff5f6aca4466993ba61ac60353e3