Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Torsten Minuth"'
Publikováno v:
European Journal of Organic Chemistry. 2008:5936-5945
In the given manuscript we summarize our activities to develop a scalable synthesis for a PEGylated peptide, which undergoes development for metabolic disorders. The polypeptide contains a sequence of 31 natural amino acids and carries a site-specifi
Autor:
Torsten Minuth, Heiner Apeler, Matthias Schramm, Klaus Dembowsky, Elke Stahl, Johannes-Peter Stasch, Henning Schröder, Wolfram Steinke, Frank Wunder, Peter Schmidt, Elisabeth Perzborn, Werner Schroeder, Cristina Alonso-Alija, Michael Haerter, Markus Heil, Ulrich Pleiss
Publikováno v:
British Journal of Pharmacology. 136:773-783
1. Soluble guanylyl cyclase (sGC) is the only proven receptor for the ubiquitous biological messenger nitric oxide (NO) and is intimately involved in many signal transduction pathways, most notably in regulating vascular tone and platelet function. s
Autor:
Matthias Schramm, Johannes-Peter Stasch, Cristina Alonso-Alija, Elisabeth Perzborn, Achim Feurer, Klaus Dembowsky, Heiner Apeler, Torsten Minuth, Alexander Straub
Publikováno v:
British Journal of Pharmacology. 135:333-343
BAY 41-8543 is a novel, highly specific and so far the most potent NO-independent stimulator of sGC. Here we report the effects of BAY 41-8543 on the isolated enzyme, endothelial cells, platelets, isolated vessels and Langendorff heart preparation. B
Autor:
Wolfram Steinke, Heiner Apeler, Klaus Dembowsky, Henning Schröder, Matthias Schramm, Eva Maria Becker, Johannes-Peter Stasch, Werner Schroeder, Elisabeth Perzborn, Cristina Alonso-Alija, Achim Feurer, Torsten Minuth, Elke Stahl, Rupert Gerzer, Alexander Straub, Ulrich Pleiß
Publikováno v:
Nature. 410:212-215
Nitric oxide (NO) is a widespread, potent, biological mediator that has many physiological and pathophysiological roles. Research in the field of NO appears to have followed a straightforward path, and the findings have been progressive: NO and cycli
Publikováno v:
Enzyme and Microbial Technology. 15:950-958
A novel oxidoreductase catalyzing the NADH-dependent reduction of a variety of carbonyl compounds, especially keto esters, was found in Candida parapsilosis DSM 70125. The enzyme was purified by fractional poly(ethylene glycol) precipitation, anion e
Autor:
Marita Grothus, Lothar Elling, Hans-Peter Brockamp, Maria-Regina Kula, Alois Steigel, Torsten Minuth, Jörg Peters
Publikováno v:
Tetrahedron: Asymmetry. 4:1173-1182
The chemoenzymatic synthesis of 20-6-deoxy-α-L-sorbofuranosyl-D-glucuse has been performed by coupling four enzymatic and one simple chemical step on a preparative scale with 17% overall yield. At first, pyruvic aldehyde dimethyl acetal was reduced
Publikováno v:
Biocatalysis. 8:31-46
The novel carbonyl reductase from Candida parapsilosis (CPCR) exhibits a very broad substrate specificity, accepting primary and secondary alcohols, aldehydes, ketoacetals, aliphatic and aromatic ketones, cyclic ketones, diketones, halogenated ketone
Publikováno v:
ChemInform. 24
Synthetic applications of the novel carbonyl reductases isolated from Candida parapsilosis and Rhodococcus erythropolis are reported. A number of different carbonyl compounds such as 3-, 4- and 5-ketoesters, ethyl 4-chloro 3-oxobutanoate, pyruvic ald
Autor:
Maria-Regina Kula, M. Grothus, Lothar Elling, Torsten Minuth, H.‐P. Brockamp, Jörg Peters, Alois Steigel
Publikováno v:
ChemInform. 24
Autor:
D. Paulsen, Helga Rübsamen-Waigmann, Uwe Langer, Torsten Minuth, Heiner Apeler, H. J. Henzler, Hans-Dietrich Horlein, Michael Pohlscheidt, Udo Reichl, Berthold Bödeker
Publikováno v:
Vaccine. 26(12)
For the production of a chemically inactivated Parapoxvirus ovis (PPVO), an adherent bovine kidney cell line was cultivated on Cytodex-3 microcarriers in suspension culture. The inactivated and purified virus particles have shown immune modulatory ac