Hypochlorhydria reduces mortality in heart failure caused by Kcne2 gene deletion

Autor: Geoffrey W. Abbott, Torsten K. Roepke, Rían W. Manville, Clemens Köhncke, Angele De Silva, Bettina Purfürst, Ulrike Lisewski, Leonhard Schleussner, Soo Min Lee

Publikováno v: FASEB J

Heart failure (HF) is an increasing global health crisis, affecting 40 million people and causing 50% mortality within 5 years of diagnosis. A fuller understanding of the genetic and environmental factors underlying HF, and novel therapeutic approach

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a79a73cad6a27f6857e8f20c216ab8
https://doi.org/10.1096/fj.202000013rr

Deletion in mice of X‐linked, Brugada syndrome–and atrial fibrillation–associated Kcne5 augments ventricular K v currents and predisposes to ventricular arrhythmia

Autor: Geoffrey W. Abbott, Jens-Peter David, Torsten K. Roepke, Nicola Wilck, Janine Lossie, Thomas A. Jepps, Shawn M. Crump, Elke Bocksteins, Nicole Schmitt, Ulrike Lisewski

Publikováno v: The FASEB journal

KCNE5 is an X-linked gene encoding KCNE5, an ancillary subunit to voltage-gated potassium (K-V) channels. Human KCNE5 mutations are associated with atrial fibrillation (AF)- and Brugada syndrome (BrS)-induced cardiac arrhythmias that can arise from i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120b0f249a0e03daea226735e2780269
https://doi.org/10.1096/fj.201800502r

Diagnosis and treatment of cardiac echinococcosis

Autor: Robert Rainer Flieger, Kadir Yilmaz, Torsten K. Roepke, Sascha Kahlfuß

Publikováno v: Heart. 102:1348-1353

Cardiac echinococcosis is a rare manifestation of cystic echinococcosis (CE) caused by the tapeworm Echinococcus granulosus Among all patients suffering from CE, only 0.5%-2% exhibit a cardiac involvement. In addition, during the past years the numbe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d459cadfa04eded067a1e1f72f7cf9cf
https://doi.org/10.1136/heartjnl-2016-309350

Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular K

Autor: Jens-Peter, David, Ulrike, Lisewski, Shawn M, Crump, Thomas A, Jepps, Elke, Bocksteins, Nicola, Wilck, Janine, Lossie, Torsten K, Roepke, Nicole, Schmitt, Geoffrey W, Abbott

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(2)

KCNE5 is an X-linked gene encoding KCNE5, an ancillary subunit to voltage-gated potassium (K(V)) channels. Human KCNE5 mutations are associated with atrial fibrillation (AF)– and Brugada syndrome (BrS)–induced cardiac arrhythmias that can arise f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1bac45a0b1d46b17f4b03f3c0b2a641d
https://pubmed.ncbi.nlm.nih.gov/30289750

Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia

Autor: Torsten K. Roepke, Clemens Köhncke, Ulrike Lisewski, Dara Nguyen, Zhaoyang Hu, Marie Anand, Ritu Kant, Soo Min Lee, Geoffrey W. Abbott

Publikováno v: Lee, SM; Nguyen, D; Anand, M; Kant, R; Koehncke, C; Lisewski, U; et al.(2016). Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia. SCIENTIFIC REPORTS, 6. doi: 10.1038/srep23118. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/98s5z494
Scientific Reports
Scientific reports, vol 6, iss 1

Nonalcoholic fatty liver disease (NAFLD) is an increasing health problem worldwide, with genetic, epigenetic and environmental components. Here, we describe the first example of NAFLD caused by genetic disruption of a mammalian potassium channel subu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f0e96535b6029ad0a8c002f67b1b85
http://www.escholarship.org/uc/item/98s5z494