Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Torsten Dunkern"'
Autor:
Alice Krebs, Tanja Waldmann, Martin F. Wilks, Barbara M. A. van Vugt-Lussenburg, Bart van der Burg, Andrea Terron, Thomas Steger-Hartmann, Joelle Ruegg, Costanza Rovida, Emma Pedersen, Giorgia Pallocca, Mirjam Luijten, Sofia B. Leite, Stefan Kustermann, Hennicke Kamp, Julia Hoeng, Philip Hewitt, Matthias Herzler, Jan G. Hengstler, Tuula Heinonen, Thomas Hartung, Barry Hardy, Florian Gantner, Ellen Fritsche, Kristina Fant, Janine Ezendam, Thomas Exner, Torsten Dunkern, Daniel R. Dietrich, Sandra Coecke, Francois Busquet, Albert Braeuning, Olesja Bondarenko, Susanne H. Bennekou, Mario Beilmann, Marcel Leist
Publikováno v:
ALTEX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb6c6416ad6a2de566c400479e5f185
Autor:
Mahindra Makhija, Heike Goebel, Edith Rolser, Torsten Dunkern, Waltraud Burckhard-Boer, Prashant S. Kharkar, Arati Prabhu, Premkumar Arumugam
Publikováno v:
Journal of Computer-Aided Molecular Design. 26:1277-1292
IMPDH (Inosine 5'-monophosphate dehydrogenase) catalyzes a rate-limiting step in the de novo biosynthesis of guanine nucleotides. IMPDH inhibition in sensitive cell types (e.g., lymphocytes) blocks proliferation (by blocking RNA and DNA synthesis as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffa8a5b62455d534b0438dac58a531c
https://doi.org/10.1007/s10822-012-9615-5
https://doi.org/10.1007/s10822-012-9615-5
Publikováno v:
Neurochemistry International. 59:837-846
Inflammation is an important hallmark of all neurodegenerative diseases and activation of different glial populations may be involved in the progression of some of these disorders. Especially, the activation of astroglia can lead to long-term detrime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aebf630d69e0c891548c396bf10edb76
https://doi.org/10.1016/j.neuint.2011.08.012
https://doi.org/10.1016/j.neuint.2011.08.012
Publikováno v:
Journal of Cellular Physiology. 226:1970-1980
Lung fibroblast proliferation and differentiation into myofibroblasts are pathological key events during development of lung fibrosis. Cyclic nucleotide signaling is described as a negative modulator of these cellular processes, and cyclic nucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4f467e323993a3c7b4100ec6654382
https://doi.org/10.1002/jcp.22529
https://doi.org/10.1002/jcp.22529
Publikováno v:
Handbook of experimental pharmacology. (204)
Classic PDE5 inhibitors interact with and block the catalytic site of PDE5. They have been clinically validated for treatment of erectile dysfunction as well as reduction of pulmonary arterial pressure, improvement of exercise capacity, quality of li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9599eb53e6f9e559f834110dfe2e8fb7
https://pubmed.ncbi.nlm.nih.gov/21695639
https://pubmed.ncbi.nlm.nih.gov/21695639
Publikováno v:
Phosphodiesterases as Drug Targets ISBN: 9783642179686
Classic PDE5 inhibitors interact with and block the catalytic site of PDE5. They have been clinically validated for treatment of erectile dysfunction as well as reduction of pulmonary arterial pressure, improvement of exercise capacity, quality of li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd02d702339e0c40ef0c5f04ccf5d6e4
https://doi.org/10.1007/978-3-642-17969-3_6
https://doi.org/10.1007/978-3-642-17969-3_6
Publikováno v:
Journal of cellular physiology. 223(2)
Interleukin-1β (IL-1β) and basic fibroblast growth factor (bFGF) are important regulators of proliferation, and their expression is increased in lungs of patients with asthma, idiopathic pulmonary fibrosis (IPF), or chronic obstructive pulmonary di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f870463f3ba00e07e9c691103dacee
https://pubmed.ncbi.nlm.nih.gov/20082309
https://pubmed.ncbi.nlm.nih.gov/20082309
Autor:
Torsten Dunkern, Peter Deibert, Rene Schmidt, Leonie Halverscheid, Benedikt H. J. Pannen, Hubert E. Blum, Wolfgang Kreisel
Publikováno v:
BMC Gastroenterology, Vol 9, Iss 1, p 69 (2009)
BMC Gastroenterology
BMC Gastroenterology
Background The NO - cGMP system plays a key role in the regulation of sinusoidal tonus and liver blood flow with phosphodiesterase-5 (PDE-5) terminating the dilatory action of cGMP. We, therefore, investigated the effects of PDE-5 inhibitors on hepat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883f5194bffb6ddfefe90bec298de810
http://www.biomedcentral.com/1471-230X/9/69
http://www.biomedcentral.com/1471-230X/9/69
Autor:
Werner Seeger, Robert Voswinckel, Christina Kaulen, Renate Paddenberg, Friedrich Grimminger, Hossein Ardeschir Ghofrani, Norbert Weissmann, Christian Schudt, Walter Klepetko, Torsten Dunkern, Arun Samidurai, Xia Tian, Soni Savai Pullamsetti, Wolfgang Kummer, Rio Dumitrascu, Jiang Zhou, Ralph T. Schermuly, Grazyna Kwapiszewska
Publikováno v:
Circulation. 115(17)
Background— Pulmonary arterial hypertension (PAH) is a life-threatening disease, characterized by vascular smooth muscle cell hyperproliferation. The calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) may play a major role in vascular smooth m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc5aadb6fa8a3afd05d92dd31a0d27f
https://pubmed.ncbi.nlm.nih.gov/17438150
https://pubmed.ncbi.nlm.nih.gov/17438150
Publikováno v:
International journal of molecular medicine. 10(4)
Ras-homologous GTPases are involved in the regulation of genotoxic stress-induced gene expression and cell death. Since they need C-terminal isoprenylation for correct intracellular localization and function, we investigated whether depletion of cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df0ca120d415384d56337ee1c14ab620
https://pubmed.ncbi.nlm.nih.gov/12239596
https://pubmed.ncbi.nlm.nih.gov/12239596