Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Torsten Herbertz"'
Autor:
Maureen Caligiuri, Grace L. Williams, Jennifer Castro, Linda Battalagine, Erik Wilker, Lili Yao, Shawn Schiller, Angela Toms, Ping Li, Eneida Pardo, Bradford Graves, Joey Azofeifa, Agustin Chicas, Torsten Herbertz, Maria Lai, Joel Basken, Kenneth W. Wood, Qunli Xu, Sylvie M. Guichard
Publikováno v:
Targeted Oncology. 18:269-285
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b83a4b5ffa700d6591f630c62f30ad00
https://doi.org/10.1007/s11523-023-00949-7
https://doi.org/10.1007/s11523-023-00949-7
Autor:
Bruce Follows, Shawn Fessler, Timm Baumeister, Ann-Marie Campbell, Mary Margaret Zablocki, Hongbin Li, Deepali Gotur, Zhongguo Wang, Xiaozhang Zheng, Lisa Molz, Cokey Nguyen, Torsten Herbertz, Liann Wang, Kenneth Bair
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2375-2382
Mcl-1 is an anti-apoptotic protein overexpressed in hematological malignancies and several human solid tumors. Small molecule inhibition of Mcl-1 would offer an effective therapy to Mcl-1 mediated resistance. Subsequently, it has been the target of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c397dc7a19ede1383733b944a5d0534
https://doi.org/10.1016/j.bmcl.2019.06.008
https://doi.org/10.1016/j.bmcl.2019.06.008
Autor:
Grace L. Williams, Shawn Schiller, Monica A. Alvarez Morales, Crystal McKinnon, Matthew W. Martin, George P. Luke, Torsten Herbertz, Adam C. Talbot, Stephen Hubbs, Katherine J. Kayser-Bricker, Daniel Cardillo, Paul Troccolo, David S. Millan, Rachel L. Mendes
Publikováno v:
ACS Medicinal Chemistry Letters. 8:847-852
A protein structure-guided drug design approach was employed to develop small molecule inhibitors of the BET family of bromodomains that were distinct from the known (+)-JQ1 scaffold class. These efforts led to the identification of a series of subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe1ba6e7a6d542c07f4daef01ede3b1
https://doi.org/10.1021/acsmedchemlett.7b00191
https://doi.org/10.1021/acsmedchemlett.7b00191
Publikováno v:
ACS Chemical Neuroscience
The central nervous system (CNS) is the major area that is affected by aging. Alzheimer's disease (AD), Parkinson's disease (PD), brain cancer, and stroke are the CNS diseases that will cost trillions of dollars for their treatment. Achievement of ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9082302be26311a31e107b9e1fc8d1ef
https://doi.org/10.1021/cn200100h
https://doi.org/10.1021/cn200100h
Autor:
Randy W. Jackson, Matthew G. LaPorte, Torsten Herbertz, Tandy L. Draper, Janet A. Gaboury, Susan R. Rippin, Ravi Patel, Srinivas K. Chunduru, Christopher A. Benetatos, Dorothy C. Young, Christopher J. Burns, Stephen M. Condon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3227-3231
We describe the structure-activity relationship of the C7-position of pyrano[3,4-b]indole-based inhibitors of HCV NS5B polymerase. Further exploration of the allosteric binding site led to the discovery of the significantly more potent compounds 13 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e503ff3f12bbc5a882c291bc31ea1567
https://doi.org/10.1016/j.bmcl.2011.04.052
https://doi.org/10.1016/j.bmcl.2011.04.052
Autor:
Deborah Galinis, Sheila J. Miknyoczki, Ted L. Underiner, Damaris Rolon-Steele, Jean Husten, Craig A. Zificsak, Thelma S. Angeles, Torsten Herbertz, Mark S. Albom, Bruce D. Dorsey, Laura S. Kocsis, Kevin J. Wells-Knecht, Jay P. Theroff, Lisa D. Aimone, Kelli S. Zeigler, Candace S. Worrell, Rebecca A. Brown, Christine LoSardo, Seetha Murthy, Jennifer Grobelny
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:660-663
Elaboration of the SAR around a series of 2,4-diaminopyrimidines led to a number of c-Met inhibitors in which kinase selectivity was modulated by substituents appended on the C4-aminobenzamide ring and the nature of the C2-aminoaryl ring. Further lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2f5ede7c3bb696001314f924df06f4
https://doi.org/10.1016/j.bmcl.2010.12.013
https://doi.org/10.1016/j.bmcl.2010.12.013
Autor:
Eugene C. Amparo, Srinivas K. Chunduru, Ariamala Gopalsamy, Christopher A. Benetatos, Lori E. Miller, Tandy L. Draper, Christopher J. Burns, Matthew G. LaPorte, Lara K. Leister, Torsten Herbertz, Dorothy C. Young, Stephen M. Condon, Blackledge Charles W, Gerry Rhodes, Alison R. Hussey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2968-2973
We describe the structure-activity relationship of the C1-group of pyrano[3,4-b]indole based inhibitors of HCV NS5B polymerase. Further exploration of the allosteric binding site led to the discovery of the significantly more potent compound 12.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82b0bf920d396980908e52cb23485ed
https://doi.org/10.1016/j.bmcl.2010.03.002
https://doi.org/10.1016/j.bmcl.2010.03.002
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 10:7-27
The scatter factor/hepatocyte growth factor (HGF)-c-Met axis is involved in the malignant phenotype of various tumor types via activation of a wide range of autocrine and paracrine processes. Autocrine activation of tumor cell c-Met receptors enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a06afc09f2777a1329ec565f923b48a
https://doi.org/10.2174/1871520611009010007
https://doi.org/10.2174/1871520611009010007
Autor:
Daniel C. Pevear, Dorothy C. Young, Christopher A. Benetatos, Glen A. Coburn, Susan R. Rippin, Christopher J. Burns, Marc S. Collett, Christopher J. Rizzo, Joel S. Christensen, Tandy L. Draper, Tiejun Gao, John O'Connell, Stephen M. Condon, Kristin Galie, Alison R. Hussey, Srinivas K. Chunduru, Gerry Rhodes, Norman M. Kneteman, Janet A. Gaboury, Tarek S. Mansour, Randy W. Jackson, D. Lorne Tyrrell, Anita Y. M. Howe, Matthew G. LaPorte, Torsten Herbertz
Publikováno v:
ChemMedChem. 3:1508-1515
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb243ee1bca7db08b1f5ebe75da0f35
https://doi.org/10.1002/cmdc.200800168
https://doi.org/10.1002/cmdc.200800168
Publikováno v:
Journal of Medicinal Chemistry. 51:5149-5171
toward kinase inhibitor discovery, with the result that several kinase inhibitors have been approved as drugs since 2001. The commercial success of imatinib (N-(4-methyl-3-(4-(pyridin-3yl)pyrimidin-2-ylamino)phenyl)-4-((4-methylpiperazin-1-l)methyl)b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cfdacb02a80ba9f72c931b97abe0190
https://doi.org/10.1021/jm800475y
https://doi.org/10.1021/jm800475y