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Activation of recombinases at specific DNA loci by zinc-finger domain insertions.

Autor: Mukhametzyanova L; Medical Systems Biology, Medical Faculty, Technical University Dresden, Dresden, Germany., Schmitt LT; Medical Systems Biology, Medical Faculty, Technical University Dresden, Dresden, Germany.; Seamless Therapeutics GmbH, Dresden, Germany., Torres-Rivera J; Medical Systems Biology, Medical Faculty, Technical University Dresden, Dresden, Germany., Rojo-Romanos T; Medical Systems Biology, Medical Faculty, Technical University Dresden, Dresden, Germany.; Seamless Therapeutics GmbH, Dresden, Germany., Lansing F; Medical Systems Biology, Medical Faculty, Technical University Dresden, Dresden, Germany.; Seamless Therapeutics GmbH, Dresden, Germany., Paszkowski-Rogacz M; Medical Systems Biology, Medical Faculty, Technical University Dresden, Dresden, Germany., Hollak H; Medical Systems Biology, Medical Faculty, Technical University Dresden, Dresden, Germany.; Seamless Therapeutics GmbH, Dresden, Germany., Brux M; Medical Systems Biology, Medical Faculty, Technical University Dresden, Dresden, Germany., Augsburg M; Medical Systems Biology, Medical Faculty, Technical University Dresden, Dresden, Germany., Schneider PM; Medical Systems Biology, Medical Faculty, Technical University Dresden, Dresden, Germany.; Seamless Therapeutics GmbH, Dresden, Germany., Buchholz F; Medical Systems Biology, Medical Faculty, Technical University Dresden, Dresden, Germany. frank.buchholz@tu-dresden.de.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2024 Dec; Vol. 42 (12), pp. 1844-1854. Date of Electronic Publication: 2024 Jan 31.