Efficacy and safety of a structured de-escalation from antipseudomonal β-lactams in bloodstream infections due to Enterobacterales (SIMPLIFY): an open-label, multicentre, randomised trial

Autor: De Cueto, Marina, Borreguero, Irene, Nieto Aranda, Javier, Sousa Domínguez, Adrián, González-Rico, Claudia, Fariñas, María Carmen, Fernández Ávila, María Luisa, Romero Palacios, Alberto, Guerrero Sánchez, Francisca María, Rúa Gómez, Marta, Bilbao del Olmo, Idoia, Calbo, Esther, Dietl, Beatriz, Ibarguren Pinilla, Maialen, Gómez-Ruiz de Arbulo, Marta, Torres Beceiro, Isabel, Machuca, Isabel, Cano, Ángela, Giner Oncina, Livia, Pinargote Celorio, Héctor, Cendejas, Emilio, Romero Gómez, María, Argüelles Curto, Adrián, Reguero, José María, Díaz-López, María Dolores, Paño, José Ramón, López-Cortés, Luis Eduardo ^*, Delgado-Valverde, Mercedes, Moreno-Mellado, Elisa, Goikoetxea Aguirre, Josune, Guio Carrión, Laura, Blanco Vidal, María José, López Soria, Leyre Mónica, Pérez-Rodríguez, María Teresa, Martínez Lamas, Lucía, Arnaiz de las Revillas, Francisco, Armiñanzas, Carlos, Ruiz de Alegría-Puig, Carlos, Jiménez Aguilar, Patricia, del Carmen Martínez-Rubio, María, Sáez-Bejar, Carmen, de las Cuevas, Carmen, Martín-Aspas, Andrés, Galán, Fátima, Yuste, José Ramón, Leiva-León, José, Bou, Germán, Capón González, Patricia, Boix-Palop, Lucía, Xercavins-Valls, Mariona, Goenaga-Sánchez, Miguel Ángel, Anza, Diego Vicente, Castón, Juan José, Rufián, Manuel Recio, Merino, Esperanza, Rodríguez, Juan Carlos, Loeches, Belén, Cuervo, Guillermo, Guerra Laso, José Manuel, Plata, Antonio, Pérez Cortés, Salvador, López Mato, Pablo, Sierra Monzón, José Luis, Rosso-Fernández, Clara, Bravo-Ferrer, José María, Retamar-Gentil, Pilar, Rodríguez-Baño, Jesús

Publikováno v: In The Lancet Infectious Diseases April 2024 24(4):375-385

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Dispersal history of SARS-CoV-2 in Galicia, Spain.

Autor: Gallego-García P; CINBIO, Universidade de Vigo, 36310 Vigo, Spain.; Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO., Estévez-Gómez N; CINBIO, Universidade de Vigo, 36310 Vigo, Spain.; Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO., De Chiara L; CINBIO, Universidade de Vigo, 36310 Vigo, Spain.; Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO.; Department of Biochemistry, Genetics, and Immunology, Universidade de Vigo, Vigo 36310, Spain., Alvariño P; CINBIO, Universidade de Vigo, 36310 Vigo, Spain., Juiz-González PM; Servicio de Microbiología del Complejo Hospitalario Universitario de Ferrol, 15405 Ferrol., Torres-Beceiro I; Servicio de Microbiología del Complejo Hospitalario Universitario de Ferrol, 15405 Ferrol., Poza M; Microbiology Research Group, Institute of Biomedical Research (INIBIC) - Interdisciplinary Center for Chemistry and Biology (CICA) - University of A Coruña (UDC) - CIBER de Enfermedades Infecciosas (CIBERINFEC-ISCIII), Madrid. Servicio de Microbiología, 3° planta, Edificio Sur, Hospital Universitario A Coruña, As Xubias, 15006, A Coruña, Spain.; Microbiome and Health Group, Faculty of Sciences, University of A Coruña (UDC). Campus da Zapateira, 15008, A Coruña, Spain., Vallejo JA; Microbiology Research Group, Institute of Biomedical Research (INIBIC) - Interdisciplinary Center for Chemistry and Biology (CICA) - University of A Coruña (UDC) - CIBER de Enfermedades Infecciosas (CIBERINFEC-ISCIII), Madrid. Servicio de Microbiología, 3° planta, Edificio Sur, Hospital Universitario A Coruña, As Xubias, 15006, A Coruña, Spain., Rumbo-Feal S; Microbiology Research Group, Institute of Biomedical Research (INIBIC) - Interdisciplinary Center for Chemistry and Biology (CICA) - University of A Coruña (UDC) - CIBER de Enfermedades Infecciosas (CIBERINFEC-ISCIII), Madrid. Servicio de Microbiología, 3° planta, Edificio Sur, Hospital Universitario A Coruña, As Xubias, 15006, A Coruña, Spain., Conde-Pérez K; Microbiology Research Group, Institute of Biomedical Research (INIBIC) - Interdisciplinary Center for Chemistry and Biology (CICA) - University of A Coruña (UDC) - CIBER de Enfermedades Infecciosas (CIBERINFEC-ISCIII), Madrid. Servicio de Microbiología, 3° planta, Edificio Sur, Hospital Universitario A Coruña, As Xubias, 15006, A Coruña, Spain., Aja-Macaya P; Microbiology Research Group, Institute of Biomedical Research (INIBIC) - Interdisciplinary Center for Chemistry and Biology (CICA) - University of A Coruña (UDC) - CIBER de Enfermedades Infecciosas (CIBERINFEC-ISCIII), Madrid. Servicio de Microbiología, 3° planta, Edificio Sur, Hospital Universitario A Coruña, As Xubias, 15006, A Coruña, Spain., Ladra S; Database Laboratory, Research Center for Information and Communication Technologies (CITIC), University of A Coruña (UDC), Campus de Elviña, 15071 A Coruña, Spain., Moreno-Flores A; Servicio de Microbiología, Hospital Universitario Lucus Augusti, Lugo, Spain., Gude-González MJ; Servicio de Microbiología, Hospital Universitario Lucus Augusti, Lugo, Spain., Coira A; Microbiology Department, Complexo Hospitalario Universitario de Santiago de Compostela. SERGAS - Microbiology Research Group, Institute of Biomedical Research (IDIS) - Santiago de Compostela 15706, Spain., Aguilera A; Microbiology Department, Complexo Hospitalario Universitario de Santiago de Compostela. SERGAS - Microbiology Research Group, Institute of Biomedical Research (IDIS) - Santiago de Compostela 15706, Spain., Costa-Alcalde JJ; Microbiology Department, Complexo Hospitalario Universitario de Santiago de Compostela. SERGAS - Microbiology Research Group, Institute of Biomedical Research (IDIS) - Santiago de Compostela 15706, Spain., Trastoy R; Microbiology Department, Complexo Hospitalario Universitario de Santiago de Compostela. SERGAS - Microbiology Research Group, Institute of Biomedical Research (IDIS) - Santiago de Compostela 15706, Spain., Barbeito-Castiñeiras G; Microbiology Department, Complexo Hospitalario Universitario de Santiago de Compostela. SERGAS - Microbiology Research Group, Institute of Biomedical Research (IDIS) - Santiago de Compostela 15706, Spain., García-Souto D; CiMUS, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain. - Department of Zoology, Genetics and Physic Anthropology, 15782, Santiago de Compostela, Spain., Tubio JMC; CiMUS, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain. - Department of Zoology, Genetics and Physic Anthropology, 15782, Santiago de Compostela, Spain., Trigo-Daporta M; Clinical Microbiology Unit, Complexo Hospitalario Universitario de Pontevedra, Pontevedra, Spain., Camacho-Zamora P; Clinical Microbiology Unit, Complexo Hospitalario Universitario de Pontevedra, Pontevedra, Spain., Costa JG; Servicio de Microbiología. Complejo Hospitalario Universitario de Ourense, 32005, Ourense, Spain., González-Domínguez M; Servicio de Microbiología. Complejo Hospitalario Universitario de Ourense, 32005, Ourense, Spain., Canoura-Fernández L; Servicio de Microbiología. Complejo Hospitalario Universitario de Ourense, 32005, Ourense, Spain., Glez-Peña D; CINBIO, Universidade de Vigo, 36310 Vigo, Spain.; Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO., Pérez-Castro S; Microbiology Department, Complexo Hospitalario Universitario de Vigo (CHUVI), SERGAS, Vigo 36213, Spain.; Microbiology and Infectology Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain., Cabrera JJ; Microbiology Department, Complexo Hospitalario Universitario de Vigo (CHUVI), SERGAS, Vigo 36213, Spain.; Microbiology and Infectology Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain., Daviña-Núñez C; Microbiology and Infectology Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain., Godoy-Diz M; Microbiology Department, Complexo Hospitalario Universitario de Vigo (CHUVI), SERGAS, Vigo 36213, Spain., Treinta-Álvarez AB; Microbiology Department, Complexo Hospitalario Universitario de Vigo (CHUVI), SERGAS, Vigo 36213, Spain., Veiga MI; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal - ICVS/3B's-PT Government Associate Laboratory, 4806-909, Guimarães/ Braga, Portugal., Sousa JC; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal - ICVS/3B's-PT Government Associate Laboratory, 4806-909, Guimarães/ Braga, Portugal., Osório NS; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal - ICVS/3B's-PT Government Associate Laboratory, 4806-909, Guimarães/ Braga, Portugal., Comas I; Tuberculosis Genomics Unit, Biomedicine Institute of Valencia, Spanish Research Council (CSIC), Valencia, Spain.; CIBER in Epidemiology and Public Health, Spain; Joint Research Unit 'Infection and Public Health' FISABIO-University of Valencia, Valencia, Spain., González-Candelas F; CIBER in Epidemiology and Public Health, Spain; Joint Research Unit 'Infection and Public Health' FISABIO-University of Valencia, Valencia, Spain.; Institute for Integrative Systems Biology (I2SysBio), University of Valencia-CSIC, Valencia, Spain., Hong SL; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Clinical and Epidemiological Virology, KU Leuven - University of Leuven, 3000 Leuven, Belgium., Bollen N; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Clinical and Epidemiological Virology, KU Leuven - University of Leuven, 3000 Leuven, Belgium., Dellicour S; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Clinical and Epidemiological Virology, KU Leuven - University of Leuven, 3000 Leuven, Belgium.; Spatial Epidemiology Lab, Université Libre de Bruxelles, 1000 Brussels, Belgium., Baele G; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Clinical and Epidemiological Virology, KU Leuven - University of Leuven, 3000 Leuven, Belgium., Suchard MA; Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA - Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA - Department of Computational Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA., Lemey P; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Clinical and Epidemiological Virology, KU Leuven - University of Leuven, 3000 Leuven, Belgium.; Global Virus Network (GVN), Baltimore, MD 21201, USA., Agulla A; Servicio de Microbiología del Complejo Hospitalario Universitario de Ferrol, 15405 Ferrol., Bou G; Microbiology Research Group, Institute of Biomedical Research (INIBIC) - Interdisciplinary Center for Chemistry and Biology (CICA) - University of A Coruña (UDC) - CIBER de Enfermedades Infecciosas (CIBERINFEC-ISCIII), Madrid. Servicio de Microbiología, 3° planta, Edificio Sur, Hospital Universitario A Coruña, As Xubias, 15006, A Coruña, Spain., Alonso-García P; Servicio de Microbiología, Hospital Universitario Lucus Augusti, Lugo, Spain., Pérez-Del-Molino ML; Microbiology Department, Complexo Hospitalario Universitario de Santiago de Compostela. SERGAS - Microbiology Research Group, Institute of Biomedical Research (IDIS) - Santiago de Compostela 15706, Spain., García-Campello M; Clinical Microbiology Unit, Complexo Hospitalario Universitario de Pontevedra, Pontevedra, Spain., Paz-Vidal I; Servicio de Microbiología. Complejo Hospitalario Universitario de Ourense, 32005, Ourense, Spain., Regueiro B; Microbiology Department, Complexo Hospitalario Universitario de Vigo (CHUVI), SERGAS, Vigo 36213, Spain.; Microbiology and Infectology Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain., Posada D; CINBIO, Universidade de Vigo, 36310 Vigo, Spain.; Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO.; Department of Biochemistry, Genetics, and Immunology, Universidade de Vigo, Vigo 36310, Spain.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Feb 28. Date of Electronic Publication: 2024 Feb 28.