High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene

Autor: Torres-Arzayus MI, Font de Mora J, Yuan J, Vazquez F, Bronson R, Rue M, Sellers WR, Brown M

Publikováno v: Cancer Cell
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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The gene encoding AIB1, an estrogen receptor coactivator, is amplified in a subset of human breast cancers. Here we show that overexpression of AIB1 in transgenic mice (AIB1-tg) leads to mammary hypertrophy, hyperplasia, abnormal postweaning involuti

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Ret inhibition decreases growth and metastatic potential of estrogen receptor positive breast cancer cells.

Autor: Gattelli A; Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland., Nalvarte I, Boulay A, Roloff TC, Schreiber M, Carragher N, Macleod KK, Schlederer M, Lienhard S, Kenner L, Torres-Arzayus MI, Hynes NE

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2013 Sep; Vol. 5 (9), pp. 1335-50. Date of Electronic Publication: 2013 Jul 19.

CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization.

Autor: Yang XH; Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA., Richardson AL, Torres-Arzayus MI, Zhou P, Sharma C, Kazarov AR, Andzelm MM, Strominger JL, Brown M, Hemler ME

Publikováno v: Cancer research [Cancer Res] 2008 May 01; Vol. 68 (9), pp. 3204-13.

A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer.

Autor: Eeckhoute J; Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Carroll JS, Geistlinger TR, Torres-Arzayus MI, Brown M

Publikováno v: Genes & development [Genes Dev] 2006 Sep 15; Vol. 20 (18), pp. 2513-26.