Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Torrents de la Peña A"'
Autor:
Iván del Moral-Sánchez, Edmund G. Wee, Yuejiao Xian, Wen-Hsin Lee, Joel D. Allen, Alba Torrents de la Peña, Rebeca Fróes Rocha, James Ferguson, André N. León, Sylvie Koekkoek, Edith E. Schermer, Judith A. Burger, Sanjeev Kumar, Robby Zwolsman, Mitch Brinkkemper, Aafke Aartse, Dirk Eggink, Julianna Han, Meng Yuan, Max Crispin, Gabriel Ozorowski, Andrew B. Ward, Ian A. Wilson, Tomáš Hanke, Kwinten Sliepen, Rogier W. Sanders
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-18 (2024)
Abstract Recombinant native-like HIV-1 envelope glycoprotein (Env) trimers are used in candidate vaccines aimed at inducing broadly neutralizing antibodies. While state-of-the-art SOSIP or single-chain Env designs can be expressed as native-like trim
Externí odkaz:
https://doaj.org/article/9406da7e97304295838f177acd6e13b0
Autor:
Torrents de la Peña, Alba, Sewall, Leigh M., de Paiva Froes Rocha, Rebeca, Jackson, Abigail M., Pratap, Payal P., Bangaru, Sandhya, Cottrell, Christopher A., Mohanty, Subhasis, Shaw, Albert C., Ward, Andrew B.
Publikováno v:
In Cell Reports Methods 26 June 2023 3(6)
Autor:
Iván del Moral-Sánchez, Rebecca A. Russell, Edith E. Schermer, Christopher A. Cottrell, Joel D. Allen, Alba Torrents de la Peña, Celia C. LaBranche, Sanjeev Kumar, Max Crispin, Andrew B. Ward, David C. Montefiori, Quentin J. Sattentau, Kwinten Sliepen, Rogier W. Sanders
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-12 (2022)
Abstract Soluble HIV-1 envelope glycoprotein (Env) immunogens are a prime constituent of candidate vaccines designed to induce broadly neutralizing antibodies. Several lines of evidence suggest that enhancing Env immunogen thermostability can improve
Externí odkaz:
https://doaj.org/article/28104a39e7cf4428aa7d7f68001f96c6
Autor:
Jelle van Schooten, Anna Schorcht, Elinaz Farokhi, Jeffrey C Umotoy, Hongmei Gao, Tom L G M van den Kerkhof, Jessica Dorning, Tim G Rijkhold Meesters, Patricia van der Woude, Judith A Burger, Tom Bijl, Riham Ghalaiyini, Alba Torrents de la Peña, Hannah L Turner, Celia C Labranche, Robyn L Stanfield, Devin Sok, Hanneke Schuitemaker, David C Montefiori, Dennis R Burton, Gabriel Ozorowski, Michael S Seaman, Ian A Wilson, Rogier W Sanders, Andrew B Ward, Marit J van Gils
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010945 (2022)
Broadly neutralizing antibodies (bNAbs) have remarkable breadth and potency against most HIV-1 subtypes and are able to prevent HIV-1 infection in animal models. However, bNAbs are extremely difficult to induce by vaccination. Defining the developmen
Externí odkaz:
https://doaj.org/article/9a8650aeeb2e4e9db4484031f5c06256
Autor:
Aleksandar Antanasijevic, Leigh M. Sewall, Christopher A. Cottrell, Diane G. Carnathan, Luis E. Jimenez, Julia T. Ngo, Jennifer B. Silverman, Bettina Groschel, Erik Georgeson, Jinal Bhiman, Raiza Bastidas, Celia LaBranche, Joel D. Allen, Jeffrey Copps, Hailee R. Perrett, Kimmo Rantalainen, Fabien Cannac, Yuhe R. Yang, Alba Torrents de la Peña, Rebeca Froes Rocha, Zachary T. Berndsen, David Baker, Neil P. King, Rogier W. Sanders, John P. Moore, Shane Crotty, Max Crispin, David C. Montefiori, Dennis R. Burton, William R. Schief, Guido Silvestri, Andrew B. Ward
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Here, the authors present cryoEMPEM, a method for high-resolution structural analysis of vaccine-elicited polyclonal antibody responses. They apply cryoEMPEM in combination with standard serology experiments to characterize the polyclonal antibody (p
Externí odkaz:
https://doaj.org/article/04ab87746dbe4d4ea81ab039e453c3ac
Autor:
del Moral-Sánchez, Iván, Wee, Edmund G., Xian, Yuejiao, Lee, Wen-Hsin, Allen, Joel D., Torrents de la Peña, Alba, Fróes Rocha, Rebeca, Ferguson, James, León, André N., Koekkoek, Sylvie, Schermer, Edith E., Burger, Judith A., Kumar, Sanjeev, Zwolsman, Robby, Brinkkemper, Mitch, Aartse, Aafke, Eggink, Dirk, Han, Julianna, Yuan, Meng, Crispin, Max
Publikováno v:
NPJ Vaccines; 4/6/2024, Vol. 9 Issue 1, p1-18, 18p
Autor:
Tomris, Ilhan, van der Woude, Roosmarijn, de Paiva Froes Rocha, Rebeca, Torrents de la Peña, Alba, Ward, Andrew B., de Vries, Robert P.
Publikováno v:
Protein Science: A Publication of the Protein Society; Apr2024, Vol. 33 Issue 4, p1-13, 13p
Autor:
Torrents de la Peña, Alba1, Sliepen, Kwinten2,3 k.h.sliepen@amsterdamumc.nl, Eshun-Wilson, Lisa1, Newby, Maddy L.4, Allen, Joel D.4, Zon, Ian2,3, Koekkoek, Sylvie2,3, Chumbe, Ana2,3, Crispin, Max4, Schinkel, Janke2,3, Lander, Gabriel C.1, Sanders, Rogier W.2,3,5 r.w.sanders@amsterdamumc.nl, Ward, Andrew B.1 andrew@scripps.edu
Publikováno v:
Science. 10/21/2022, Vol. 378 Issue 6617, p263-269. 7p. 4 Color Photographs.
Autor:
Kwinten Sliepen, Byung Woo Han, Ilja Bontjer, Petra Mooij, Fernando Garces, Anna-Janina Behrens, Kimmo Rantalainen, Sonu Kumar, Anita Sarkar, Philip J. M. Brouwer, Yuanzi Hua, Monica Tolazzi, Edith Schermer, Jonathan L. Torres, Gabriel Ozorowski, Patricia van der Woude, Alba Torrents de la Peña, Mariëlle J. van Breemen, Juan Miguel Camacho-Sánchez, Judith A. Burger, Max Medina-Ramírez, Nuria González, Jose Alcami, Celia LaBranche, Gabriella Scarlatti, Marit J. van Gils, Max Crispin, David C. Montefiori, Andrew B. Ward, Gerrit Koopman, John P. Moore, Robin J. Shattock, Willy M. Bogers, Ian A. Wilson, Rogier W. Sanders
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Stabilized, native-like trimers of the HIV envelope protein, such as SOSIP trimers, are potential antigens for an HIV vaccine. Here, the authors generate a SOSIP trimer based on the consensus sequence of group M isolates, determine its structure and
Externí odkaz:
https://doaj.org/article/385d5edce0af48848af24fbfd3bba2e8
Autor:
Alba Torrents de la Peña, Kwinten Sliepen, Lisa Eshun-Wilson, Maddy Newby, Joel D. Allen, Sylvie Koekkoek, Ian Zon, Ana Chumbe, Max Crispin, Janke Schinkel, Gabriel C. Lander, Rogier W. Sanders, Andrew B. Ward
Publikováno v:
Science, 378(6617), 263-269. American Association for the Advancement of Science
Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma in humans, and afflicts more than 58 million people worldwide. The HCV envelope E1 and E2 glycoproteins are essential for viral ent