Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages

Autor: Gabrielsson Susanne, Sjöstrand Margareta, Bossios Apostolos, Torregrosa Paredes Patricia, Eldh Maria, Ekström Karin, Seyed Alikhani Vesta, Lässer Cecilia, Lötvall Jan, Valadi Hadi

Publikováno v: Journal of Translational Medicine, Vol 9, Iss 1, p 9 (2011)

Abstract Background Exosomes are 30-100 nm membrane vesicles of endocytic origin produced by numerous cells. They can mediate diverse biological functions, including antigen presentation. Exosomes have recently been shown to contain functional RNA, w

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β7 integrins are required to give rise to intestinal mononuclear phagocytes with tolerogenic potential.

Autor: Villablanca EJ; Gastrointestinal Unit, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts, USA., De Calisto J; Gastrointestinal Unit, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts, USA., Torregrosa Paredes P; Gastrointestinal Unit, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts, USA Department of Medicine, Translational Immunology Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden., Cassani B; Gastrointestinal Unit, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts, USA., Nguyen DD; Gastrointestinal Unit, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts, USA., Gabrielsson S; Department of Medicine, Translational Immunology Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden., Mora JR; Gastrointestinal Unit, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts, USA.

Publikováno v: Gut [Gut] 2014 Sep; Vol. 63 (9), pp. 1431-40. Date of Electronic Publication: 2013 Sep 12.