Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Tormod, Fladby"'
Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer’s disease
Autor:
Fernando Gonzalez-Ortiz, Bjørn-Eivind Kirsebom, José Contador, Jordan E. Tanley, Per Selnes, Berglind Gísladóttir, Lene Pålhaugen, Mathilde Suhr Hemminghyth, Jonas Jarholm, Ragnhild Skogseth, Geir Bråthen, Gøril Grøndtvedt, Atle Bjørnerud, Sandra Tecelao, Knut Waterloo, Dag Aarsland, Aida Fernández-Lebrero, Greta García-Escobar, Irene Navalpotro-Gómez, Michael Turton, Agnes Hesthamar, Przemyslaw R. Kac, Johanna Nilsson, Jose Luchsinger, Kathleen M. Hayden, Peter Harrison, Albert Puig-Pijoan, Henrik Zetterberg, Timothy M. Hughes, Marc Suárez-Calvet, Thomas K. Karikari, Tormod Fladby, Kaj Blennow
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Staging amyloid-beta (Aβ) pathophysiology according to the intensity of neurodegeneration could identify individuals at risk for cognitive decline in Alzheimer’s disease (AD). In blood, phosphorylated tau (p-tau) associates with Aβ patho
Externí odkaz:
https://doaj.org/article/b027901016fa4e8ba7386d92b8d8e45e
Autor:
Cecilia Magdalena Eriksson, Bjørn-Eivind Kirsebom, Ragna Espenes, Nikias Siafarikas, Knut Waterloo, Arvid Rongve, Per Selnes, Dag Aarsland, Tormod Fladby, Erik Hessen
Publikováno v:
Dementia and Geriatric Cognitive Disorders Extra (2024)
ABSTRACT INTRODUCTION: Depressive symptoms are associated with Alzheimer’s disease (AD), but their neurobiological and neuropsychological correlates remain poorly understood. We investigate if depressive symptoms are associated with amyloid (Aβ) p
Externí odkaz:
https://doaj.org/article/39b4331569af4ec3b84f80bb3883ae8d
Autor:
Kaja Nordengen, Bjørn-Eivind Kirsebom, Grit Richter, Lene Pålhaugen, Berglind Gísladóttir, Nikias Siafarikas, Arne Nakling, Arvid Rongve, Geir Bråthen, Gøril Rolfseng Grøntvedt, Fernando Gonzalez, Knut Waterloo, Kulbhushan Sharma, Thomas Karikari, Eleonora M. Vromen, Betty M. Tijms, Pieter J. Visser, Per Selnes, Milicia G. Kramberger, Bengt Winblad, Kaj Blennow, Tormod Fladby
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-16 (2023)
Abstract Background Brain innate immune activation is associated with Alzheimer’s disease (AD), but degrees of activation may vary between disease stages. Thus, brain innate immune activation must be assessed in longitudinal clinical studies that i
Externí odkaz:
https://doaj.org/article/e8a9047557934ffca73d41a8657fb122
Autor:
Catherine Morgan, Frederik Barkhof, David L Thomas, Saima Hilal, Moritz Brandt, Betty M Tijms, Majon Muller, Tormod Fladby, Jennifer Linn, Per Selnes, Atle Bjørnerud, Elsmarieke M van de Giessen, Beatriz Padrela, Amnah Mahroo, Mervin Tee, Markus H Sneve, Paulien Moyaert, Oliver Geier, Joost P A Kuijer, Soetkin Beun, Wibeke Nordhøy, Yufei David Zhu, Mareike A Buck, Daniel C Hoinkiss, Simon Konstandin, Jörn Huber, Julia Wiersinga, Roos Rikken, Diederick de Leeuw, Håkon Grydeland, Lynette Tippett, Erin E Cawston, Esin Ozturk-Isik, Anders Fjell, Kristine Walhovd, Lene Pålhaugen, Patricia Clement, Eric Achten, Udunna Anazodo, Klaus Eickel, Jan Petr, Matthias Günther, Henk J M M Mutsaerts
Publikováno v:
BMJ Open, Vol 14, Iss 3 (2024)
Introduction Loss of blood-brain barrier (BBB) integrity is hypothesised to be one of the earliest microvascular signs of Alzheimer’s disease (AD). Existing BBB integrity imaging methods involve contrast agents or ionising radiation, and pose limit
Externí odkaz:
https://doaj.org/article/cb019857e39c403eb369f2a40b1fec37
Autor:
Mostafa Mehdipour Ghazi, Per Selnes, Santiago Timón-Reina, Sandra Tecelão, Silvia Ingala, Atle Bjørnerud, Bjørn-Eivind Kirsebom, Tormod Fladby, Mads Nielsen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionEfforts to develop cost-effective approaches for detecting amyloid pathology in Alzheimer's disease (AD) have gained significant momentum with a focus on biomarker classification. Recent research has explored non-invasive and readily acce
Externí odkaz:
https://doaj.org/article/5aa00918684b4d0ab048ec6a1d6f0aae
Autor:
Julia K. Gundersen, Fernando Gonzalez-Ortiz, Thomas Karikari, Bjørn-Eivind Kirsebom, Katrin Mertes, Henrik Zetterberg, Hlin Kvartsberg, Ole Morten Rønning, Berglind Gísladóttir, Kaj Blennow, Tormod Fladby
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100291- (2024)
Introduction: Diagnosis of acute ischemic stroke (AIS) as based on clinical examination and neuroimaging has limitations in determining subgroup aetiology and subsequent long-term motor and cognitive impairment. Identification of high-risk patients e
Externí odkaz:
https://doaj.org/article/91cbf6f4238f40b4a713303257d1f3a9
Autor:
Jonas Jarholm, Sandra Tecelão, Lene Pålhaugen, Atle Bjørnerud, Bjørn Eivind Kirsebom, Tormod Fladby, Per Selnes
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100303- (2024)
Introduction: Alzheimer's disease (AD) and cerebral small vessel disease (SVD) frequently coexist, and increasing evidence suggest that microvascular changes may be related to AD pathology. SVD is however heterogeneously expressed on magnetic resonan
Externí odkaz:
https://doaj.org/article/e2a295980a654b7fa2809c0fd73777c3
Autor:
Lene Pålhaugen, Berglind Gísladóttir, Jonas Alexander Jarholm, Bjørn-Eivind Kirsebom, Per Selnes, Tormod Fladby
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100304- (2024)
Introduction: Angiogenic mediators like placental growth factor (PlGF) and vascular endothelial growth factors (VEFG-C and VEFG-A) in cerebrospinal fluid (CSF) are suggested markers of cerebral small vessel disease (SVD). SVD is a cause of vascular c
Externí odkaz:
https://doaj.org/article/5010ea89e7b24359981c91198ae1e63e
Autor:
Beatriz Padrela, Amnah Mahroo, Mervin Tee, Markus Sneve, Paulien Moyaert, Oliver Geier, Joost Kuijer, Soetkin Beun, Wibeke Nordhøy, Yufei David Zhu, Mareike Buck, Daniel Hoinkiss, Simon Konstandin, Jörn Huber, Julia Wiersinga, Roos Rikken, Diederick de Leeuw, Håkon Grydeland, Lynette Tippett, Erin Cawston, Esin Ozturk-Isik, Jennifer Linn, Moritz Brandt, Betty Tijms, Elsmarieke van de Giessen, Majon Muller, Anders Fjell, Kristine Walhovd, Lene Pålhaugen, Per Selnes, Patricia Clement, Eric Achten, Udunna Anazodo, Frederik Barkhof, Saima Hilal, Tormod Fladby, Klaus Eickel, Catherine Morgan, David Thomas, Jan Petr, Matthias Günther, Henk J.M.M. Mutsaerts
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100308- (2024)
Introduction: Arterial spin labeling (ASL) MRI, a non-invasive technique for imaging perfusion, now allows studying BBB permeability. The DEveloping BBB-ASL as a non-Invasive Early biomarker of Alzheimer's Disease (DEBBIE-AD) multi-cohort study integ
Externí odkaz:
https://doaj.org/article/f9e4cf3484fb4567aa9f9f8b10272e40
Autor:
Therese Händel Waggestad, Bjørn Eivind Kirsebom, Carsten Strobel, Anders Wallin, Marie Eckerström, Tormod Fladby, Jens Egeland
Publikováno v:
Frontiers in Psychology, Vol 14 (2023)
ObjectiveThe Trail Making Test (TMT) is commonly used worldwide to evaluate cognitive decline and car driving ability. However, it has received critique for its dependence on the Latin alphabet and thus, the risk of misclassifying some participants.
Externí odkaz:
https://doaj.org/article/e2072b8966ef401185f3a0835711e119