Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Torin Waters"'
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background The treatment of Ewing sarcoma, an aggressive bone and soft tissue sarcoma, is associated with suboptimal outcomes and significant side-effects. Consequently, there is an urgent need to identify novel therapies that will improve o
Externí odkaz:
https://doaj.org/article/c6df154561694243885a70d3e046906f
Autor:
Kelli L. Goss, Peter M. Gordon, Kuo Kuang Wen, William W. Terry, Torin Waters, Jason Ostergaard, David Gordon, Meng Wu, Stacia L. Koppenhafer
Publikováno v:
Oncogene
Ribonucleotide reductase (RNR), which is a heterodimeric tetramer composed of RRM1 and RRM2 subunits, is the rate-limiting enzyme in the synthesis of deoxyribonucleoside triphosphates (dNTPs) and essential for both DNA replication and the repair of D