Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Toria Tomasek"'
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Akademický článek
Blocking P2X7 receptor with AZ 10606120 exacerbates vascular hyperpermeability and inflammation in murine polymicrobial sepsis
Autor: Jamie E. Meegan, Padmini Komalavilas, Joyce Cheung‐Flynn, Tsz Wing Yim, Nathan D. Putz, Jordan J. Jesse, Kyle D. Smith, Tatiana N. Sidorova, Han Noo Ri Lee, Toria Tomasek, Ciara M. Shaver, Lorraine B. Ware, Colleen M. Brophy, Julie A. Bastarache
Publikováno v: Physiological Reports, Vol 10, Iss 11, Pp n/a-n/a (2022)
Abstract Sepsis is a devastating disease with high morbidity and mortality and no specific treatments. The pathophysiology of sepsis involves a hyperinflammatory response and release of damage‐associated molecular patterns (DAMPs), including adenos
Externí odkaz: https://doaj.org/article/c442a96d140a4867a2a4fce0591bff3d
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2
Hemoglobin increases leukocyte adhesion and initiates lung microvascular endothelial activation via Toll-like receptor 4 signaling
Autor: Adrienne K. Conger, Toria Tomasek, Kyle J. Riedmann, Joel S. Douglas, Lucia E. Berkey, Lorraine B. Ware, Julie A. Bastarache, Jamie E. Meegan
Publikováno v: American Journal of Physiology-Cell Physiology. 324:C665-C673
Cell-free hemoglobin is a pathophysiological driver of endothelial injury during sepsis and acute respiratory distress syndrome (ARDS), but the precise mechanisms are not fully understood. We hypothesized that hemoglobin (Hb) increases leukocyte adhe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b64032fc5aab934d9596d2f5009cf77
https://doi.org/10.1152/ajpcell.00211.2022
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3
Cell-free hemoglobin-mediated human lung microvascular endothelial barrier dysfunction is not mediated by cell death
Autor: Julie A. Bastarache, Jamie E. Meegan, Lorraine B. Ware, Toria Tomasek
Publikováno v: Biochem Biophys Res Commun
Circulating cell-free hemoglobin (CFH) contributes to endothelial injury in several inflammatory and hemolytic conditions. We and others have shown that CFH causes increased endothelial permeability, but the precise mechanisms of CFH-mediated endothe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0624f9d69338b75644ae048c8ac7d7
https://doi.org/10.1016/j.bbrc.2021.03.161
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