The genetic landscape of basal ganglia and implications for common brain disorders

Autor: Shahram Bahrami, Kaja Nordengen, Jaroslav Rokicki, Alexey A. Shadrin, Zillur Rahman, Olav B. Smeland, Piotr P. Jaholkowski, Nadine Parker, Pravesh Parekh, Kevin S. O’Connell, Torbjørn Elvsåshagen, Mathias Toft, Srdjan Djurovic, Anders M. Dale, Lars T. Westlye, Tobias Kaufmann, Ole A. Andreassen

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract The basal ganglia are subcortical brain structures involved in motor control, cognition, and emotion regulation. We conducted univariate and multivariate genome-wide association analyses (GWAS) to explore the genetic architecture of basal ga

Externí odkaz: https://doaj.org/article/2f1f263ef851499c8530865075d76cf0

Evidence for widespread alterations in cortical microstructure after 32 h of sleep deprivation

Autor: Irene Voldsbekk, Atle Bjørnerud, Inge Groote, Nathalia Zak, Daniel Roelfs, Ivan I. Maximov, Oliver Geier, Paulina Due-Tønnessen, Erlend Bøen, Yvonne S. Kuiper, Lise-Linn Løkken, Marie Strømstad, Taran Y. Blakstvedt, Bjørn Bjorvatn, Ulrik F. Malt, Lars T. Westlye, Torbjørn Elvsåshagen, Håkon Grydeland

Publikováno v: Translational Psychiatry, Vol 12, Iss 1, Pp 1-8 (2022)

Abstract Cortical microstructure is influenced by circadian rhythm and sleep deprivation, yet the precise underpinnings of these effects remain unclear. The ratio between T1-weighted and T2-weighted magnetic resonance images (T1w/T2w ratio) has been

Externí odkaz: https://doaj.org/article/40cb1f8f86634ca493124c6f7655c2b4

Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes

Autor: Linn Rødevand, Shahram Bahrami, Oleksandr Frei, Yunhan Chu, Alexey Shadrin, Kevin S. O’Connell, Olav B. Smeland, Torbjørn Elvsåshagen, Guy F. L. Hindley, Srdjan Djurovic, Anders M. Dale, Trine V. Lagerberg, Nils Eiel Steen, Ole A. Andreassen

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract Patients with bipolar disorder (BIP) have a high risk of cardiovascular disease (CVD), despite considerable individual variation. The mechanisms underlying comorbid CVD in BIP remain largely unknown. We investigated polygenic overlap between

Externí odkaz: https://doaj.org/article/df29ce5597ec4670ae2c6751050c2698

Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms

Autor: Linn Rødevand, Shahram Bahrami, Oleksandr Frei, Aihua Lin, Osman Gani, Alexey Shadrin, Olav B. Smeland, Kevin S. O’ Connell, Torbjørn Elvsåshagen, Adriano Winterton, Daniel S. Quintana, Guy F. L. Hindley, Maren C. F. Werner, Srdjan Djurovic, Anders M. Dale, Trine V. Lagerberg, Nils Eiel Steen, Ole A. Andreassen

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Clinical and epidemiological evidence suggest that loneliness is associated with severe mental disorders (SMDs) and increases the risk of cardiovascular disease (CVD). However, the mechanisms underlying the relationship between loneliness, S

Externí odkaz: https://doaj.org/article/f26113d436354fa1a0c8a0ba0dba7944

The genetic architecture of human brainstem structures and their involvement in common brain disorders

Autor: Torbjørn Elvsåshagen, Shahram Bahrami, Dennis van der Meer, Ingrid Agartz, Dag Alnæs, Deanna M. Barch, Ramona Baur-Streubel, Alessandro Bertolino, Mona K. Beyer, Giuseppe Blasi, Stefan Borgwardt, Birgitte Boye, Jan Buitelaar, Erlend Bøen, Elisabeth Gulowsen Celius, Simon Cervenka, Annette Conzelmann, David Coynel, Pasquale Di Carlo, Srdjan Djurovic, Sarah Eisenacher, Thomas Espeseth, Helena Fatouros-Bergman, Lena Flyckt, Barbara Franke, Oleksandr Frei, Barbara Gelao, Hanne Flinstad Harbo, Catharina A. Hartman, Asta Håberg, Dirk Heslenfeld, Pieter J. Hoekstra, Einar A. Høgestøl, Rune Jonassen, Erik G. Jönsson, Karolinska Schizophrenia Project (KaSP) consortium, Peter Kirsch, Iwona Kłoszewska, Trine Vik Lagerberg, Nils Inge Landrø, Stephanie Le Hellard, Klaus-Peter Lesch, Luigi A. Maglanoc, Ulrik F. Malt, Patrizia Mecocci, Ingrid Melle, Andreas Meyer-Lindenberg, Torgeir Moberget, Jan Egil Nordvik, Lars Nyberg, Kevin S. O’ Connell, Jaap Oosterlaan, Marco Papalino, Andreas Papassotiropoulos, Paul Pauli, Giulio Pergola, Karin Persson, Dominique de Quervain, Andreas Reif, Jaroslav Rokicki, Daan van Rooij, Alexey A. Shadrin, André Schmidt, Emanuel Schwarz, Geir Selbæk, Hilkka Soininen, Piotr Sowa, Vidar M. Steen, Magda Tsolaki, Bruno Vellas, Lei Wang, Eric Westman, Georg C. Ziegler, Mathias Zink, Ole A. Andreassen, Lars T. Westlye, Tobias Kaufmann

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

The genetic architecture underlying brainstem regions and how this links to common brain disorders is not well understood. Here, the authors use MRI and GWAS data from 27,034 individuals to identify genetic and morphological brainstem features that i

Externí odkaz: https://doaj.org/article/bb60787933434b12ab5b236140b403a3