Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Torben Moos"'
Autor:
Steinunn Sara Helgudóttir, Kasper Bendix Johnsen, Lisa Greve Routhe, Charlotte Laurfelt Munch Rasmussen, Maj Schneider Thomsen, Torben Moos
Publikováno v:
Cells, Vol 13, Iss 14, p 1181 (2024)
Background: Transferrin receptor 1 (TfR1), glucose transporter 1 (GLUT1), and CD98hc are candidates for targeted therapy at the blood–brain barrier (BBB). Our objective was to challenge the expression of TfR1, GLUT1, and CD98hc in brain capillaries
Externí odkaz:
https://doaj.org/article/ab947a73d6634cf9af1885d14fd180bd
Autor:
Annette Burkhart, Torben Moos
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 668-670 (2023)
Externí odkaz:
https://doaj.org/article/2d6799371e9448c3b1cd82eaf026d33a
Autor:
Krzysztof Kucharz, Kasper Kristensen, Kasper Bendix Johnsen, Mette Aagaard Lund, Micael Lønstrup, Torben Moos, Thomas Lars Andresen, Martin Johannes Lauritzen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Limited understanding of the interactions between nanoparticle drug carriers and the blood-brain barrier underlies many translational failures in treatments of brain disorders. Here the authors use two-photon microscopy in mice to characterize the re
Externí odkaz:
https://doaj.org/article/3ecb3577f7e2486e85315477978e25ca
Autor:
Pawel Stocki, Jaroslaw Szary, Mykhaylo Demydchuk, Leandra Northall, Charlotte L. M. Rasmussen, Diana Bahu Logan, Aziz Gauhar, Laura Thei, Shu-Fen Coker, Torben Moos, Frank S. Walsh, J. Lynn Rutkowski
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 739 (2023)
Since the delivery of biologic drugs to the brain is greatly hampered by the existence of the blood–brain barrier (BBB), brain shuttles are being developed to enhance therapeutic efficacy. As we have previously shown, efficient and selective brain
Externí odkaz:
https://doaj.org/article/82000d2623a94836867f72035c2923dd
Autor:
Emma Lisa Al Humaidan, Sidse Lund Pedersen, Annette Burkhart, Charlotte Laurfelt Munch Rasmussen, Torben Moos, Peter Fuchs, Eduardo Filipe Alves Fernandes, Burak Ozgür, Kristian Strømgaard, Anders Bach, Birger Brodin, Mie Kristensen
Publikováno v:
Frontiers in Drug Delivery, Vol 2 (2022)
Inhibition of the interaction between the scaffolding protein PSD-95 and the NMDA receptor has been shown to obstruct ischemic stroke-triggered excitotoxic reactions, leading to neuronal death. The peptides NR2B9c and N-dimer are inhibitors of this i
Externí odkaz:
https://doaj.org/article/2a20fa73db6c4bf6b23bd3a0ffc393a8
Autor:
Veronika Markova, Rebecka Hansen, Lars Lykke Thomsen, Anja Pinborg, Torben Moos, Charlotte Holm
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background Iron deficiency is common in pregnancy. If left untreated, iron deficiency can lead to iron deficiency anaemia, which is a condition related to maternal and neonatal morbidity. The prevalence of iron deficiency increases through t
Externí odkaz:
https://doaj.org/article/ea9b78528b0b4d94b4e43dcdf74b1abd
Autor:
Louise Berkhoudt Lassen, Maj Schneider Thomsen, Elisa Basso, Ernst-Martin Füchtbauer, Annette Füchtbauer, Tiago Fleming Outeiro, Poul Henning Jensen, Torben Moos
Publikováno v:
Cells, Vol 11, Iss 22, p 3673 (2022)
Overexpression of α-synuclein with tyrosine mutated to phenylalanine at position 125 leads to a severe phenotype with motor impairment and neuropathology in Drosophila. Here, we hypothesized that tyrosine mutations would similarly lead to impaired m
Externí odkaz:
https://doaj.org/article/9f9fdc3b3980405c9cf55375a16e7e4a
Autor:
Maj Schneider Thomsen, Kasper Bendix Johnsen, Krzysztof Kucharz, Martin Lauritzen, Torben Moos
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2237 (2022)
The blood–brain barrier (BBB), built by brain endothelial cells (BECs), is impermeable to biologics. Liposomes and other nanoparticles are good candidates for the delivery of biologics across the BECs, as they can encapsulate numerous molecules of
Externí odkaz:
https://doaj.org/article/032e5a6f16ef45dc9d4dac4f340b4596
Autor:
Torben Moos, Lisbeth B. Møller
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Externí odkaz:
https://doaj.org/article/08a6157df1ae45d583696841b3d59ac7
Autor:
Maj Schneider Thomsen, Nanna Humle, Eva Hede, Torben Moos, Annette Burkhart, Louiza Bohn Thomsen
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0236770 (2021)
The blood-brain barrier (BBB) is formed by brain capillary endothelial cells (BECs) supported by pericytes and astrocytes. The BBB maintains homeostasis and protects the brain against toxic substances circulating in the blood, meaning that only a few
Externí odkaz:
https://doaj.org/article/7c9ea220510344e48502772797a9c61d