Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Torben J Hausrat"'
Autor:
André T Lopes, Torben J Hausrat, Frank F Heisler, Kira V Gromova, Franco L Lombino, Timo Fischer, Laura Ruschkies, Petra Breiden, Edda Thies, Irm Hermans-Borgmeyer, Michaela Schweizer, Jürgen R Schwarz, Christian Lohr, Matthias Kneussel
Publikováno v:
PLoS Biology, Vol 18, Iss 8, p e3000820 (2020)
Mutations in the gene encoding the microtubule-severing protein spastin (spastic paraplegia 4 [SPG4]) cause hereditary spastic paraplegia (HSP), associated with neurodegeneration, spasticity, and motor impairment. Complicated forms (complicated HSP [
Externí odkaz:
https://doaj.org/article/fd94a10cc9314b0d9d95e7c1e309a73e
Autor:
Jennifer Radwitz, Torben J. Hausrat, Frank F. Heisler, Philipp C. Janiesch, Yvonne Pechmann, Michael Rübhausen, Matthias Kneussel
Publikováno v:
Cellular and Molecular Life Sciences. 79
Microtubules are dynamic polymers of α/β-tubulin. They regulate cell structure, cell division, cell migration, and intracellular transport. However, functional contributions of individual tubulin isotypes are incompletely understood. The neuron-spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d61512d49485938e7204018c9318055f
https://doi.org/10.1007/s00018-022-04607-5
https://doi.org/10.1007/s00018-022-04607-5
Publikováno v:
Developmental Neurobiology. 81:333-350
Alpha- and beta-tubulin dimers polymerize into protofilaments that associate laterally to constitute a hollow tube, the microtubule. A dynamic network of interlinking filaments forms the microtubule cytoskeleton, which maintains the structure of cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083c0f8d0f432c3cd481538a2955f542
https://doi.org/10.1002/dneu.22745
https://doi.org/10.1002/dneu.22745
Autor:
Sabine A. H. Hoffmeister-Ullerich, Michael R. Kreutz, Laura Ruschkies, Jessica E. M. Dunleavy, Melanie Richter, Monika S. Brill, Thomas Misgeld, Franco L. Lombino, Edda Thies, Michael Frotscher, André T. Lopes, Torben J. Hausrat, David Lutz, Froylan Calderon de Anda, Mary Muhia, Francis J. McNally, Jeffrey Lopez-Rojas, Irm Hermans-Borgmeyer, Matthias Kneussel
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific reports, 9:15940
Scientific reports, vol 9, iss 1
Scientific Reports
Scientific reports, 9:15940
Scientific reports, vol 9, iss 1
Microtubule severing regulates cytoskeletal rearrangement underlying various cellular functions. Katanin, a heterodimer, consisting of catalytic (p60) and regulatory (p80) subunits severs dynamic microtubules to modulate several stages of cell divisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166efaa6b8e3f7367fa7a47152ee290b
http://link.springer.com/article/10.1038/s41598-019-52367-3
http://link.springer.com/article/10.1038/s41598-019-52367-3
Publikováno v:
Developmental Neurobiology. 81
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9077289c688ea55b255fb46f45c54060
https://doi.org/10.1002/dneu.22822
https://doi.org/10.1002/dneu.22822
Autor:
Aleksandar Rakovic, Jin-Sung Park, Christine Klein, Carolyn M. Sue, Philip Seibler, Torben J. Hausrat, Victor Krajka, Franca Vulinovic, Daniel Alvarez-Fischer, Harutyun Madoev, Kishore R. Kumar, Matthias Kneussel, Katja Lohmann
Publikováno v:
Human Mutation. 39:1901-1915
Mutations in TUBB4A have been identified to cause a wide phenotypic spectrum of diseases ranging from hereditary generalized dystonia with whispering dysphonia (DYT-TUBB4A) and hereditary spastic paraplegia (HSP) to leukodystrophy hypomyelination wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea5f239dc0da03160e53bca3c5e94e1
https://doi.org/10.1002/humu.23602
https://doi.org/10.1002/humu.23602
Autor:
Anna Karpova, Tamar Macharadze, Nicola Brice, Antonio Virgilio Failla, Syed Ahsan Raza, Ioana Butnaru, Michael R. Kreutz, Matthias Kneussel, Eckart D. Gundelfinger, Jeffrey Lopez-Rojas, Christina Spilker, Rajeev Raman, Silvia Diaz-Gonzalez, Oliver Stork, PingAn Yuanxiang, Mark Carlton, Michaela Schweizer, Torben J. Hausrat, Guilherme M. Gomes, Maria Andres-Alonso, Mohamed-Raafet Ammar, Gustavo Acuna Sanhueza, Maximilian Borgmeyer
SummaryAmphisomes are transient organelles that derive from fusion of autophagosomes with late endosomes. They rapidly transform into degradative autolysosomes, whereas non-degradative roles of the autophagic pathway have been barely described. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ebd6ed5e36eadcb249cf7655c80648
Autor:
Nicola Brice, Michael R. Kreutz, Jeffrey Lopez-Rojas, Christina Spilker, Oliver Stork, Maria Andres-Alonso, Torben J. Hausrat, Michaela Schweizer, Mohamed-Raafet Ammar, Gustavo Acuna Sanhueza, Guilherme M. Gomes, Maximilian Borgmeyer, Ioana Butnaru, Anna Karpova, Silvia Diaz-Gonzalez, Rajeev Raman, PingAn Yuanxiang, Tamar Macharadze, Antonio Virgilio Failla, Mark Carlton, Eckart D. Gundelfinger, Syed Ahsan Raza, Matthias Kneussel
Publikováno v:
Nature Communications
Nature Communications, 10(1):5448
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications, 10(1):5448
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Amphisomes are organelles of the autophagy pathway that result from the fusion of autophagosomes with late endosomes. While biogenesis of autophagosomes and late endosomes occurs continuously at axon terminals, non-degradative roles of autophagy at b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e47965248e8ba50324b748b2c6f408
Autor:
Torben J. Hausrat, Sören Doose, Kristian Strømgaard, Matthias Kneussel, Franziska Neubert, Nils Ole Dalby, Hans Michael Maric, Markus Sauer
Publikováno v:
Nature Chemical Biology. 13:153-160
γ-Aminobutyric acid type A and glycine receptors are the major mediators of fast synaptic inhibition in the human central nervous system and are established drug targets. However, all drugs targeting these receptors bind to the extracellular ligand-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e6562c2296b49961c358c8fbfefe5e
https://doi.org/10.1038/nchembio.2246
https://doi.org/10.1038/nchembio.2246
Autor:
Torben J. Hausrat, Matthias Kneussel
Publikováno v:
Trends in Neurosciences. 39:170-182
At excitatory and inhibitory synapses, an immediate transfer of additional neurotransmitter receptors from non-synaptic positions to the synapse mediates synaptic long-term potentiation (LTP). Different types of non-synaptic reserve pools permit the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d68c137f814d69148c22d87b0c88ac
https://doi.org/10.1016/j.tins.2016.01.002
https://doi.org/10.1016/j.tins.2016.01.002