Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Torben Bruhn"'
Publikováno v:
Neurobiology of Disease, Vol 1, Iss 3, Pp 131-138 (1994)
Systemic administration of salicylate (SA) to rats (100 mg kg−1i.p.) was used as anin vivotrap of hydroxyl radicals (·OH). In the brain SA reacts with hydroxyl radicals to form the stable adducts 2,3- and 2,5 dihydroxybenzoic acid (DHBAs) which ca
Externí odkaz:
https://doaj.org/article/5aa2abfeca0d449a9977873245217dd2
Publikováno v:
University of Copenhagen
The effect of the free radical spin-trap alpha-phenyl-butyl-tert-nitrone (alpha-PBN) in permanent focal cerebral ischemia in rats was examined in two series of experiments. In the first, rats were subjected to permanent occlusion of the middle cerebr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6138b0a01f7293bafe0db5aecec68f
https://doi.org/10.1016/s0006-8993(03)03439-5
https://doi.org/10.1016/s0006-8993(03)03439-5
Publikováno v:
Journal of Neuroscience Research. 71:551-558
By using microdialysis extraction of 3H-D-aspartate and concomitant recordings of extracellular direct current (DC) potentials, the effect of middle cerebral artery occlusion (MCAO) was studied continuously over a period of 100 min in the cerebral co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151c747e8b9523f2637742063d009ff6
https://doi.org/10.1002/jnr.10492
https://doi.org/10.1002/jnr.10492
Publikováno v:
Journal of Neuroscience Research. 66:1118-1126
Using microdialysis in CA1 of the rat hippocampus, we studied the effect of transient cerebral ischemia on in vivo uptake and on extracellular levels of glutamate during, and at different time points after ischemia. (3)H-D-aspartate (test substance),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba93025705e77220f5504fc4bb477af
https://doi.org/10.1002/jnr.10011
https://doi.org/10.1002/jnr.10011
Publikováno v:
Neuroscience Research Communications. 26:77-86
Recently it was reported that the opioid analgesic ketobemidone in addition to being a potent opioid receptor agonist at the μ receptor also is a weak non-competitive antagonist at glutamate receptors of the NMDA subtype. Since NMDA antagonists cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9d3607ee8f5bf73b3c90e9e83a2a325
https://doi.org/10.1002/(sici)1520-6769(200003/04)26:2<77::aid-nrc2>3.0.co
https://doi.org/10.1002/(sici)1520-6769(200003/04)26:2<77::aid-nrc2>3.0.co
Publikováno v:
University of Copenhagen
A double-tracer autoradiographic method for simultaneous measurement of regional glucose utilization (rCMRglc) and regional protein synthesis (PS) in consecutive brain sections is described and applied to study the metabolism of the ischemic penumbra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ea7012c572c410d98f778bc348ebe9
https://doi.org/10.1080/01616412.1999.11740999
https://doi.org/10.1080/01616412.1999.11740999
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 17:147-152
The α-amino-3-hydroxy-5-methyl-4-isoxazole (AMPA) receptor antagonist, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo( F)quinoxaline (NBQX), offers protection to hippocampal CA1 pyramidal cells after short episodes of transient cerebral ischemia. Besides C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e99c69acb763ff122bdc74e2e2f3d63
https://doi.org/10.1097/00004647-199702000-00003
https://doi.org/10.1097/00004647-199702000-00003
Publikováno v:
Epilepsy Research. 26:363-371
Using a newly developed technique, based on microdialysis, which allows cellular uptake of glutamate and aspartate to be studied in awake animals, we investigated uptake of glutamate and aspartate in the hippocampal formation of rats during limbic se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ea564bf07d3a8420f87100c662daaa4
https://doi.org/10.1016/s0920-1211(96)01003-0
https://doi.org/10.1016/s0920-1211(96)01003-0
Autor:
Inge Damgaard, Torben Bruhn, Arne Schousboe, Thomas Christensen, Nils Henrik Diemer, Manuela Cobo
Publikováno v:
Journal of Neuroscience Research. 46:198-203
Swelling-induced release of taurine was investigated in vivo in hippocampus by microdialysis or in vitro in cultured neocortical neurons or astrocytes. Swelling was induced either by increasing the extracellular K+ concentration or by exposing the ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f78266236859c30c113bec829229c33
https://doi.org/10.1002/(sici)1097-4547(19961015)46:2<198::aid-jnr7>3.0.co
https://doi.org/10.1002/(sici)1097-4547(19961015)46:2<198::aid-jnr7>3.0.co
Publikováno v:
University of Copenhagen
The role of glutamate as a possible mediator of neurodegeneration is well described, and the homeostasis of extracellular glutamate is considered of major importance when addressing the pathogenesis of excitatory neurodegeneration. Applying the ‘in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8db6b20814960daaa25a9d7c841bac
https://doi.org/10.1016/0165-0270(94)00179-k
https://doi.org/10.1016/0165-0270(94)00179-k