Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Tor Svensson"'
1
The regulatory role of PGC1α‐related coactivator in response to drug‐induced liver injury
Autor: Richard C. Scarpulla, Björn Glinghammar, Johan Mattsson, Ulf Andersson, Tor Svensson, Thomas Naessens, Marcin Buler, Lillevi Kärrberg, Yannick Morias, Petra Thulin, Philip Robbins, Magnus Söderberg
Publikováno v: FASEB BioAdvances
FASEB BioAdvances, Vol 2, Iss 8, Pp 453-463 (2020)
PGC1α‐Related Coactivator (PRC) is a transcriptional coactivator promoting cytokine expression in vitro in response to mitochondrial injury and oxidative stress, however, its physiological role has remained elusive. Herein we investigate aspects o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94549d5ea514b493414170c62d00baae
http://europepmc.org/articles/PMC7429352
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2
How well does molecular simulation reproduce environment-specific conformations of the intrinsically disordered peptides PLP, TP2 and ONEG?
Autor: Lauren M. Reid, Ileana Guzzetti, Tor Svensson, Anna-Carin Carlsson, Wu Su, Tomas Leek, Lena von Sydow, Werngard Czechtizky, Marija Miljak, Chandra Verma, Leonardo De Maria, Jonathan W. Essex
Understanding the conformational ensembles of intrinsically disordered proteins and peptides (IDPs) in their various biological environments is essential for understanding their mechanisms and functional roles in the proteome, leading to a greater kn
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a5a94ae847564f22dba11030a6f854
https://eprints.soton.ac.uk/455486/
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3
Route Optimization and Manufacture of Multihundred Grams of a Ghrelin Receptor Agonist
Autor: Tor Svensson, Marika Lindhagen, Grigorios Nikitidis, Staffan Karlsson, Cristina Gardelli
Publikováno v: Organic Process Research & Development. 22:1174-1187
A linear 14-step sequence was developed for the synthesis of an oxaspirocyclic cyclopentane-based candidate drug 1 containing four chiral centers. Compared with the first-generation synthesis with an overall yield of 0.7%, which also included several
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f0d3623b957eece79ff498e8acebaa4
https://doi.org/10.1021/acs.oprd.8b00179
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4
Discovery of triazole aminopyrazines as a highly potent and selective series of PI3Kδ inhibitors
Autor: Linda Öster, Helena Lindmark, Ina Terstiege, Jens Petersen, Perry Matthew, Tor Svensson, Christian Tyrchan
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 27:679-687
A novel class of potent PI3Kδ inhibitors with >1000-fold selectivity against other class I PI3K isoforms is described. Optimization of the substituents on a triazole aminopyrazine scaffold, emerging from an in-house PI3Kα program, turned moderately
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667d8560a853b5dcb7cb3313026d3553
https://doi.org/10.1016/j.bmcl.2016.11.004
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5
Design and Synthesis of Soluble and Cell-Permeable PI3Kδ Inhibitors for Long-Acting Inhaled Administration
Autor: Christian Tyrchan, Neil S. Holden, Nils Pemberton, Anders Eriksson, Ina Terstiege, Yunhua Chen, Hai'e Hao, Kostas Karabelas, Karin Björhall, Tor Svensson, Linda Fredlund, Wenzhen Yang, Jens Petersen, Shuchun Zhao, Perry Matthew, Johan Carlsson, Helena Lindmark, Sandra Rodrigo Blomqvist, Britta Bonn, Feifei Liu, Reed W. Smith, Linda Öster
Publikováno v: Journal of medicinal chemistry. 60(12)
PI3Kδ is a lipid kinase that is believed to be important in the migration and activation of cells of the immune system. Inhibition is hypothesized to provide a powerful yet selective immunomodulatory effect that may be beneficial for the treatment o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e58ee2991c36cf0508c4f1b564fc5b9
https://pubmed.ncbi.nlm.nih.gov/28520415
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6
Intravenous hypertonic NaCl acts via cerebral sodium-sensitive and angiotensinergic mechanisms to improve cardiac function in haemorrhaged conscious sheep
Autor: Tor Svensson, Mats Rundgren, Frida Bayard, Robert Frithiof, Stefan Eriksson
Publikováno v: The Journal of Physiology. 583:1129-1143
Acute NaCl loading as resuscitation in haemorrhagic hypovolaemia is known to induce rapid cardiovascular recovery. Besides an osmotically induced increase in plasma volume the physiological mechanisms of action are unknown. We hypothesized that a CNS
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::637341450f4eb619fc7c19d0701ee981
https://doi.org/10.1113/jphysiol.2007.139592
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8
Lactam sulfonamides as potent inhibitors of the Kv1.5 potassium ion channel
Autor: Annika Åstrand, Anna Rönnborg, Emma Lindhardt, Ulrik Gran, Gert Strandlund, Hans Emtenäs, Zhong-Qing Yuan, Jonas Boström, Johan Sundell, Jonna Gyll, Ågot Högberg, Boel Löfberg, Tommy Iliefski, Roine I. Olsson, Birgit Andersson, Olle Hidestål, Tor Svensson, Ingemar Jacobson, Elin Forsström, Frida Persson, Christina Olsson, Annika Björe, Gunilla Linhardt, Öjvind Davidsson, Ola Fjellström, Jesper Malmberg
Publikováno v: Bioorganicmedicinal chemistry letters. 24(5)
A series of lactam sulfonamides has been discovered and optimized as inhibitors of the Kv1.5 potassium ion channel for treatment of atrial fibrillation. In vitro structure–activity relationships from lead structure C to optimized structure 3y are d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71012effbd3cf129aff4e8df9e21b478
https://pubmed.ncbi.nlm.nih.gov/24513046
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9
Intravenous hypertonic NaCl acts via cerebral sodium-sensitive and angiotensinergic mechanisms to improve cardiac function in haemorrhaged conscious sheep
Autor: Robert, Frithiof, Stefan, Eriksson, Frida, Bayard, Tor, Svensson, Mats, Rundgren
Publikováno v: The Journal of physiology. 583(Pt 3)
Acute NaCl loading as resuscitation in haemorrhagic hypovolaemia is known to induce rapid cardiovascular recovery. Besides an osmotically induced increase in plasma volume the physiological mechanisms of action are unknown. We hypothesized that a CNS
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ccb791fffa42fd7b2245bc75320062d
https://pubmed.ncbi.nlm.nih.gov/17640936
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10
Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGluR5)
Autor: Tor Svensson, Alecia Peterson, Krister Österlund, David Karis, Udo Bauer, Lance G. Hammerland, Karolina Nilsson, David Wensbo, Maria Boije, Peter Bach, Andreas Wållberg
Publikováno v: Bioorganicmedicinal chemistry letters. 16(18)
Studies of structure-activity relationships for the linker in a new series of metabotropic glutamate receptor 5 antagonists are presented together with in vitro and in vivo pharmacokinetic data.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a169826f562c4c45c7621b7f2fd63d
https://pubmed.ncbi.nlm.nih.gov/16837196
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