Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Tor Savidge"'
Autor:
Advait Balaji, Nicolae Sapoval, Charlie Seto, R.A. Leo Elworth, Yilei Fu, Michael G. Nute, Tor Savidge, Santiago Segarra, Todd J. Treangen
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3208-3222 (2022)
Characterizing metagenomes via kmer-based, database-dependent taxonomic classification has yielded key insights into underlying microbiome dynamics. However, novel approaches are needed to track community dynamics and genomic flux within metagenomes,
Externí odkaz:
https://doaj.org/article/9d0a38853e674e5281e1ad9570f8be18
Autor:
Andrea Dimet-Wiley, Qinglong Wu, Jerrin T. Wiley, Aditya Eswar, Harshini Neelakantan, Tor Savidge, Stan Watowich
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Treatment with a nicotinamide N-methyltransferase inhibitor (NNMTi; 5-amino-1-methylquinolinium) combined with low-fat diet (LD) promoted dramatic whole-body adiposity and weight loss in diet-induced obese (DIO) mice, rapidly normalizing the
Externí odkaz:
https://doaj.org/article/fd5a732a491e4a779cb2ac5a045ffece
Autor:
Silvia Molino, Andrea Pisarevsky, Shyam Badu, Qinglong Wu, Fabiana López Mingorance, Patricia Vega, Juan Pablo Stefanolo, Julieta Repetti, Guillermina Ludueña, Pablo Pepa, Juan Ignacio Olmos, Marcelo Rodriguez Fermepin, Tatiana Uehara, Elisa Viciani, Andrea Castagnetti, Tor Savidge, María Marta Piskorz
Publikováno v:
Journal of Functional Foods, Vol 99, Iss , Pp 105356- (2022)
The clinical study aim was to investigate whether a tannin-based dietary supplementation could improve the efficacy of standard-of-care treatment of hospitalized COVID-19 patients by restoring gut microbiota function. Adverse events and immunomodulat
Externí odkaz:
https://doaj.org/article/26278c4da38340d3bc9e6403f5a11d01
Autor:
Joao B. Xavier, Jonathan M. Monk, Saugat Poudel, Charles J. Norsigian, Anand V. Sastry, Chen Liao, Jose Bento, Marc A. Suchard, Mario L. Arrieta-Ortiz, Eliza J.R. Peterson, Nitin S. Baliga, Thomas Stoeger, Felicia Ruffin, Reese A.K. Richardson, Catherine A. Gao, Thomas D. Horvath, Anthony M. Haag, Qinglong Wu, Tor Savidge, Michael R. Yeaman
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104079- (2022)
Summary: Mathematical models have many applications in infectious diseases: epidemiologists use them to forecast outbreaks and design containment strategies; systems biologists use them to study complex processes sustaining pathogens, from the metabo
Externí odkaz:
https://doaj.org/article/1e825332653c49c0989978d4a000ec3b
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 2, Pp 103611- (2022)
Understanding the origin of the enormous catalytic power of enzymes is very important. Electrostatic interactions and desolvation are the phenomena that are most proposed to explain the catalysis of enzymes; however, they also decelerate enzymatic re
Externí odkaz:
https://doaj.org/article/56c24f5f568d4dbb8d726f62c1707350
Autor:
Silvia Molino, Andrea Pisarevsky, Fabiana Lopez Mingorance, Patricia Vega, Juan Pablo Stefanolo, Julieta Repetti, Guillermina Ludueña, Pablo Pepa, Juan Ignacio Olmos, Marcelo Rodriguez Fermepin, Tatiana Uehara, Sonia Villapol, Tor Savidge, Todd Treangen, Elisa Viciani, Andrea Castagnetti, Maria Marta Piskorz
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-3 (2021)
Abstract Objectives This research aims to study the efficacy of tannins co-supplementation on disease duration, severity and clinical symptoms, microbiota composition and inflammatory mediators in SARS-CoV2 patients. Trial design This is a prospectiv
Externí odkaz:
https://doaj.org/article/04e505fbcd994b6cab9a696003721083
Autor:
Andrea Martinez Aguirre, Nazli Yalcinkaya, Qinglong Wu, Alton Swennes, Mary Elizabeth Tessier, Paul Roberts, Fabio Miyajima, Tor Savidge, Joseph A Sorg
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1010015 (2021)
Clostridioides difficile infections occur upon ecological / metabolic disruptions to the normal colonic microbiota, commonly due to broad-spectrum antibiotic use. Metabolism of bile acids through a 7α-dehydroxylation pathway found in select members
Externí odkaz:
https://doaj.org/article/a68d3cc2a7c4485c800df500d3fb295e
Autor:
Jennifer S. Labus, Emily B. Hollister, Jonathan Jacobs, Kyleigh Kirbach, Numan Oezguen, Arpana Gupta, Jonathan Acosta, Ruth Ann Luna, Kjersti Aagaard, James Versalovic, Tor Savidge, Elaine Hsiao, Kirsten Tillisch, Emeran A. Mayer
Publikováno v:
Microbiome, Vol 5, Iss 1, Pp 1-17 (2017)
Abstract Background Preclinical and clinical evidence supports the concept of bidirectional brain-gut microbiome interactions. We aimed to determine if subgroups of irritable bowel syndrome (IBS) subjects can be identified based on differences in gut
Externí odkaz:
https://doaj.org/article/8a43c16877064a318a257fba038eff32
Autor:
Ruth Ann Luna, Numan Oezguen, Miriam Balderas, Alamelu Venkatachalam, Jessica K. Runge, James Versalovic, Jeremy Veenstra-VanderWeele, George M. Anderson, Tor Savidge, Kent C. Williams
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 2, Pp 218-230 (2017)
Background & Aims: Emerging data on the gut microbiome in autism spectrum disorder (ASD) suggest that altered hostâmicrobe interactions may contribute to disease symptoms. Although gut microbial communities in children with ASD are reported to diffe
Externí odkaz:
https://doaj.org/article/8a11fdfbb3114208b58efc8ab6e5a9fd
Publikováno v:
Toxins, Vol 2, Iss 7, Pp 1848-1880 (2010)
The major virulence factors of Clostridium difficile infection (CDI) are two large exotoxins A (TcdA) and B (TcdB). However, our understanding of the specific roles of these toxins in CDI is still evolving. It is now accepted that both toxins are ent
Externí odkaz:
https://doaj.org/article/810103c1e0254a20acacc10b7b99ad41