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pro vyhledávání: '"Tor Refsvik"'
Publikováno v:
Acta Pharmacologica et Toxicologica. 49:190-194
Fractionation of the bile from rats injected with 65ZnCl2 (5 μmol/kg) showed that zinc was mainly bound to low molecular weight compounds eluted corresponding to the zinc-glutathione complexes. Diethylmaleate (3.9 mmol/kg), cyclohexene oxide (4.9 mm
Autor:
Tove Andreassen, Tor Refsvik
Publikováno v:
Carcinogenesis. 16(5)
The carcinogenic potency of nickel compounds depends on the ability of nickel ions to enter target cells. The presumptive preventive potential of several metals against nickel-induced cancer may depend on their capacity to inhibit nickel uptake. Surf
Autor:
Tor Refsvik
Publikováno v:
Acta Pharmacologica et Toxicologica. 55:121-125
N-acetylpenicillamine, 5 mmol/kg body weight increased biliary excretion of methyl mercury more than three fold. Upon simultaneous administration of the same dose of N-acetylpenicillamine and 2,5 mmol/kg body weight of S-methylcysteine biliary excret
Autor:
Tor Refsvik
Publikováno v:
Pharmacology & Toxicology. 60:125-128
Upon intraperitoneal administrationof N-(1-14C)-acetylpenicillamine (NAPA) to rats, at a dose of 1-2 mmol/ kg body weight, a 14C-labelled metabolite of NAPA together with unchanged NAPA were excreted in bile. The NAPA metabolite was characterized by
Autor:
Tor Refsvik
Publikováno v:
Acta pharmacologica et toxicologica. 53(2)
The S-methylated derivatives of N-acetylpenicillamine, thiola and cysteine as well as methyl iodide decreased biliary excretion of methyl mercury markedly. Excretion of sulfhydryl in bile was not influenced by S-methyl-cysteine, S-methylthiola, S-met
Autor:
Tor Refsvik, Tor Norseth
Publikováno v:
Acta pharmacologica et toxicologica. 36(1)
Methyl mercuric glutathione is the predominant methyl mercuric compound in rat bile following exposure to methyl mercuric chloride. Methyl mercuric chloride also forms methyl mercuric glutathione when added to rat bile in vitro. A small amount of met
Autor:
Tor Refsvik
Publikováno v:
Acta pharmacologica et toxicologica. 50(3)
Thioctic acid markedly increases the sulfhydryl and sulphide content of bile. This probably reflects the reduction of thioctic acid in the liver, followed by biliary excretion of a reduced derivative. The total biliary excretion of methyl mercury was
Autor:
Tor Refsvik
Publikováno v:
Acta pharmacologica et toxicologica. 52(1)
N-Acetylpenicillamine and thiola increased biliary excretion of methyl mercury and sulfhydryl right after administration. Cysteine increased excretion of methyl mercury in bile after a temporary decrease following administration. During the interval
Autor:
Tor Refsvik
Publikováno v:
Acta pharmacologica et toxicologica. 55(1)
The effect of I-chloro-2,4-dinitrobenzene (DNB), sulfobromophtalein (BSP) and cyclohexene oxide (cho) on N-acetylpenicillamine (NAPA) potentiated biliary excretion of methyl mercury in rats pretreated with cho for liver glutathione (GSH) depletion, h
Autor:
Tor Refsvik
Publikováno v:
Acta pharmacologica et toxicologica. 42(2)
Diethylmaleate, cyclohexene oxide and acrylamide administered intraperitoneally to rats, have been shown markedly to inhibit biliary excretion of methyl mercury. Simultaneously the sulphhydryl and sulphide content of the bile decreases. These results