Hereditary hemochromatosis beyond hyperferritinemia: Clinical and laboratory investigation of the patient’s profile submitted to phlebotomy in two reference centers in southern Brazil

Autor: Nathalia Kersting, Juliana Cristine Fontana, Fabiane Pohlmann de Athayde, Fernanda Marcante Carlotto, Bruna Accorsi Machado, Cristiane da Silva Rodrigues de Araújo, Leo Sekine, Tor Gunnar Hugo Onsten, Sandra Leistner-Segal

Publikováno v: Genetics and Molecular Biology, Vol 46, Iss 2 (2023)

Abstract Hereditary Hemochromatosis is a disorder characterized by iron deposition in several organs and hyperferritinemia. The most studied variants are linked to the HFE gene. In Brazil, surveys that characterize this population are scarce, with no

Externí odkaz: https://doaj.org/article/1a09ab0882444a3894ef1ed68d9c6e8c

Quantification of peripheral blood CD34+ cells prior to stem cell harvesting by leukapheresis: a single center experience

Autor: Natália Emerim Lemos, Mariela Granero Farias, Francyne Kubaski, Luciana Scotti, Tor Gunnar Hugo Onsten, Letícia de Almeida Brondani, Sandrine Comparsi Wagner, Leo Sekine

Publikováno v: Hematology, Transfusion and Cell Therapy, Vol 40, Iss 3, Pp 213-218 (2018)

Background: Due to laboratory logistic issues, our center has traditionally scheduled peripheral blood stem cell harvests based on timing from the start of mobilization. This has proved to be useful in some cases, but also resulted in many fruitless

Externí odkaz: https://doaj.org/article/d80cce19116c4d9e9b8b76af96544a77

Prevalence of thrombophilia-associated genetic risk factors in blood donors of a regional hospital in southern Brazil

Autor: Nanci Félix Mesquita, Francyne Kubaski, Leo Sekine, Maria Teresa Vieira Sanseverino, Tor Gunnar Hugo Onsten, Sandra Leistner-Segal, Juliana Cristine Fontana, Jéssica Dick-Guareschi

Publikováno v: Hematology, Transfusion and Cell Therapy. 44:379-385

Introduction Thromboembolic events occur due to an imbalance in the hemostasis and some factors associated with this condition can be inherited. In order to evaluate the frequency of genotypes considered to be common hereditary risk factors for throm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc705a9f81456fec9ecd7d00bad3ef7
https://doi.org/10.1016/j.htct.2021.01.010

Quantification of peripheral blood CD34+ cells prior to stem cell harvesting by leukapheresis: a single center experience

Autor: Letícia de Almeida Brondani, Tor Gunnar Hugo Onsten, Francyne Kubaski, Leo Sekine, Natália Emerim Lemos, Luciana Scotti, Mariela Granero Farias, Sandrine Comparsi Wagner

Publikováno v: Hematology, Transfusion and Cell Therapy, Vol 40, Iss 3, Pp 213-218 (2018)
Hematology, Transfusion and Cell Therapy, Volume: 40, Issue: 3, Pages: 213-218, Published: SEP 2018

Background: Due to laboratory logistic issues, our center has traditionally scheduled peripheral blood stem cell harvests based on timing from the start of mobilization. This has proved to be useful in some cases, but also resulted in many fruitless

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2daf90095c737ed2e6d8ac3c61daee
https://doi.org/10.1016/j.htct.2018.01.002

Identification of ACKR1 variants associated with altered Duffy phenotype expression in blood donors from southern Brazil

Autor: Marilu Fiegenbaum, Tor Gunnar Hugo Onsten, Grasiela Agnes, Mirelen Moura de Oliveira Rodrigues, Pâmela Victoria Von Burg, Gabriela Höher, Silvana Almeida, Gabriela Waskow

Publikováno v: Transfusion and Apheresis Science. 59:102768

The atypical chemokine receptor 1 gene (ACKR1) is responsible for the clinically significant Duffy blood group. The main antigens of this system, Fya and Fyb, can be related to a null or weak expression of the DARC protein. In the present work, we ai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7717f3a2b945aca7a01dbdbd645310
https://doi.org/10.1016/j.transci.2020.102768