Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Topologically associating domain"'
Autor:
Manuela Caruso, Diego Mazzatenta, Sofia Asioli, Giuseppe Costanza, Giampaolo Trivellin, Martin Franke, Dayana Abboud, Julien Hanson, Véronique Raverot, Patrick Pétrossians, Albert Beckers, Marco Cappa, Adrian F. Daly
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
X-linked acrogigantism (X-LAG) is a rare form of pituitary gigantism that is associated with growth hormone (GH) and prolactin-secreting pituitary adenomas/pituitary neuroendocrine tumors (PitNETs) that develop in infancy. It is caused by a duplicati
Externí odkaz:
https://doaj.org/article/7947c1800ddc4f16bb1a084904a86f5f
Autor:
Jhen Yuan Yang, Jia-Ming Chang
Publikováno v:
BMC Bioinformatics, Vol 22, Iss S10, Pp 1-15 (2022)
Abstract Background Recent increasing evidence indicates that three-dimensional chromosome structure plays an important role in genomic function. Topologically associating domains (TADs) are self-interacting regions that have been shown to be a chrom
Externí odkaz:
https://doaj.org/article/f8432215efd744449986f19f08a4dc70
Publikováno v:
MedComm, Vol 4, Iss 4, Pp n/a-n/a (2023)
Abstract Linear DNA undergoes a series of compression and folding events, forming various three‐dimensional (3D) structural units in mammalian cells, including chromosomal territory, compartment, topologically associating domain, and chromatin loop
Externí odkaz:
https://doaj.org/article/e189d3feeec54ab6a90d649881199ba8
Akademický článek
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Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 3, Pp 1041-1053 (2022)
The immune checkpoint blockade (ICB) targeting on PD-1/PD-L1 has shown remarkable promise in treating cancers. However, the low response rate and frequently observed severe side effects limit its broad benefits. It is partially due to less understand
Externí odkaz:
https://doaj.org/article/f311de85430840a5b495ec74e63190e9
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4910-4920 (2022)
Cis-regulatory elements of promoters are essential for gene regulation by transcription factors (TFs). However, the regulatory roles of nonpromoter regions, TFs, and epigenetic marks remain poorly understood in plants. In this study, we characterized
Externí odkaz:
https://doaj.org/article/523ed6c792a54bbaa188be47a07b8251
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-26 (2021)
Abstract Background Topologically associating domains (TADs) are important building blocks of three-dimensional genome architectures. The formation of TADs has been shown to depend on cohesin in a loop-extrusion mechanism. Recently, advances in an im
Externí odkaz:
https://doaj.org/article/80d1bcada4eb43aa81375ace6e1ae83c
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Studying the mechanisms of resistance to vanillin in microorganisms, which is derived from lignin and blocks a major pathway of DNA double-strand break repair in yeast, will benefit the design of robust cell factories that produce biofuels and chemic
Externí odkaz:
https://doaj.org/article/f0a92157af4f4f99b5438d34485a7e3f
Autor:
Yongzheng Li, Boxin Xue, Mengling Zhang, Liwei Zhang, Yingping Hou, Yizhi Qin, Haizhen Long, Qian Peter Su, Yao Wang, Xiaodong Guan, Yanyan Jin, Yuan Cao, Guohong Li, Yujie Sun
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-29 (2021)
Abstract Background Metazoan cells only utilize a small subset of the potential DNA replication origins to duplicate the whole genome in each cell cycle. Origin choice is linked to cell growth, differentiation, and replication stress. Although variou
Externí odkaz:
https://doaj.org/article/29d7ff182c9b43a7a9dfebb40a0c3ba2
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-20 (2021)
Abstract Topologically associating domains (TADs) are the organizational units of chromosome structures. TADs can contain TADs, thus forming a hierarchy. TAD hierarchies can be inferred from Hi-C data through coding trees. However, the current method
Externí odkaz:
https://doaj.org/article/9edd677135664810954eb02bf06c961f