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Plasmodium Topoisomerase VIB and Spo11 Constitute Functional Type IIB Topoisomerase in Malaria Parasite: Its Possible Role in Mitochondrial DNA Segregation

Autor: Priyanka Singh, Wahida Tabassum, Nupur Fangaria, Sandeep Dey, Siladitya Padhi, Mrinal K. Bhattacharyya, Kota Arun Kumar, Arijit Roy, Sunanda Bhattacharyya

Publikováno v: Microbiology Spectrum, Vol 11, Iss 3 (2023)

ABSTRACT The human malaria parasite undergoes a noncanonical cell division, namely, endoreduplication, where several rounds of nuclear, mitochondrial, and apicoplast replication occur without cytoplasmic division. Despite its importance in Plasmodium

Externí odkaz: https://doaj.org/article/d42e1672c0364164b309bdd8ba2bc3e1

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Topoisomerase VI participates in an insulator-like function that prevents H3K9me2 spreading

Autor: Louis-Valentin Méteignier, Cécile Lecampion, Florent Velay, Cécile Vriet, Laura Dimnet, Martin Rougée, Christian Breuer, Ludivine Soubigou-Taconnat, Keiko Sugimoto, Fredy Barneche, Christophe Laloi

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (27), ⟨10.1073/pnas.2001290119⟩

The organization of the genome into transcriptionally active and inactive chromatin domains requires well-delineated chromatin boundaries and insulator functions in order to maintain the identity of adjacent genomic loci with antagonistic chromatin m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f421c27f4e489194d1715605a6a05768
https://cnrs.hal.science/hal-03862125/file/2020-01290R_Merged_PDF_B&W.pdf

Radicicol-Mediated Inhibition of Topoisomerase VIB-VIA Activity of the Human Malaria Parasite Plasmodium falciparum

Autor: Sureshkumar Chalapareddy, Swati Chakrabarty, Mrinal Kanti Bhattacharyya, Sunanda Bhattacharyya

Publikováno v: mSphere, Vol 1, Iss 1 (2016)

ABSTRACT Plasmodium falciparum topoisomerase VIB (TopoVIB)-TopoVIA (TopoVIB-VIA) complex can be potentially exploited as a drug target against malaria due to its absence from the human genome. Previous work in our laboratory has suggested that P. fal

Externí odkaz: https://doaj.org/article/1f397b27f64241f1903972e56d9b88ec