Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Topi A, Tervonen"'
Autor:
Denis Belitškin, Pauliina Munne, Shishir M. Pant, Johanna M. Anttila, Ilida Suleymanova, Kati Belitškina, Daniel Kirchhofer, James Janetka, Taivo Käsper, Sami Jalil, Jeroen Pouwels, Topi A. Tervonen, Juha Klefström
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 547-561 (2024)
Hepsin, a type II transmembrane serine protease, is commonly overexpressed in prostate and breast cancer. The hepsin protein is stabilized by the Ras‐MAPK pathway, and, downstream, this protease regulates the degradation of extracellular matrix com
Externí odkaz:
https://doaj.org/article/3e25433eb30948a582897944f0e227ae
Autor:
Jayendrakishore Tanjore Ramanathan, Tomáš Zárybnický, Pauliina Filppu, Hector J Monzo, Outi Monni, Topi A Tervonen, Juha Klefström, Laura Kerosuo, Satu Kuure, Pirjo Laakkonen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract The immunoglobulin (Ig) superfamily members are involved in cell adhesion and migration, complex multistep processes that play critical roles in embryogenesis, wound healing, tissue formation, and many other processes, but their specific fun
Externí odkaz:
https://doaj.org/article/38e001f041124aedace204a28a9ef956
Autor:
Juha Klefström, Emmy W. Verschuren, Panu E. Kovanen, Caj Haglund, Katja Närhi, Johanna I. Englund, Denis Belitškin, Shishir M. Pant, Topi A. Tervonen
Ras proteins play a causal role in human cancer by activating multiple pathways that promote cancer growth and invasion. However, little is known about how Ras induces the first diagnostic features of invasion in solid tumors, including loss of epith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ed27c78bf69ac46bd29a52cb8d6c245
https://doi.org/10.1158/0008-5472.c.6513103.v1
https://doi.org/10.1158/0008-5472.c.6513103.v1
Autor:
Juha Klefström, Emmy W. Verschuren, Panu E. Kovanen, Caj Haglund, Katja Närhi, Johanna I. Englund, Denis Belitškin, Shishir M. Pant, Topi A. Tervonen
Including Supplementary Materials and Methods, Supplementary Figures and Figure Legends 1-5, Supplementary Tables 1-7, and Supplementary References
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73134cbb6038d92209df6fd11a8d7fff
https://doi.org/10.1158/0008-5472.22428706.v1
https://doi.org/10.1158/0008-5472.22428706.v1
Autor:
Topi A. Tervonen, Denis Belitškin, Pauliina Munne, Shishir M. Pant, Ilida Suleymanova, Kati Belitškina, Jeroen Pouwels, Juha Klefström
Publikováno v:
Cancer Research. 82:834-834
Hepsin (encoded by HPN gene) is a type II transmembrane serine protease, which is commonly overexpressed in carcinomas of prostate and breast. Hepsin protein is known to be stabilized by Ras-MAPK pathway signaling, and downstream, this protease regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d595673d3dd605a8bf8eb47f2b3f4756
https://doi.org/10.1158/1538-7445.am2022-834
https://doi.org/10.1158/1538-7445.am2022-834
Autor:
Topi A. Tervonen, Verna Louhivuori, Xiaohong Sun, Marie-Estelle Hokkanen, Claudius F. Kratochwil, Pawel Zebryk, Eero Castrén, Maija L. Castrén
Publikováno v:
Neurobiology of Disease, Vol 33, Iss 2, Pp 250-259 (2009)
The lack of fragile X mental retardation protein (FMRP) causes fragile X syndrome, a common form of inherited mental retardation. Our previous studies revealed alterations in the differentiation of FMRP-deficient neural progenitors. Here, we show abn
Externí odkaz:
https://doaj.org/article/c1e599b948ac48eba42308511382d791
Autor:
Kati Belitškina, Hanna-Ala Hongisto, Jeroen Pouwels, Olga Klezovitch, Outi Monni, Shishir M. Pant, Pirjo Laakkonen, Topi A. Tervonen, Ilida Suleymanova, Valeri Vasioukhin, Johanna Englund, Tiina Raatikainen, Satu Kuure, Shuo Li, Juha Klefström, Denis Belitskin, Qingyu Wu, Pauliina Munne
Publikováno v:
EMBO Reports
Transforming growth factor‐beta (TGFβ) is a multifunctional cytokine with a well‐established role in mammary gland development and both oncogenic and tumor‐suppressive functions. The extracellular matrix (ECM) indirectly regulates TGFβ activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f63cdd7f8b5ddc2c5f2d559f76bb69a
https://doi.org/10.1096/fasebj.2021.35.s1.02255
https://doi.org/10.1096/fasebj.2021.35.s1.02255
Autor:
Topi A, Tervonen, Shishir M, Pant, Denis, Belitškin, Johanna I, Englund, Katja, Närhi, Caj, Haglund, Panu E, Kovanen, Emmy W, Verschuren, Juha, Klefström
Publikováno v:
Cancer research. 81(6)
Ras proteins play a causal role in human cancer by activating multiple pathways that promote cancer growth and invasion. However, little is known about how Ras induces the first diagnostic features of invasion in solid tumors, including loss of epith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fd8e3e40ab74162ad08c8e82f84621ed
https://pubmed.ncbi.nlm.nih.gov/33461973
https://pubmed.ncbi.nlm.nih.gov/33461973
Abstract 3484: Ras recruits oncogenic serine protease hepsin to disrupt mammary epithelial integrity
Autor:
Topi A. Tervonen, Shishir M. Pant, Denis Belitskin, Johanna Englund, Katja Närhi, Emmy Verschuren, Panu Kovanen, Juha Klefström
Publikováno v:
Cancer Research. 79:3484-3484
Type II transmembrane serine protease hepsin is overexpressed and redistributed in clinical breast cancer samples, although the HPN gene is not a frequent target of cancer-specific genetic alterations. Here, we sought to identify cancer relevant upst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bb8118631c7bd2dac00d3929f755d71
https://doi.org/10.1158/1538-7445.am2019-3484
https://doi.org/10.1158/1538-7445.am2019-3484
Autor:
Panu E. Kovanen, Emmy W. Verschuren, Juha Klefström, Johanna Englund, Denis Belitskin, Shishir M. Pant, Topi A. Tervonen
Publikováno v:
Cancer Research. 80:LB-204
Invasive cancer growth occurs when epithelial tumor cells individually or collectively detach from the primary tumor and migrate into the adjacent healthy tissue. This process starts a gradual tumor progression that may lead to life-threatening metas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a11e5b623738b1d3487e5afd87ea5215
https://doi.org/10.1158/1538-7445.am2020-lb-204
https://doi.org/10.1158/1538-7445.am2020-lb-204