Discovery of a Novel Class of Imidazo[1,2-a]Pyridines with Potent PDGFR Activity and Oral Bioavailability.

Autor: Hicken EJ; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Marmsater FP; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Munson MC; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Schlachter ST; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Robinson JE; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Allen S; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Burgess LE; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., DeLisle RK; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Rizzi JP; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Topalov GT; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Zhao Q; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Hicks JM; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Kallan NC; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Tarlton E; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Allen A; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Callejo M; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Cox A; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Rana S; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Klopfenstein N; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Woessner R; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States., Lyssikatos JP; Department of Drug Discovery, Array BioPharma , 3200 Walnut Street, Boulder, Colorado 80301, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2013 Nov 12; Vol. 5 (1), pp. 78-83. Date of Electronic Publication: 2013 Nov 12 (Print Publication: 2014).

Progress in the Chemistry of Organic Natural Products 110 : Cheminformatics in Natural Product Research

Autor: A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Jun'ichi Kobayashi, Yoshinori Asakawa, Ji-Kai Liu

The book summarizes important aspects of cheminformatics that are relevant for natural product research. It highlights cheminformatics tools that help to match natural products with their respective biological targets or off-targets, and discusses th