Raman spectroscopy and one-dimensional convolutional neural network modeling as a real-time monitoring tool for in vitro transaminase-catalyzed synthesis of a pharmaceutically relevant amine precursor.

Autor: Madsen JØ; Department of Chemical and Biochemical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Topalian SON; Department of Chemical and Biochemical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark., Jacobsen MF; Route Design, Process Development, H. Lundbeck A/S, Valby, Denmark., Skovby T; Chemical Production Development, H. Lundbeck A/S, Nykøbing Sjælland, Denmark., Gernaey KV; Department of Chemical and Biochemical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark., Myerson AS; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Woodley J; Department of Chemical and Biochemical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark.

Publikováno v: Biotechnology progress [Biotechnol Prog] 2024 May-Jun; Vol. 40 (3), pp. e3444. Date of Electronic Publication: 2024 Mar 27.