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Akademický článek

Human pancreatic adenocarcinoma contains a side population resistant to gemcitabine

Autor: Van den broeck Anke, Gremeaux Lies, Topal Baki, Vankelecom Hugo

Publikováno v: BMC Cancer, Vol 12, Iss 1, p 354 (2012)

Abstract Background Therapy resistance remains one of the major challenges to improve the prognosis of patients with pancreatic cancer. Chemoresistant cells, which potentially also display cancer stem cell (CSC) characteristics, can be isolated using

Externí odkaz: https://doaj.org/article/8ec3c40006fb444e9d8dda4ce9bd9be4

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Akademický článek

Molecular markers associated with outcome and metastasis in human pancreatic cancer

Autor: Van den Broeck Anke, Vankelecom Hugo, Van Eijsden Rudy, Govaere Olivier, Topal Baki

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 31, Iss 1, p 68 (2012)

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous cancer in which differences in survival rates might be related to a variety in gene expression profiles. Although the molecular biology of PDAC begins to be revealed, gene

Externí odkaz: https://doaj.org/article/75f4927bf50342319837c7973ee43b44

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Akademický článek

Perioperative cancer cell dissemination detected with a real-time RT-PCR assay for EpCAM is not associated with worse prognosis in pancreatic ductal adenocarcinoma

Autor: Houtmeyers François, van Pelt Jos, Roskams Tania, Sergeant Gregory, Aerts Raymond, Topal Baki

Publikováno v: BMC Cancer, Vol 11, Iss 1, p 47 (2011)

Abstract Background Epithelial cell adhesion molecule (EpCAM) has been used as surrogate marker for the quantification of circulating tumour cells (CTC). Our aim was to prospectively study the value of a real-time RT-PCR assay for EpCAM detection in

Externí odkaz: https://doaj.org/article/d7fb5bdfa27944ae98dbe873b65d89da

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Akademický článek

A phase I radiation dose-escalation study to determine the maximal dose of radiotherapy in combination with weekly gemcitabine in patients with locally advanced pancreatic adenocarcinoma

Autor: Aerts Raymond, Topal Baki, Van Steenbergen Werner, Van Cutsem Eric, Haustermans Karin, Budiharto Tom, Ectors Nadine, Bielen Didier, Vanbeckevoort Dirk, Goethals Laurence, Verslype Chris

Publikováno v: Radiation Oncology, Vol 3, Iss 1, p 30 (2008)

Abstract Background The primary objective of this study was to determine the maximum tolerated dose (MTD) of escalating doses of radiotherapy (RT) concomitantly with a fixed dose of gemcitabine (300 mg/m2/week) within the same overall treatment time.

Externí odkaz: https://doaj.org/article/bb4a516df1e144e39481af0643c3e527

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