Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Toops Dana S"'
Autor:
Richard C. Thomas, Matthew J Zaya, Barbachyn Michael R, Wade J. Adams, Betty H. Yagi, Michael A. Wynalda, J P Sams, Larry C. Wienkers, Ford Charles W, J Gregory Slatter, Nancee L. Oien, William Watt, Eric P. Seest, Janice M. Friis, Joel Morris, Judith C. Hamel, Gary E. Zurenko, Lester A. Dolak, Ronda D. Schaadt, Douglas Stapert, Cleek Gary J, Donn G. Wishka, Stuart A. Garmon, Toops Dana S
Publikováno v:
Journal of Medicinal Chemistry. 46:284-302
A new and promising group of antibacterial agents, collectively known as the oxazolidinones and exemplified by linezolid (PNU-100766, marketed as Zyvox), have recently emerged as important new therapeutic agents for the treatment of infections caused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b367ff99342ae88e0043e780292f449
https://doi.org/10.1021/jm020248u
https://doi.org/10.1021/jm020248u
Autor:
Betty H. Yagi, Suzanne E. Glickman, Susan K. Hendges, Ford Charles W, Toops Dana S, Jonda D. Schaadt, Barbachyn Michael R, Douglas Stapert, Kevin C. Grega, Jerry M. Buysse, Judith C. Hamel, James O. Kilburn, Gary E. Zurenko, William F. Demyan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1009-1014
Various electron-withdrawing groups were incorporated into the meta position of tropone-substituted 3-phenyl-2-oxazolidinones and their influence on antibacterial activity examined. Consideration of in vitro and in vivo test results indicated that on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0dd928cb5886649f84d91fbdc7e4276
https://doi.org/10.1016/0960-894x(96)00155-2
https://doi.org/10.1016/0960-894x(96)00155-2
Autor:
Sally P. Klemens, Toops Dana S, James O. Kilburn, Susan K. Hendges, Ford Charles W, S. E. Glickman, Gary E. Zurenko, Kevin C. Grega, Steven J. Brickner, Michael H. Cynamon, Hutchinson Douglas K, Barbachyn Michael R
Publikováno v:
Journal of Medicinal Chemistry. 39:680-685
During the course of our investigations in the oxazolidinone antibacterial agent area, we have identified a subclass with especially potent in vitro activity against mycobacteria. The salient structural feature of these oxazolidinone analogues, 6 (U-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd36c5010853b90f6315fcfa170f5c2
https://doi.org/10.1021/jm950956y
https://doi.org/10.1021/jm950956y
Autor:
Susan K. Hendges, Toops Dana S, Hutchinson Douglas K, Manninen Peter Rudolph, Barbachyn Michael R, Gary E. Zurenko, Stuart A. Garmon, Steven J. Brickner, Ford Charles W, Kevin C. Grega, Debra A. Ulanowicz
Publikováno v:
Journal of Medicinal Chemistry. 39:673-679
Bacterial resistance development has become a very serious clinical problem for many classes of antibiotics. The 3-aryl-2-oxazolidinones are a relatively new class of synthetic antibacterial agents, having a new mechanism of action which involves ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aabb6b3bba82a4a3a9cb3b1862302a7
https://doi.org/10.1021/jm9509556
https://doi.org/10.1021/jm9509556
Autor:
Toops Dana S, Barbachyn Michael R
Publikováno v:
The Journal of Organic Chemistry. 58:6505-6508
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a95a4479f19d496e323a558f8350e72
https://doi.org/10.1021/jo00075a063
https://doi.org/10.1021/jo00075a063
Autor:
Raymond J. Reid, Gary E. Zurenko, Ronda D. Schaadt, Barbachyn Michael R, John W. Allison, Toops Dana S, Hutchinson Douglas K, Betty H. Yagi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:671-676
Incorporation of a bicyclo[1.1.1]pent-1-yl group at the N-1 position of quinolone antibacterial agents affords compounds with potent activity. One of these analogs, U-87947E, exhibits enhanced activity relative to that of ciprofloxacin against gram-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d473c3ab37e1a7576f9f4b87c210bbc6
https://doi.org/10.1016/s0960-894x(01)81251-8
https://doi.org/10.1016/s0960-894x(01)81251-8
Autor:
Ronda D. Schaadt, Betty H. Yagi, R. J. Reid, J. W. Allison, Gary E. Zurenko, Toops Dana S, Barbachyn Michael R, Hutchinson Douglas K
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96cb677bcc0b692dfb7e64777b527ce6
https://doi.org/10.1002/chin.199508193
https://doi.org/10.1002/chin.199508193
Autor:
Betty H. Yagi, Kevin C. Grega, Ronda D. Schaadt, W. F. Demyan, Toops Dana S, Gary E. Zurenko, Steven J. Brickner, J. O. Kilburn, Barbachyn Michael R, Debra A. Ulanowicz, Ford Charles W, S. E. Glickman, Judith C. Hamel, J. M. Buysse, Douglas Stapert
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15d27743efd29b12fa0ee68e52d3e0a8
https://doi.org/10.1002/chin.199636129
https://doi.org/10.1002/chin.199636129
Autor:
Susan K. Hendges, Kevin C. Grega, Hutchinson Douglas K, Gary E. Zurenko, Manninen Peter Rudolph, Toops Dana S, Stuart A. Garmon, Ford Charles W, Steven J. Brickner, Debra A. Ulanowicz, Barbachyn Michael R
Publikováno v:
ChemInform. 27
Bacterial resistance development has become a very serious clinical problem for many classes of antibiotics. The 3-aryl-2-oxazolidinones are a relatively new class of synthetic antibacterial agents, having a new mechanism of action which involves ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41e79c504ba9874c79e0b97f0dab22ce
https://doi.org/10.1002/chin.199621139
https://doi.org/10.1002/chin.199621139
Autor:
Michael H. Cynamon, Steven J. Brickner, Susan K. Hendges, Sally P. Klemens, Hutchinson Douglas K, Gary E. Zurenko, James O. Kilburn, S. E. Glickman, Barbachyn Michael R, Kevin C. Grega, Ford Charles W, Toops Dana S
Publikováno v:
ChemInform. 27
During the course of our investigations in the oxazolidinone antibacterial agent area, we have identified a subclass with especially potent in vitro activity against mycobacteria. The salient structural feature of these oxazolidinone analogues, 6 (U-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d40bb5e9d59894c74cf379263d5bc877
https://doi.org/10.1002/chin.199621140
https://doi.org/10.1002/chin.199621140