Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Toon A B van Veen"'
Autor:
Siddarth Soni, Antonia J A Raaijmakers, Linsey M Raaijmakers, J Mirjam A Damen, Leonie van Stuijvenberg, Marc A Vos, Albert J R Heck, Toon A B van Veen, Arjen Scholten
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0152231 (2016)
AIMS:Synchronous beating of the heart is dependent on the efficient functioning of the cardiac intercalated disk (ID). The ID is composed of a complex protein network enabling electrical continuity and chemical communication between individual cardio
Externí odkaz:
https://doaj.org/article/0b7a0274d6d84bf1b6e6b9b5692925bf
Autor:
Arnold Vreeker, Leonie van Stuijvenberg, Thomas J Hund, Peter J Mohler, Peter G J Nikkels, Toon A B van Veen
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94722 (2014)
In cardiac muscle, the intercalated disk (ID) at the longitudinal cell-edges of cardiomyocytes provides as a macromolecular infrastructure that integrates mechanical and electrical coupling within the heart. Pathophysiological disturbance in composit
Externí odkaz:
https://doaj.org/article/641b9bcee89c42a5833b01df0cb7a22d
Autor:
Mèra Stein, Toon A B van Veen, Richard N W Hauer, Jacques M T de Bakker, Harold V M van Rijen
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20310 (2011)
INTRODUCTION: Computer simulations suggest that intercellular coupling is more robust than membrane excitability with regard to changes in and safety of conduction. Clinical studies indicate that SCN5A (excitability) and/or Connexin43 (Cx43, intercel
Externí odkaz:
https://doaj.org/article/c64178cf2e7b4558a175ca8ba7c1d025
Autor:
Willem B. van Ham, Esmeralda E. M. Meijboom, Merel L. Ligtermoet, Peter G. J. Nikkels, Toon A. B. van Veen
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 10, Iss 8, p 354 (2023)
The development of the normal human heart, ranging from gestational age to the mature adult heart, relies on a very delicate and timely orchestrated order of processes. One of the most striking alterations in time is the gradual extinction of the abi
Externí odkaz:
https://doaj.org/article/54e18138646b4512814ae4be390912db
Autor:
Stephanie M. van der Voorn, Mimount Bourfiss, Steven A. Muller, Tolga Çimen, Ardan M. Saguner, Firat Duru, Anneline S. J. M. te Riele, Carol Ann Remme, Toon A. B. van Veen
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 813 (2023)
Arrhythmogenic cardiomyopathy (ACM) is a progressive inheritable disease which is characterized by a gradual fibro-(fatty) replacement of the myocardium. Visualization of diffuse and patchy fibrosis patterns is challenging using clinically applied ca
Externí odkaz:
https://doaj.org/article/2101393d438542ce8aba94d19afeb921
Autor:
Stephanie M. van der Voorn, Mimount Bourfiss, Anneline S. J. M. te Riele, Karim Taha, Marc A. Vos, Remco de Brouwer, Tom E. Verstraelen, Rudolf A. de Boer, Carol Ann Remme, Toon A. B. van Veen
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2022)
Background: Pathogenic variants in phospholamban (PLN, like p. Arg14del), are found in patients diagnosed with arrhythmogenic (ACM) and dilated cardiomyopathy (DCM). Fibrosis formation in the heart is one of the hallmarks in PLN p.Arg14del carriers.
Externí odkaz:
https://doaj.org/article/6192dc2f457e4711a5d653f5b6215f1f
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Background: Patients with arrhythmogenic cardiomyopathy may suffer from lethal ventricular arrhythmias. Arrhythmogenic cardiomyopathy is predominantly triggered by mutations in plakophilin-2, a key component of cell-to-cell adhesion and calcium cycli
Externí odkaz:
https://doaj.org/article/bcb80fd8383e42678afc85f90beae7ce
Publikováno v:
Physiological Reviews. 103:2271-2319
The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via mechanical and electrical junctions. Although described in some detail by light microscopy in the 19th century, it was in 1966 that electron microscopy imag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d328f75521de69897f84c7b3d40eb7c
https://doi.org/10.1152/physrev.00021.2022
https://doi.org/10.1152/physrev.00021.2022
Autor:
Jiong-Wei Wang, Magda S. C. Fontes, Xiaoyuan Wang, Suet Yen Chong, Elise L. Kessler, Ya-Nan Zhang, Judith J. de Haan, Fatih Arslan, Saskia C. A. de Jager, Leo Timmers, Toon A. B. van Veen, Carolyn S. P. Lam, Dominique P. V. de Kleijn
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract An involement of Toll-like receptor 2 (TLR2) has been established in cardiac dysfunction after acute myocardial infarction; however, its role in chronic pressure overload is unclear. We sought to evaluate the role of TLR2 in cardiac hypertro
Externí odkaz:
https://doaj.org/article/d91281989b32469aa064567a69b66e0f
Autor:
Willem B. van Ham, Carlijn M. Cornelissen, Elizaveta Polyakova, Stephanie M. van der Voorn, Merel L. Ligtermoet, Jantine Monshouwer-Kloots, Marc A. Vos, Alexandre Bossu, Eva van Rooij, Marcel A. G. van der Heyden, Toon A. B. van Veen
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5373
Chronic kidney disease (CKD) is represented by a diminished filtration capacity of the kidneys. End-stage renal disease patients need dialysis treatment to remove waste and toxins from the circulation. However, endogenously produced uremic toxins (UT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e349f9186fb3bbab294b7324b1b359